USP25 and RPS10-NUDT3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		USP25	RPS10-NUDT3
Description		ubiquitin specific peptidase 25	RPS10-NUDT3 readthrough
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin-like Protein Peptidase Activity Ubiquitin Protein Ligase Binding SUMO Binding Ubiquitin Binding ATPase Binding Deubiquitinase Activity
	Biological Process	Proteolysis Protein Deubiquitination Regulation Of Protein Stability Cellular Response To Oxidative Stress Protein Modification Process Interleukin-17A-mediated Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Response To Oxidative Stress Negative Regulation Of Interleukin-17-mediated Signaling Pathway Negative Regulation Of ERAD Pathway
Pathways		Ub-specific processing proteases
Drugs
Diseases
GWAS		Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Serum alkaline phosphatase levels ( 33547301) Severe autoimmune type 2 diabetes ( 34737425) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	A body shape index ( 34021172) Creatinine levels ( 29403010) Fasting insulin ( 34059833) Glomerular filtration rate ( 29403010) Height ( 31562340) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 32888494) Refractive error ( 32231278) Triglyceride levels ( 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		37 interacting genes: ACTA1 ARMC8 CDC73 CNTN1 EIF4A3 FBXL17 FLNC GAPDH GDI1 MAGEB4 MAVS MID2 MT2A NAP1L3 PAX6 PUS10 RAD23A RAD23B RPS10-NUDT3 RSL1D1 SENP1 SKIL SNRNP70 SUMO1 SUMO2 SUMO3 SYK TMEM43 TNKS TNKS2 TUBB UBC UBE2I VPS45 YARS1 ZNF426 ZNF841	1 interacting genes: USP25
Entrez ID		29761	100529239
HPRD ID		05296
Ensembl ID		ENSG00000155313	ENSG00000270800
Uniprot IDs		Q9UHP3	A0A1W2PQS6
PDB IDs		2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM
Enriched GO Terms of Interacting Partners?		Presynaptic Cytosol Protein Tag Activity Protein Sumoylation Postsynaptic Cytosol Nucleus Post-translational Protein Modification Protein Modification By Small Protein Conjugation PML Body Protein Poly-ADP-ribosylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Ubiquitin-like Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Small Protein Activating Enzyme Binding Positive Regulation Of Telomere Capping Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Glutamatergic Synapse Modification-dependent Protein Catabolic Process Protein Metabolic Process Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity Regulation Of Telomere Capping Protein Localization To Organelle Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Cytosol Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Proteasome Binding Negative Regulation Of DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-specific Protease Binding Cellular Response To Cadmium Ion SUMO Transferase Activity Transcription Factor Binding Nuclear Pore NAD+-protein Mono-ADP-ribosyltransferase Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Pericentriolar Material Positive Regulation Of Telomere Maintenance Via Telomerase Response To Cytokine	Negative Regulation Of Interleukin-17-mediated Signaling Pathway Ubiquitin-like Protein Peptidase Activity Interleukin-17A-mediated Signaling Pathway Negative Regulation Of ERAD Pathway Negative Regulation Of Response To Oxidative Stress SUMO Binding Protein K63-linked Deubiquitination Regulation Of ERAD Pathway Deubiquitinase Activity Protein K48-linked Deubiquitination Regulation Of Response To Oxidative Stress Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Proteasomal Protein Catabolic Process ATPase Binding Regulation Of Response To Endoplasmic Reticulum Stress Cysteine-type Deubiquitinase Activity Protein Deubiquitination Negative Regulation Of Cytokine-mediated Signaling Pathway Protein K48-linked Ubiquitination Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Ubiquitin Binding Negative Regulation Of Response To Cytokine Stimulus Protein Modification By Small Protein Removal Negative Regulation Of Protein Catabolic Process Cysteine-type Peptidase Activity Negative Regulation Of Proteolysis Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Oxidative Stress Cellular Response To Chemical Stress Protein Polyubiquitination Ubiquitin Protein Ligase Binding
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