USP25 and CNTN1

Number of citations of the paper that reports this interaction (PubMedID 35171955)
70

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		USP25	CNTN1
Description		ubiquitin specific peptidase 25	contactin 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol	Plasma Membrane Membrane Axon Presynaptic Membrane Synapse Postsynaptic Membrane Extracellular Exosome Side Of Membrane Glutamatergic Synapse
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin-like Protein Peptidase Activity Ubiquitin Protein Ligase Binding SUMO Binding Ubiquitin Binding ATPase Binding Deubiquitinase Activity	Protein Binding Carbohydrate Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Proteolysis Protein Deubiquitination Regulation Of Protein Stability Cellular Response To Oxidative Stress Protein Modification Process Interleukin-17A-mediated Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Response To Oxidative Stress Negative Regulation Of Interleukin-17-mediated Signaling Pathway Negative Regulation Of ERAD Pathway	Cell Adhesion Notch Signaling Pathway Axon Guidance Brain Development Locomotory Behavior Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Cerebellum Development Neuron Projection Development Central Nervous System Myelin Formation Myelination Cell-cell Adhesion
Pathways		Ub-specific processing proteases	Activated NOTCH1 Transmits Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus L1CAM interactions Neurofascin interactions
Drugs
Diseases
GWAS		Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Serum alkaline phosphatase levels ( 33547301) Severe autoimmune type 2 diabetes ( 34737425) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Blood protein levels ( 30072576) Body mass index ( 26426971) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Metabolite levels (X-11787) ( 23934736) Motion sickness ( 25628336) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pneumoconiosis in silica exposure ( 24986923) Protein quantitative trait loci ( 18464913)
Interacting Genes		37 interacting genes: ACTA1 ARMC8 CDC73 CNTN1 EIF4A3 FBXL17 FLNC GAPDH GDI1 MAGEB4 MAVS MID2 MT2A NAP1L3 PAX6 PUS10 RAD23A RAD23B RPS10-NUDT3 RSL1D1 SENP1 SKIL SNRNP70 SUMO1 SUMO2 SUMO3 SYK TMEM43 TNKS TNKS2 TUBB UBC UBE2I VPS45 YARS1 ZNF426 ZNF841	17 interacting genes: CNTN2 FYN GPR37 L1CAM MAPK6 MAVS NOTCH1 NOTCH2 PPP1CA PRNP PTPRB SCN3A SCNN1B TMEM132D TNC TNR USP25
Entrez ID		29761	1272
HPRD ID		05296	07189
Ensembl ID		ENSG00000155313	ENSG00000018236
Uniprot IDs		Q9UHP3	Q12860
PDB IDs		2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM	2EE2 3S97
Enriched GO Terms of Interacting Partners?		Presynaptic Cytosol Protein Tag Activity Protein Sumoylation Postsynaptic Cytosol Nucleus Post-translational Protein Modification Protein Modification By Small Protein Conjugation PML Body Protein Poly-ADP-ribosylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Ubiquitin-like Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Small Protein Activating Enzyme Binding Positive Regulation Of Telomere Capping Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Glutamatergic Synapse Modification-dependent Protein Catabolic Process Protein Metabolic Process Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity Regulation Of Telomere Capping Protein Localization To Organelle Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Cytosol Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Proteasome Binding Negative Regulation Of DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-specific Protease Binding Cellular Response To Cadmium Ion SUMO Transferase Activity Transcription Factor Binding Nuclear Pore NAD+-protein Mono-ADP-ribosyltransferase Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Pericentriolar Material Positive Regulation Of Telomere Maintenance Via Telomerase Response To Cytokine	Neuron Projection Development Neuron Projection Guidance Plasma Membrane Bounded Cell Projection Organization Axon Guidance Cell Projection Organization Cell Surface Cellular Response To Tumor Cell Type 5 Metabotropic Glutamate Receptor Binding Tenascin Complex Negative Regulation Of Dendritic Spine Maintenance Positive Regulation Of Cell Communication Positive Regulation Of Signaling Atrioventricular Node Development Developmental Growth Receptor Complex Dendritic Spine Maintenance Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Dendritic Spine Maintenance Regulation Of Calcium Ion Import Across Plasma Membrane Left/right Axis Specification Synapse Organization Learning Or Memory Schaffer Collateral - CA1 Synapse Pulmonary Valve Morphogenesis Nervous System Process Positive Regulation Of Ras Protein Signal Transduction Cell Migration Glutamatergic Synapse Morphogenesis Of An Epithelial Sheet Regulation Of Cellular Component Organization Cognition Response To Stress Prostate Gland Epithelium Morphogenesis Negative Regulation Of Cell Adhesion Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Morphogenesis Of An Epithelium Renal Tubule Development Positive Regulation Of Protein Targeting To Membrane Cellular Response To Hormone Stimulus Developmental Growth Involved In Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Motility Regulation Of Axonogenesis Regulation Of Cell Projection Organization Response To Oxidative Stress Regulation Of Astrocyte Differentiation Regulation Of Protein Targeting To Membrane Dendritic Spine Organization
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