SGK1 and PDK1

Number of citations of the paper that reports this interaction (PMID 17314099)
13

Data Source:
BioGRID (enzymatic study)

		SGK1	PDK1
Gene Name		serum/glucocorticoid regulated kinase 1	pyruvate dehydrogenase kinase, isozyme 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Cytosol Plasma Membrane	Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity	Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process Response To Stress Cellular Response To DNA Damage Stimulus Long-term Memory Regulation Of Blood Pressure Regulation Of Cell Migration Positive Regulation Of Transporter Activity Ion Transmembrane Transport Regulation Of Cell Proliferation Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Transmembrane Transport Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption	Glucose Metabolic Process Pyruvate Metabolic Process Protein Phosphorylation Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Glucose Metabolic Process Cellular Metabolic Process Small Molecule Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway
Pathways		Ion channel transport Stimuli-sensing channels	Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs
Diseases
GWAS		Body mass index (interaction) ( 23192594) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)	Erectile dysfunction ( 22704111)
Protein-Protein Interactions		31 interactors: BRAF CAMKK1 CARHSP1 CDKN1B CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAPK7 MAPT MLLT3 NDRG1 NEDD4 NEDD4L NEK6 PDK1 PDK2 PDPK1 PIK3CA PPP2CA RABAC1 RICTOR SLC1A3 SLC9A3R2 TMEM184C	9 interactors: DLAT KAT2B PDHA1 PDK2 RPS6KB1 SGK1 USP4 XRCC6 YWHAQ
Entrez ID		6446	5163
HPRD ID		04264	03954
Ensembl ID		ENSG00000118515
Uniprot IDs		E9PR89 O00141	B7Z937 E9PD65 Q15118
PDB IDs		2R5T 3HDM 3HDN	2Q8F 2Q8G 2Q8H
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Phosphatidylinositol-mediated Signaling Response To Growth Factor Fc-epsilon Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Signaling Negative Regulation Of Signal Transduction Signaling Regulation Of Protein Metabolic Process Response To Stress Apoptotic Process Cell Communication Programmed Cell Death Innate Immune Response Cell Death Death Regulation Of Signal Transduction Regulation Of Immune Response Response To Inorganic Substance Response To Metal Ion Response To Organic Substance Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Phosphorylation Cellular Response To Stress Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Immune Response Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Response To Peptide Hormone Immune System Process	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Glucose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Metabolic Process Hexose Metabolic Process Cellular Response To Insulin Stimulus Monosaccharide Metabolic Process Tricarboxylic Acid Cycle Regulation Of Gluconeogenesis Long-term Memory Citrate Metabolic Process Response To Insulin Regulation Of Lipid Metabolic Process Cellular Response To Peptide Hormone Stimulus Tricarboxylic Acid Metabolic Process Cellular Response To Peptide Aerobic Respiration Apoptotic Process Programmed Cell Death Cell Death Death Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Glucose Metabolic Process Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation Positive Regulation Of Skeletal Muscle Tissue Growth Memory Monocarboxylic Acid Metabolic Process Cellular Response To Hormone Stimulus Cellular Hyperosmotic Salinity Response Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation N-terminal Peptidyl-lysine Acetylation Insulin Receptor Signaling Pathway Regulation Of Carbohydrate Metabolic Process Regulation Of Phosphorus Metabolic Process Renal Sodium Ion Absorption Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Respiration Renal Sodium Ion Transport Skeletal Muscle Atrophy Regulation Of Cellular Process Cellular Response To X-ray Striated Muscle Atrophy Response To Leucine Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		apical autophosphorylate autophosphorylation c4 cer ceramide cf cftr chloride coincidently conductance corrects cystic defect deltaf508 explants folding hypersecretion inactivates mutual pdk1 permit phosphorylates physiologically ser suppresses thr traffic trafficking	additive arginine claims conceptus conceptuses cooperative cooperatively embryo extra fetus greatest histotroph implantation limitation mammals mtorc1 multifunctional otr1 ovine peri phosphoprotein pkb rgd rspp1 spp1 synergistic trophectoderm tsc2 uterine
Tagcloud (Difference) ?		apical autophosphorylate autophosphorylation c4 cer ceramide cf cftr chloride coincidently conductance corrects cystic defect deltaf508 explants folding hypersecretion inactivates mutual permit phosphorylates physiologically ser suppresses thr traffic trafficking	additive arginine claims conceptus conceptuses cooperative cooperatively embryo extra fetus greatest histotroph implantation limitation mammals mtorc1 multifunctional otr1 ovine peri phosphoprotein pkb rgd rspp1 spp1 synergistic trophectoderm tsc2 uterine
Tagcloud (Intersection) ?		pdk1