SGK1 and CAMKK1

Number of citations of the paper that reports this interaction (PMID 12628440)
3

Data Source:
HPRD (in vivo)

		SGK1	CAMKK1
Gene Name		serum/glucocorticoid regulated kinase 1	calcium/calmodulin-dependent protein kinase kinase 1, alpha
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Cytosol Plasma Membrane	Nucleus Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity	Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process Response To Stress Cellular Response To DNA Damage Stimulus Long-term Memory Regulation Of Blood Pressure Regulation Of Cell Migration Positive Regulation Of Transporter Activity Ion Transmembrane Transport Regulation Of Cell Proliferation Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Transmembrane Transport Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption	Protein Phosphorylation Synaptic Transmission
Pathways		Ion channel transport Stimuli-sensing channels	CREB phosphorylation through the activation of CaMKK Activation of NMDA receptor upon glutamate binding and postsynaptic events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses Post NMDA receptor activation events
Drugs
Diseases
GWAS		Body mass index (interaction) ( 23192594) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)	Smoking behavior ( 19247474)
Protein-Protein Interactions		31 interactors: BRAF CAMKK1 CARHSP1 CDKN1B CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAPK7 MAPT MLLT3 NDRG1 NEDD4 NEDD4L NEK6 PDK1 PDK2 PDPK1 PIK3CA PPP2CA RABAC1 RICTOR SLC1A3 SLC9A3R2 TMEM184C	8 interactors: AKT1 APP CALM1 CAMK1 CAMK1D CAMK4 SGK1 YWHAG
Entrez ID		6446	84254
HPRD ID		04264	13000
Ensembl ID		ENSG00000118515	ENSG00000004660
Uniprot IDs		E9PR89 O00141	F8W9H1 J3KPJ3 Q8N5S9
PDB IDs		2R5T 3HDM 3HDN
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Phosphatidylinositol-mediated Signaling Response To Growth Factor Fc-epsilon Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Signaling Negative Regulation Of Signal Transduction Signaling Regulation Of Protein Metabolic Process Response To Stress Apoptotic Process Cell Communication Programmed Cell Death Innate Immune Response Cell Death Death Regulation Of Signal Transduction Regulation Of Immune Response Response To Inorganic Substance Response To Metal Ion Response To Organic Substance Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Phosphorylation Cellular Response To Stress Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Immune Response Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Response To Peptide Hormone Immune System Process	Positive Regulation Of Transport Regulation Of Intracellular Transport Phosphorylation Regulation Of Neuron Differentiation Positive Regulation Of Intracellular Transport Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of Neurogenesis Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Cell Differentiation Phosphate-containing Compound Metabolic Process Regulation Of Cell Development Regulation Of Cellular Localization Positive Regulation Of Protein Export From Nucleus Establishment Of Localization In Cell Regulation Of Protein Phosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Nervous System Development Positive Regulation Of Monooxygenase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Phosphorylation Cellular Localization Cellular Response To Fibroblast Growth Factor Stimulus Defense Response Platelet Activation Response To Fibroblast Growth Factor System Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Nitric Oxide Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization Cell Activation Reactive Nitrogen Species Metabolic Process Regulation Of Protein Export From Nucleus Neurotrophin Signaling Pathway Regulation Of Phosphorus Metabolic Process Intracellular Transport Positive Regulation Of Catalytic Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Generation Of Neurons Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Oxidoreductase Activity Nucleocytoplasmic Transport Learning Or Memory Nuclear Transport Regulation Of Protein Localization
Tagcloud ?		apical autophosphorylate autophosphorylation c4 cer ceramide cf cftr chloride coincidently conductance corrects cystic defect deltaf508 explants folding hypersecretion inactivates mutual pdk1 permit phosphorylates physiologically ser suppresses thr traffic trafficking	akt apoptosis br calcium calmodulin er estrogen exact irrespective knockdown largely mb mcf mda moderately neural oncotarget pcp4 pep19 phospho potentially regulates serve sk slightly still thr308 unknown
Tagcloud (Difference) ?		apical autophosphorylate autophosphorylation c4 cer ceramide cf cftr chloride coincidently conductance corrects cystic defect deltaf508 explants folding hypersecretion inactivates mutual pdk1 permit phosphorylates physiologically ser suppresses thr traffic trafficking	akt apoptosis br calcium calmodulin er estrogen exact irrespective knockdown largely mb mcf mda moderately neural oncotarget pcp4 pep19 phospho potentially regulates serve sk slightly still thr308 unknown
Tagcloud (Intersection) ?