SGK1 and ASPG

Number of citations of the paper that reports this interaction (PubMedID 21063096)
0

Data Source:
BioGRID (pull down)

		SGK1	ASPG
Description		serum/glucocorticoid regulated kinase 1	asparaginase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Nuclear Speck	Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Kinase Activity Transferase Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity Protein Serine Kinase Activity	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Asparaginase Activity Phosphatidylcholine Lysophospholipase Activity Protein Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Hydrolase Activity
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process DNA Damage Response Long-term Memory Regulation Of Blood Pressure Regulation Of Cell Migration Positive Regulation Of Transporter Activity Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Neuron Projection Morphogenesis Regulation Of Catalytic Activity Regulation Of DNA-binding Transcription Factor Activity Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Aldosterone	Amino Acid Metabolic Process Lipid Metabolic Process Aspartate Family Amino Acid Metabolic Process Lipid Catabolic Process
Pathways		PIP3 activates AKT signaling Stimuli-sensing channels Regulation of TP53 Degradation Transcriptional Regulation by MECP2 NGF-stimulated transcription	Aspartate and asparagine metabolism
Drugs		Flavin mononucleotide [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	Procaine
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Body mass index (smoking years interaction) ( 23192594) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Pelvic organ prolapse ( 26545240) Pelvic organ prolapse (moderate/severe) ( 26545240) Refractive error ( 32231278) Schizophrenia (inflammation and infection response interaction) ( 25781172) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)	Body mass index ( 26426971) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma free asparagine levels ( 30659259) Refractive error ( 32231278) Schizophrenia ( 29483656) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748)
Interacting Genes		38 interacting genes: ASPG BRAF CAMKK1 CARHSP1 CDKN1B CDKN2A CETN3 CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAL2 MAPK7 MAPKAP1 MLLT3 NDRG1 NDRG4 NEDD4 NEDD4L NEK6 NHERF2 PDK1 PDK2 PDPK1 PIK3CA PIN1 PPP2CA RABAC1 RICTOR SLC1A3 TMEM184C UBC	12 interacting genes: CEACAM6 CIMIP1 DMRT3 GSDMD MYOZ3 RTP5 SGK1 SHC3 TEKT3 TMEM115 USP2 VPS25
Entrez ID		6446	374569
HPRD ID		04264	19180
Ensembl ID		ENSG00000118515	ENSG00000166183
Uniprot IDs		B7Z325 E9PR89 O00141	G3V1Y8 Q86U10
PDB IDs		2R5T 3HDM 3HDN 7PUE
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Cytosol Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Regulation Of Growth Cellular Response To Stress Positive Regulation Of Signal Transduction Kinase Activity Protein Serine Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Protein Kinase Activity Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Oxygen-containing Compound Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine/threonine Kinase Activity Tau Protein Binding Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity TORC2 Signaling Apoptotic Signaling Pathway Response To Metal Ion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Phosphothreonine Residue Binding Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Cell Growth Regulation Of Glycogen (starch) Synthase Activity ATP Binding Regulation Of Phosphorus Metabolic Process Regulation Of Amide Metabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Wnt Signaling Pathway Cytoplasm Cellular Response To Peptide Hormone Stimulus
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