SGK1 and MAPKAP1

Number of citations of the paper that reports this interaction (PubMedID 28264193)
80

Data Source:
BioGRID (pull down)

		SGK1	MAPKAP1
Description		serum/glucocorticoid regulated kinase 1	MAPK associated protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Nuclear Speck	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cilium Membrane Early Endosome Membrane Late Endosome Membrane TORC2 Complex Perinuclear Region Of Cytoplasm Serine/threonine Protein Kinase Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Kinase Activity Transferase Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity Protein Serine Kinase Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Small GTPase Binding Phosphatidylinositol-3,4-bisphosphate Binding Molecular Adaptor Activity Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding Enzyme-substrate Adaptor Activity
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process DNA Damage Response Long-term Memory Regulation Of Blood Pressure Regulation Of Cell Migration Positive Regulation Of Transporter Activity Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Neuron Projection Morphogenesis Regulation Of Catalytic Activity Regulation Of DNA-binding Transcription Factor Activity Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Aldosterone	Ubiquitin-dependent Protein Catabolic Process Cytoskeleton Organization Insulin Receptor Signaling Pathway Substantia Nigra Development Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels Cellular Response To Insulin Stimulus TORC2 Signaling Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Insulin Receptor Signaling Pathway Protein Stabilization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cellular Response To Oxidative Stress
Pathways		PIP3 activates AKT signaling Stimuli-sensing channels Regulation of TP53 Degradation Transcriptional Regulation by MECP2 NGF-stimulated transcription	PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Flavin mononucleotide [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Body mass index (smoking years interaction) ( 23192594) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Pelvic organ prolapse ( 26545240) Pelvic organ prolapse (moderate/severe) ( 26545240) Refractive error ( 32231278) Schizophrenia (inflammation and infection response interaction) ( 25781172) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)	Body mass index ( 28892062) Diverticular disease ( 30177863) Fish- and plant-related diet ( 32066663) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (calcium channel blockers) ( 31015401) Raw vegetable consumption ( 32066663) Resting heart rate ( 27798624) Sleep duration ( 30531941) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		38 interacting genes: ASPG BRAF CAMKK1 CARHSP1 CDKN1B CDKN2A CETN3 CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAL2 MAPK7 MAPKAP1 MLLT3 NDRG1 NDRG4 NEDD4 NEDD4L NEK6 NHERF2 PDK1 PDK2 PDPK1 PIK3CA PIN1 PPP2CA RABAC1 RICTOR SLC1A3 TMEM184C UBC	12 interacting genes: ABCB1 AKT1 CDC42EP1 ECI1 MAPK8 MLST8 MTOR NRAS PRKCA SGK1 UBC YWHAG
Entrez ID		6446	79109
HPRD ID		04264	17464
Ensembl ID		ENSG00000118515	ENSG00000119487
Uniprot IDs		B7Z325 E9PR89 O00141	Q9BPZ7
PDB IDs		2R5T 3HDM 3HDN 7PUE	3VOQ 5ZCS 6ZWM 6ZWO 7LC1 7LC2 7PE7 7PE8 7PE9 7TZO 7VV8 7VV9 7VVB 7VVG
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Cytosol Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Regulation Of Growth Cellular Response To Stress Positive Regulation Of Signal Transduction Kinase Activity Protein Serine Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Protein Kinase Activity Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Oxygen-containing Compound Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine/threonine Kinase Activity Tau Protein Binding Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity TORC2 Signaling Apoptotic Signaling Pathway Response To Metal Ion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Phosphothreonine Residue Binding Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Cell Growth Regulation Of Glycogen (starch) Synthase Activity ATP Binding Regulation Of Phosphorus Metabolic Process Regulation Of Amide Metabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Wnt Signaling Pathway Cytoplasm Cellular Response To Peptide Hormone Stimulus	Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation TORC1 Signaling TOR Signaling Intracellular Signal Transduction Positive Regulation Of TOR Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Nutrient Levels Positive Regulation Of Cellular Component Biogenesis Intracellular Signaling Cassette Cellular Response To Nutrient Levels Response To Peptide Hormone Response To Hormone Cellular Response To Hormone Stimulus Protein Serine Kinase Activity Regulation Of TOR Signaling Positive Regulation Of Pentose-phosphate Shunt Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Serine/threonine Kinase Activity Cellular Response To Osmotic Stress Positive Regulation Of Actin Filament Polymerization Regulation Of Biological Quality Negative Regulation Of Translation Cellular Response To Starvation TORC1 Complex Regulation Of Pentose-phosphate Shunt SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Oxygen-containing Compound Negative Regulation Of TORC1 Signaling Response To Ketone Positive Regulation Of TORC1 Signaling Response To Starvation Regulation Of NADP Metabolic Process Protein Kinase Activity Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Response To Osmotic Stress TORC2 Complex Response To Alcohol Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Polymerization Cellular Response To Chemical Stress Cellular Response To Stress Anoikis Negative Regulation Of TOR Signaling Post-transcriptional Regulation Of Gene Expression Mitochondrion Positive Regulation Of Endothelial Cell Proliferation Regulation Of TORC2 Signaling
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