SGK1 and MAPK7

Number of citations of the paper that reports this interaction (PMID 11254654)
19

Data Source:
BioGRID (pull down, enzymatic study)
HPRD (in vitro, two hybrid, in vivo)

		SGK1	MAPK7
Gene Name		serum/glucocorticoid regulated kinase 1	mitogen-activated protein kinase 7
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Cytosol Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity	MAP Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process Response To Stress Cellular Response To DNA Damage Stimulus Long-term Memory Regulation Of Blood Pressure Regulation Of Cell Migration Positive Regulation Of Transporter Activity Ion Transmembrane Transport Regulation Of Cell Proliferation Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Transmembrane Transport Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Cell Cycle Signal Transduction Peptidyl-serine Phosphorylation CAMP-mediated Signaling Cell Differentiation Negative Regulation Of CAMP Catabolic Process Negative Regulation Of Heterotypic Cell-cell Adhesion Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Stress-activated MAPK Cascade Negative Regulation Of NFAT Protein Import Into Nucleus Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Ion channel transport Stimuli-sensing channels	Signaling by GPCR Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence ERKs are inactivated Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling to ERK5 ERKs are inactivated Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Senescence-Associated Secretory Phenotype (SASP) NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade ERK/MAPK targets Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS		Body mass index (interaction) ( 23192594) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		31 interactors: BRAF CAMKK1 CARHSP1 CDKN1B CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAPK7 MAPT MLLT3 NDRG1 NEDD4 NEDD4L NEK6 PDK1 PDK2 PDPK1 PIK3CA PPP2CA RABAC1 RICTOR SLC1A3 SLC9A3R2 TMEM184C	27 interactors: ACTN4 APP C5orf30 EGLN3 ELK4 ETS1 FGF21 FOS GJA1 GOLGB1 MAP2K5 MEF2A MEF2C MEF2D MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RXRA SGK1 SH2D2A UBE2C YWHAB YWHAE ZBED6CL
Entrez ID		6446	5598
HPRD ID		04264	03952
Ensembl ID		ENSG00000118515	ENSG00000166484
Uniprot IDs		E9PR89 O00141	Q13164
PDB IDs		2R5T 3HDM 3HDN	2Q8Y 4B99 4IC7 4IC8
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Phosphatidylinositol-mediated Signaling Response To Growth Factor Fc-epsilon Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Signaling Negative Regulation Of Signal Transduction Signaling Regulation Of Protein Metabolic Process Response To Stress Apoptotic Process Cell Communication Programmed Cell Death Innate Immune Response Cell Death Death Regulation Of Signal Transduction Regulation Of Immune Response Response To Inorganic Substance Response To Metal Ion Response To Organic Substance Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Phosphorylation Cellular Response To Stress Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Immune Response Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Response To Peptide Hormone Immune System Process	Response To Fluid Shear Stress Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Apoptotic Process Programmed Cell Death Cellular Response To Growth Factor Stimulus Cell Death Death Positive Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Fluid Shear Stress Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Positive Regulation Of Behavioral Fear Response Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction By Phosphorylation Positive Regulation Of Gene Expression Regulation Of Cellular Component Organization Cellular Response To Stimulus Positive Regulation Of Cellular Biosynthetic Process Response To Stress Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Neurotrophin Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Proliferation Cardiac Conduction Regulation Of Signal Transduction Cardiovascular System Development Regulation Of RNA Metabolic Process Regulation Of MAPK Cascade Learning Or Memory Anatomical Structure Morphogenesis Signal Transduction Response To Hormone
Tagcloud ?		apical autophosphorylate autophosphorylation c4 cer ceramide cf cftr chloride coincidently conductance corrects cystic defect deltaf508 explants folding hypersecretion inactivates mutual pdk1 permit phosphorylates physiologically ser suppresses thr traffic trafficking
Tagcloud (Difference) ?		apical autophosphorylate autophosphorylation c4 cer ceramide cf cftr chloride coincidently conductance corrects cystic defect deltaf508 explants folding hypersecretion inactivates mutual pdk1 permit phosphorylates physiologically ser suppresses thr traffic trafficking
Tagcloud (Intersection) ?