KIF23 and USP8

Number of citations of the paper that reports this interaction (PMID 18329369)
45

Data Source:
HPRD (in vivo)

		KIF23	USP8
Gene Name		kinesin family member 23	ubiquitin specific peptidase 8
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Centrosome Spindle Cytosol Kinesin Complex Microtubule Focal Adhesion Midbody Intercellular Bridge Mitotic Spindle Centralspindlin Complex	Acrosomal Vesicle Nucleoplasm Cytoplasm Early Endosome Golgi Apparatus Cytosol Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATPase Activity	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding SH3 Domain Binding
	Biological Process	Mitotic Spindle Elongation Mitotic Cell Cycle Mitotic Cytokinesis Cytokinesis Microtubule-based Movement Blood Coagulation Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly	Mitotic Cytokinesis Endosome Organization Ras Protein Signal Transduction Cell Proliferation Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		Mitotic Telophase/Cytokinesis MHC class II antigen presentation Kinesins Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic M Phase Adaptive Immune System	Signaling by ERBB2 Downregulation of ERBB2:ERBB3 signaling misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ACTA1 ARF3 PLK1 RACGAP1 USP8 YWHAB YWHAG YWHAQ	30 interactors: BIRC6 CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 GRAP2 GRB2 KIF23 NBR1 PJA1 PLA2G2A RASGRF1 RNF41 SLBP SPP1 SRC STAM STAM2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ
Entrez ID		9493	9101
HPRD ID		05455	04405
Ensembl ID		ENSG00000137807	ENSG00000138592
Uniprot IDs		Q02241	P40818
PDB IDs		3VHX	1WHB 2A9U 2GFO 2GWF 3N3K
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitotic Cytokinesis Small GTPase Mediated Signal Transduction Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Regulation Of Organelle Organization Cytokinesis Positive Regulation Of Organelle Organization Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Stimulus Mitotic Cell Cycle Process Establishment Of Protein Localization Positive Regulation Of Intracellular Transport Mitotic Cell Cycle Regulation Of Protein Localization Membrane Organization Protein Localization Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Response To Stimulus Regulation Of Cellular Localization Cell Cycle Process Protein Targeting Cell Division Regulation Of Intracellular Transport Regulation Of Chromosome Segregation Cytokinesis, Initiation Of Separation Actomyosin Contractile Ring Assembly Cell Cycle Cellular Protein Localization Actomyosin Structure Organization Skeletal Muscle Fiber Adaptation Activation Of APC-Cdc20 Complex Activity G2/M Transition Of Mitotic Cell Cycle Protein Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Division Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Death Regulation Of Establishment Of Protein Localization Polar Body Extrusion After Meiotic Divisions Cell Proliferation Positive Regulation Of Transport	Cell Separation After Cytokinesis Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Mitotic Metaphase Plate Congression Metaphase Plate Congression Regulation Of Mitotic Spindle Organization Establishment Of Chromosome Localization Vacuolar Transport Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Cell Cycle Process Regulation Of Centrosome Duplication Cell Cycle Mitotic Nuclear Division Regulation Of Centrosome Cycle Mitotic Cell Cycle Process Endosomal Transport Regulation Of Organelle Organization Nucleus Organization Mitotic Cell Cycle Regulation Of Cell Division Regulation Of Microtubule Cytoskeleton Organization Cell Division Membrane Organization Regulation Of Microtubule-based Process Regulation Of Cell Cycle Process Intracellular Transport Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Chromosome Segregation Negative Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Nuclear Division Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Establishment Of Localization In Cell Regulation Of Cytoskeleton Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Organelle Localization Regulation Of ERBB Signaling Pathway Virion Assembly Viral Life Cycle Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Regulation Of Cellular Process Cellular Protein Catabolic Process Protein Transport
Tagcloud ?		alveolar astrocyte causing challenges col6a3 comparisons counting cpg cut epigenetic gbm gdna germ glioblastoma htb k27 lox lymphocyte lymphocytic methylation methyltransferase modifications mscc multiforme pbk percentages possessed regard summarized	ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Difference) ?		alveolar astrocyte causing challenges col6a3 comparisons counting cpg cut epigenetic gbm gdna germ glioblastoma htb k27 lox lymphocyte lymphocytic methylation methyltransferase modifications mscc multiforme pbk percentages possessed regard summarized	ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Intersection) ?