TUBG1 and CPAP

Number of citations: 47 (PubMedID 11003675)
Data Source: HPRD (in vivo)

		TUBG1	CPAP
Name		tubulin gamma 1	centrosome assembly and centriole elongation protein
Structure
GO Annotations	Cellular Component	Pericentriolar Material Condensed Nuclear Chromosome Gamma-tubulin Complex Gamma-tubulin Ring Complex Nucleus Cytoplasm Centrosome Centriole Spindle Polar Microtubule Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Cilium Microtubule Cytoskeleton Cell Leading Edge Ciliary Basal Body Neuron Projection Apical Part Of Cell Recycling Endosome Non-motile Cilium Mitotic Spindle Microtubule	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Microtubule Gamma-tubulin Small Complex Ciliary Basal Body Procentriole Replication Complex
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Identical Protein Binding Microtubule Nucleator Activity	Transcription Coactivator Activity Protein Binding Tubulin Binding Protein Kinase Binding Protein Domain Specific Binding Identical Protein Binding Gamma-tubulin Binding
	Biological Process	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Microtubule Nucleation Mitotic Spindle Organization Cytoplasmic Microtubule Organization	Microtubule Nucleation Centriole Replication Smoothened Signaling Pathway Astral Microtubule Nucleation Motile Cilium Assembly Positive Regulation Of DNA-templated Transcription Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Centriole Replication Positive Regulation Of Centriole Replication Microtubule Polymerization Centrosome Duplication Cell Division Regulation Of Mitotic Spindle Organization Cilium Assembly Centriole Elongation Centriole Assembly Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Organelle Assembly Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of Centriole Elongation Positive Regulation Of Establishment Of Protein Localization Non-motile Cilium Assembly Positive Regulation Of Spindle Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain AURKA Activation by TPX2
Drugs		Vinblastine	None
Diseases		None	Primary microcephaly (MCPH) Seckel syndrome
GWAS		Apolipoprotein A1 levels ( 32203549 ) HDL cholesterol levels ( 32203549 )	No GWAS studies recorded
Novel Interactors		6 novel interactors: CTRL PHB1 RARA RND2 SGCA WNT3	None recorded
Interacting Genes		31 interacting genes: APP BRCA1 CEBPA CNTN2 CPAP CUL4A DDX41 ERCC3 IKBKG KIF14 KRT18 KRT19 MARK4 NAPG NDE1 OGT PCNT PIK3R1 PLK1 PXN RACGAP1 RACK1 RASSF1 RNF19A RPGR SPATC1 TUBA1B TUBA3C TUBB4B TUBGCP3 TUBGCP4	16 interacting genes: ATN1 BCCIP CIC CREBBP EPB41 FBXO7 GFI1B LAG3 LYST MTDH SHANK3 STAT5A STAT5B TUBG1 YWHAG YWHAZ
Entrez ID		7283	55835
HPRD ID		01853	09876
Ensembl ID		ENSG00000131462	ENSG00000151849
Uniprot IDs		P23258	A8K8P1 F6VUX8 Q9HC77
PDB IDs		1Z5V 1Z5W 3CB2 6V5V 6V6S 7AS4 7QJ0 7QJ1 7QJ2 7QJ3 7QJ4 7QJ5 7QJ6 7QJ7 7QJ8 7QJ9 7QJA 7QJB 7QJC 7QJD 7QJE 8Q62 8RX1 8VA2 8VRD 8VRJ 8VRK 9H9P	5EIB 5ITZ 7Q1E 7Q1F 7Z0F 7Z0G
GO Terms Enriched among Interactors		Microtubule-based Process Cytoskeleton Microtubule Cytoskeleton Organization Cytoskeleton Organization Microtubule Organelle Organization Microtubule Organizing Center Microtubule Nucleation Gamma-tubulin Binding Structural Constituent Of Cytoskeleton Centrosome Regulation Of Cell Cycle Positive Regulation Of Proteolysis Mitotic Cell Cycle Microtubule Cytoskeleton Gamma-tubulin Complex Intracellular Signal Transduction Cytoplasm Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Programmed Cell Death Signal Transduction Supramolecular Fiber Organization Protein Domain Specific Binding Spindle Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Cell Cycle Process Spindle Pole Spindle Midzone Spindle Organization Positive Regulation Of Gene Expression Microtubule Organizing Center Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Cell Division Regulation Of Response To Endoplasmic Reticulum Stress Midbody Regulation Of Protein Metabolic Process Microtubule Polymerization Or Depolymerization Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Hemopoiesis Regulation Of Cellular Response To Stress Substrate Adhesion-dependent Cell Spreading	Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Cell Killing Leukocyte Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Lymphocyte Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Development Of Secondary Sexual Characteristics Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Lymphocyte Activation Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Interleukin-2 Production Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Leukocyte Activation Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Gamma-delta T Cell Differentiation Mucosa-associated Lymphoid Tissue Development Peyer's Patch Development Luteinization Negative Regulation Of Erythrocyte Differentiation Activated T Cell Proliferation Regulation Of Immune System Process Regulation Of Hemopoiesis Positive Regulation Of Cell Killing Taurine Metabolic Process Positive Regulation Of Natural Killer Cell Differentiation Regulation Of Innate Immune Response Negative Regulation Of Cell Activation Regulation Of Lymphocyte Differentiation Positive Regulation Of Gamma-delta T Cell Activation Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Regulation Of Cell Development Regulation Of Natural Killer Cell Differentiation Regulation Of Lymphocyte Activation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Immune Effector Process Negative Regulation Of Immune System Process Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Developmental Process Myeloid Cell Apoptotic Process Positive Regulation Of B Cell Differentiation Regulation Of Immune Response Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Innate Immune Response