TUBG1 and TUBB4B

Number of citations of the paper that reports this interaction (PMID 14594945)
21

Data Source:
HPRD (in vitro)

		TUBG1	TUBB4B
Gene Name		tubulin, gamma 1	tubulin, beta 4B class IVb
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Pericentriolar Material Condensed Nuclear Chromosome Gamma-tubulin Complex Cytoplasm Centrosome Centriole Polar Microtubule Cytosol Cytoplasmic Microtubule Cell Leading Edge Nonmotile Primary Cilium Ciliary Basal Body Apical Part Of Cell Recycling Endosome	Nucleus Cytosol Cytoskeleton Microtubule Vesicle Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding	Double-stranded RNA Binding GTPase Activity Structural Constituent Of Cytoskeleton GTP Binding MHC Class I Protein Binding Unfolded Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Organelle Organization Microtubule Nucleation Cytoplasmic Microtubule Organization	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Folding Movement Of Cell Or Subcellular Component Organelle Organization Natural Killer Cell Mediated Cytotoxicity Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Spindle Assembly Protein Polymerization Transmembrane Transport
Pathways		Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Recruitment of NuMA to mitotic centrosomes Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes	Transport of connexons to the plasma membrane Hedgehog 'off' state Formation of tubulin folding intermediates by CCT/TriC Regulation of PLK1 Activity at G2/M Transition Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Gap junction trafficking and regulation Recruitment of mitotic centrosome proteins and complexes Orphan transporters Gap junction assembly Gap junction trafficking Factors involved in megakaryocyte development and platelet production Resolution of Sister Chromatid Cohesion Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes M Phase Intraflagellar transport Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Protein folding Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Signaling by Hedgehog Chaperonin-mediated protein folding Centrosome maturation
Drugs			Albendazole Mebendazole Epothilone D Epothilone B
Diseases
GWAS
Protein-Protein Interactions		24 interactors: BRCA1 CENPJ CNTN2 IKBKG KRT18 KRT19 MARK4 NAPG NDE1 OLA1 PCNT PIK3R1 PLK1 PXN RACGAP1 RASSF1 RNF19A RPGR SPATC1 TUBA1B TUBA3C TUBB4B TUBGCP3 TUBGCP4	13 interactors: ACD CDKN2A DLEU1 DLST ENOX2 POT1 PSME1 SCG2 SOCS6 SOCS7 TERF1 TINF2 TUBG1
Entrez ID		7283	10383
HPRD ID		01853	04043
Ensembl ID		ENSG00000131462	ENSG00000188229
Uniprot IDs		P23258	P68371
PDB IDs		1Z5V 1Z5W 3CB2
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Microtubule Cytoskeleton Organization Cytoskeleton Organization G2/M Transition Of Mitotic Cell Cycle Protein Polymerization Cellular Protein Complex Assembly Organelle Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Cell Cycle Process Microtubule Nucleation Cellular Component Assembly Cellular Macromolecular Complex Assembly Microtubule Polymerization Mitotic Cell Cycle Process Protein Complex Assembly Mitotic Cell Cycle Microtubule Polymerization Or Depolymerization Centrosome Organization Microtubule Organizing Center Organization Organelle Assembly Regulation Of Protein Stability Centrosome Cycle 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Cell Division Movement Of Cell Or Subcellular Component Regulation Of Centriole Replication Regulation Of Cell Cycle Process Protein Stabilization Neural Precursor Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Localization Negative Regulation Of Cell Death Spindle Organization Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Cellular Response To Growth Hormone Stimulus Cytoskeleton-dependent Intracellular Transport Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cell Death Centrosome Duplication G2 DNA Damage Checkpoint Neuron Migration Regulation Of Microtubule-based Process Response To Growth Hormone Regulation Of Centrosome Duplication Positive Regulation Of Protein Metabolic Process	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Replication Negative Regulation Of Transferase Activity Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of DNA Metabolic Process Regulation Of DNA Replication Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomerase Activity Negative Regulation Of Catalytic Activity Telomere Maintenance Regulation Of Chromosome Organization Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein Kinase Activity Protein Localization To Chromosome, Telomeric Region Telomere Capping Regulation Of Catalytic Activity Negative Regulation Of Kinase Activity Positive Regulation Of Telomerase Activity Chromosome Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Growth Telomere Maintenance Via Telomerase Positive Regulation Of Proteolysis Regulation Of Proteolysis Positive Regulation Of Telomere Maintenance Negative Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Organelle Organization Positive Regulation Of Endopeptidase Activity Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Peptidase Activity Regulation Of Organelle Organization RNA-dependent DNA Replication Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		bipolar dcx disorganization dync1h1 electroporation ganglial gyral inputs interchangeability kif2a kif5c malformations mcd mcds polarization polymicrogyria postmitotic radial rescue round stereotyped tbr2 tuba1a tubb2b tubb3 tubb5 tubulin tubulins utero
Tagcloud (Difference) ?		bipolar dcx disorganization dync1h1 electroporation ganglial gyral inputs interchangeability kif2a kif5c malformations mcd mcds polarization polymicrogyria postmitotic radial rescue round stereotyped tbr2 tuba1a tubb2b tubb3 tubb5 tubulin tubulins utero
Tagcloud (Intersection) ?