SLC16A10 and RACGAP1

Number of citations of the paper that reports this interaction (PubMedID 11278976)
0

Data Source:
HPRD (in vivo, in vitro)

		SLC16A10	RACGAP1
Description		solute carrier family 16 member 10	Rac GTPase activating protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Cell Junction	Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Mitochondrion Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Cleavage Furrow Spindle Midzone Extracellular Exosome Mitotic Spindle Flemming Body Centralspindlin Complex
	Molecular Function	L-tyrosine Transmembrane Transporter Activity Protein Binding Amino Acid Transmembrane Transporter Activity Aromatic Amino Acid Transmembrane Transporter Activity L-phenylalanine Transmembrane Transporter Activity L-tryptophan Transmembrane Transporter Activity Thyroid Hormone Transmembrane Transporter Activity Transmembrane Transporter Activity Carboxylic Acid Transmembrane Transporter Activity	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Zinc Ion Binding Lipid Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding
	Biological Process	Amino Acid Transmembrane Transport Thyroid Hormone Generation Amino Acid Transport Aromatic Amino Acid Transport Phenylalanine Transport Tryptophan Transport Tyrosine Transport Transmembrane Transport Thyroid Hormone Transport Thyroid-stimulating Hormone Secretion Carboxylic Acid Transmembrane Transport	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Monoatomic Ion Transport Signal Transduction Rho Protein Signal Transduction Spermatogenesis Neuroblast Proliferation Cell Differentiation Erythrocyte Differentiation Positive Regulation Of Cytokinesis Regulation Of Embryonic Development Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Sulfate Transmembrane Transport
Pathways		Amino acid transport across the plasma membrane	MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RAC3 GTPase cycle Kinesins
Drugs
Diseases
GWAS		Bisphosphonate-associated atypical femoral fracture ( 31006051) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic traits ( 21886157) Metabolite levels ( 22286219 23823483) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Tyrosine levels ( 31560688) Ulcerative colitis ( 28067908)
Interacting Genes		4 interacting genes: FUNDC2 INSIG2 RACGAP1 TMEM14B	32 interacting genes: AURKB BYSL CDK1 CDK3 CHN2 ECT2 HIF1A KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PLK1 PPP2CA PPP2R5E PRC1 PRSS23 PTPA RAC1 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TRAF3IP3 TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG
Entrez ID		117247	29127
HPRD ID		09613	05402
Ensembl ID		ENSG00000112394	ENSG00000161800
Uniprot IDs		Q8TF71	B2RE34 Q9H0H5
PDB IDs			2OVJ 3W6R 3WPQ 3WPS 4B6D 5C2J 5C2K
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-3,4,5-trisphosphate Binding Neural Precursor Cell Proliferation Centralspindlin Complex Actomyosin Contractile Ring Assembly SREBP-SCAP-Insig Complex SREBP-SCAP Complex Retention In Endoplasmic Reticulum Negative Regulation Of SREBP Signaling Pathway Sulfate Transmembrane Transport Spindle Midzone Assembly Lipid Binding Mitotic Spindle Midzone Assembly Regulation Of SREBP Signaling Pathway Maintenance Of Protein Localization In Endoplasmic Reticulum Cranial Suture Morphogenesis Response To Sterol Depletion SREBP Signaling Pathway Cellular Response To Sterol Depletion Intracellular Triglyceride Homeostasis Oxysterol Binding Cortical Actin Cytoskeleton Organization Flemming Body Regulation Of Attachment Of Spindle Microtubules To Kinetochore Alpha-tubulin Binding Gamma-tubulin Binding Positive Regulation Of Cytokinesis Cell Population Proliferation Beta-tubulin Binding Cytokinetic Process Spindle Midzone NLS-bearing Protein Import Into Nucleus Negative Regulation Of Steroid Metabolic Process Cholesterol Biosynthetic Process Middle Ear Morphogenesis Positive Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Fatty Acid Metabolic Process Craniofacial Suture Morphogenesis Negative Regulation Of Fatty Acid Biosynthetic Process Maintenance Of Protein Localization In Organelle Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process ER-nucleus Signaling Pathway Sterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Metabolic Process Protein Sequestering Activity Acylglycerol Homeostasis Triglyceride Homeostasis Porphyrin-containing Compound Metabolic Process Tetrapyrrole Biosynthetic Process	Spindle Microtubule Intracellular Signal Transduction Spindle Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Midbody Spindle Midzone Assembly Protein Phosphatase Type 2A Complex Mitotic Spindle Elongation Microtubule Cytoskeleton Organization Involved In Mitosis Nucleotide Binding Mitotic Cell Cycle Signal Transduction Mitotic Cytokinesis Microtubule Cytoskeleton Regulation Of Protein Localization To Nucleus Regulation Of Attachment Of Spindle Microtubules To Kinetochore Centralspindlin Complex Microtubule-based Process Cytosol Microtubule Cytoskeleton Organization Cell Division Regulation Of Cell Division Regulation Of Protein Modification Process Cytoskeleton-dependent Cytokinesis Mitotic Spindle Organization Spindle Elongation Cytoskeleton Protein Serine Kinase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Positive Regulation Of Protein Modification Process MAPK Cascade Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Cytokinesis Regulation Of Phosphorus Metabolic Process Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Segregation Intracellular Signaling Cassette Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Intracellular Signal Transduction Phosphorylation-dependent Protein Binding Cell Cycle G2/M Phase Transition Protein Kinase Binding Mitotic Nuclear Membrane Disassembly Mitotic Spindle Midzone Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization
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