PHPT1 and TINF2

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		PHPT1	TINF2
Gene Name		phosphohistidine phosphatase 1	TERF1 (TRF1)-interacting nuclear factor 2
Image
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Perinucleolar Chromocenter Nuclear Matrix
	Molecular Function	Phosphoprotein Phosphatase Activity Phosphohistidine Phosphatase Activity Calcium Channel Inhibitor Activity Ion Channel Binding	DNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Protein Dephosphorylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Peptidyl-histidine Dephosphorylation Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Lyase Activity Positive Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of ATP Citrate Synthase Activity	Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein ADP-ribosylation Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region
Pathways			Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ATXN1 ATXN1L DNMT3L PPP1R16A TINF2	88 interactors: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CTTN DBN1 DCX DHFRL1 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM POT1 PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790
Entrez ID		29085	26277
HPRD ID		17849	16056
Ensembl ID		ENSG00000054148	ENSG00000092330
Uniprot IDs		Q9NRX4 Q9P019	B4DFJ1 Q9BSI4
PDB IDs		2AI6 2HW4 2NMM 2OZW 2OZX	3BQO 3BU8
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Biosynthetic Process Lung Alveolus Development Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein ADP-ribosylation Regulation Of Protein ADP-ribosylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Protein Glycosylation Lung Development Negative Regulation Of Gene Expression Respiratory Tube Development Respiratory System Development Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Regulation Of Hematopoietic Stem Cell Proliferation Telomere Assembly Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Maintenance Regulation Of Protein Glycosylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Glycoprotein Metabolic Process DNA Methylation On Cytosine Nitrogen Compound Metabolic Process Regulation Of Telomere Maintenance Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression By Genetic Imprinting Regulation Of Glycoprotein Biosynthetic Process Protein Localization To Chromosome Tube Development Telomere Maintenance Via Telomere Lengthening Genetic Imprinting Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of DNA Replication Regulation Of Metabolic Process DNA Methylation Visual Learning Positive Regulation Of Metabolic Process Gene Expression Visual Behavior DNA Metabolic Process Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Stem Cell Proliferation	Negative Regulation Of Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Glycolytic Process Protection From Non-homologous End Joining At Telomere Carbohydrate Catabolic Process Negative Regulation Of DNA Replication Telomere Assembly Catabolic Process Negative Regulation Of DNA Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Catalytic Activity Positive Regulation Of Telomerase Activity Pyruvate Metabolic Process Telomere Maintenance Telomere Maintenance Via Telomerase Pathogenesis Generation Of Precursor Metabolites And Energy Glucose Metabolic Process Positive Regulation Of Single-stranded Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Chromosome Organization Small Molecule Metabolic Process Organic Acid Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Catalytic Activity Carboxylic Acid Metabolic Process Age-dependent Telomere Shortening Telomeric Loop Formation Nervous System Development Regulation Of Signaling Positive Regulation Of DNA Biosynthetic Process Glycogen Metabolic Process RNA-dependent DNA Replication Nucleoside Metabolic Process Telomere Maintenance Via Telomere Shortening Regulation Of Signal Transduction Hexose Metabolic Process Cellular Process Regulation Of DNA Replication Monocarboxylic Acid Metabolic Process Cellular Carbohydrate Metabolic Process Response To Stimulus Protein Localization To Chromosome Organelle Organization Telomere Maintenance Via Telomere Lengthening Polysaccharide Metabolic Process
Tagcloud ?			acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Difference) ?			acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Intersection) ?