PHPT1 and DNMT3L

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		PHPT1	DNMT3L
Gene Name		phosphohistidine phosphatase 1	DNA (cytosine-5-)-methyltransferase 3-like
Image
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Nucleus Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Phosphohistidine Phosphatase Activity Calcium Channel Inhibitor Activity Ion Channel Binding	Protein Binding Enzyme Activator Activity Enzyme Binding Metal Ion Binding
	Biological Process	Protein Dephosphorylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Peptidyl-histidine Dephosphorylation Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Lyase Activity Positive Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of ATP Citrate Synthase Activity	DNA Methylation Regulation Of Gene Expression By Genetic Imprinting Spermatogenesis Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Positive Regulation Of Catalytic Activity Negative Regulation Of Transcription, DNA-templated
Pathways			Epigenetic regulation of gene expression DNA methylation
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ATXN1 ATXN1L DNMT3L PPP1R16A TINF2	11 interactors: DNMT3A DNMT3B GSK3B HDAC1 HIST2H2AC HIST2H2BE HIST2H3C HIST2H4A NUDT21 PHPT1 RSL24D1
Entrez ID		29085	29947
HPRD ID		17849	09417
Ensembl ID		ENSG00000054148	ENSG00000142182
Uniprot IDs		Q9NRX4 Q9P019	Q9UJW3
PDB IDs		2AI6 2HW4 2NMM 2OZW 2OZX	2PV0 2PVC 2QRV
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Biosynthetic Process Lung Alveolus Development Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein ADP-ribosylation Regulation Of Protein ADP-ribosylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Protein Glycosylation Lung Development Negative Regulation Of Gene Expression Respiratory Tube Development Respiratory System Development Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Regulation Of Hematopoietic Stem Cell Proliferation Telomere Assembly Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Maintenance Regulation Of Protein Glycosylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Glycoprotein Metabolic Process DNA Methylation On Cytosine Nitrogen Compound Metabolic Process Regulation Of Telomere Maintenance Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression By Genetic Imprinting Regulation Of Glycoprotein Biosynthetic Process Protein Localization To Chromosome Tube Development Telomere Maintenance Via Telomere Lengthening Genetic Imprinting Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of DNA Replication Regulation Of Metabolic Process DNA Methylation Visual Learning Positive Regulation Of Metabolic Process Gene Expression Visual Behavior DNA Metabolic Process Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Stem Cell Proliferation	DNA Methylation On Cytosine Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Silencing DNA Methylation DNA Modification Gene Silencing Regulation Of Gene Expression By Genetic Imprinting Genetic Imprinting S-adenosylmethioninamine Metabolic Process Hypermethylation Of CpG Island DNA Methylation On Cytosine Within A CG Sequence C-5 Methylation Of Cytosine S-adenosylhomocysteine Metabolic Process Methylation-dependent Chromatin Silencing Chromatin Organization Negative Regulation Of Biosynthetic Process Chromatin Silencing At RDNA Methylation Regulation Of DNA Methylation Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Cellular Response To Amino Acid Stimulus ATP-dependent Chromatin Remodeling Peptidyl-histidine Dephosphorylation Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development DNA Metabolic Process Response To Amino Acid Re-entry Into Mitotic Cell Cycle Histone H4-K20 Demethylation Negative Regulation Of ATP Citrate Synthase Activity Negative Regulation Of Neuron Maturation Nucleosome Assembly Nucleobase-containing Compound Metabolic Process Chromatin Assembly Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Nucleosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Chromatin Assembly Or Disassembly Negative Regulation Of Megakaryocyte Differentiation Cellular Response To Interleukin-3 Protein-DNA Complex Assembly
Tagcloud ?			add adds atrx autoinhibition autoinhibitory catalytically connection disrupts embryogenesis enzymatic h3k4 h3k4me0 h3k4me3 imprinting inheritance methyltransferase methyltransferases novo paralogue positioning recognizes releases stimulates tail unexpected unmethylated
Tagcloud (Difference) ?			add adds atrx autoinhibition autoinhibitory catalytically connection disrupts embryogenesis enzymatic h3k4 h3k4me0 h3k4me3 imprinting inheritance methyltransferase methyltransferases novo paralogue positioning recognizes releases stimulates tail unexpected unmethylated
Tagcloud (Intersection) ?