GRIN2A and AP1M1

Number of citations of the paper that reports this interaction (PubMedID 15254094)
38

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GRIN2A	AP1M1
Description		glutamate ionotropic receptor NMDA type subunit 2A	adaptor related protein complex 1 subunit mu 1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane Synaptic Membrane Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Plasma Membrane Membrane AP-1 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Specific Granule Membrane Synapse Extracellular Exosome
	Molecular Function	Amyloid-beta Binding NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Zinc Ion Binding Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Metal Ion Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding Clathrin Adaptor Activity
	Biological Process	Startle Response Response To Amphetamine Monoatomic Ion Transport Calcium Ion Transport Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Brain Development Learning Or Memory Learning Memory Visual Learning Response To Xenobiotic Stimulus Response To Wounding Sensory Perception Of Pain Calcium-mediated Signaling Neurogenesis Protein Catabolic Process Sleep Directional Locomotion Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Sodium Ion Transmembrane Transport Locomotion Negative Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Dopamine Metabolic Process Serotonin Metabolic Process Positive Regulation Of Apoptotic Process Response To Ethanol Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Protein Localization To Postsynaptic Membrane Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Amyloid-beta Positive Regulation Of Excitatory Postsynaptic Potential	Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Melanosome Organization Endosome To Melanosome Transport Platelet Dense Granule Organization Melanosome Assembly
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Neurexins and neuroligins Synaptic adhesion-like molecules MECP2 regulates neuronal receptors and channels Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation
Drugs		Glutamic acid Glycine Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Dextropropoxyphene Acamprosate Donepezil Guaifenesin Felbamate Memantine Halothane Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bevacizumab-induced composite toxicity (either hypertension or proteinuria) ( 34616010) Bipolar disorder ( 33263727 31043756 34002096) Bipolar I disorder ( 31043756) Chronic kidney disease ( 26420894) Clostridioides difficle infection ( 33841421) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Copper levels ( 26025379) Daytime nap ( 33568662) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Hallux valgus ( 32131869) Hepatitis B ( 22004137) Laryngeal squamous cell carcinoma ( 25194280) Lung function (FVC) ( 30804560) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260 29483656 28991256 25056061) Tenofovir clearance in HIV infection ( 26148204) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist circumference adjusted for BMI (smoking interaction) ( 28443625)	Coronary artery disease ( 33020668)
Interacting Genes		32 interacting genes: ACTN1 AKT1 AP1M1 AP2M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CASK CDK5 CSNK2A1 CSNK2A2 CSNK2B DLG1 DLG2 DLG3 DLG4 DLGAP1 FYN GRIN1 GRIN3A GRIN3B IL16 NEDD4 PATJ PLCG1 PRKCA PTK2B PTPN4 RGS3 SPTAN1 SRC	103 interacting genes: AMOT AP1M2 AP2B1 ARFRP1 ARL6IP4 ARNT2 ATF4 AXIN2 BACH2 BCAR3 BRCA1 C7orf57 CASP8 CCDC33 CEP57L1 CORO7 CTLA4 DCX DISC1 DVL2 DZIP3 EFEMP2 EHD2 ENTR1 ETV6 EVI5L FAM219B FAM9B FKBP7 FXR1 FXR2 GAK GCSAM GRIN2A GRIN2B HNRNPC HOOK1 HOOK2 IKZF1 KIF13A KIF24 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 LAMP1 LDOC1 LNX1 LRATD2 LRMDA LZTS1 LZTS2 MDK MEA1 MID2 MTF1 MYOD1 NECAB1 NKAP NKAPD1 OLIG3 PAX6 PHC2 PICK1 PIGR PNMA5 PURB RAPGEF3 ROPN1 RP9 RSPH14 RUNDC3A SDCBP2 SELP SLC2A4 SP4 SPATA6 SRPK2 SSX2IP TEPSIN TFIP11 TGOLN2 THAP6 TIFA TNIP1 TRIM27 TRIM41 UBC VAMP4 VANGL2 ZBTB14 ZBTB3 ZBTB43 ZBTB44 ZBTB8A ZCCHC17 ZNF19 ZNF219 ZNF276 ZNF552 ZNF655 ZNF8 ZSCAN16
Entrez ID		2903	8907
HPRD ID		00698	04639
Ensembl ID		ENSG00000183454	ENSG00000072958
Uniprot IDs		A0A890YTL4 Q12879 Q547U9 Q59EW6	B3KNH5 Q59EK3 Q9BXS5
PDB IDs		3NFL 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA 6IRA 6IRF 6IRG 6IRH 7EOQ 7EOR 7EOS 7EOT 7EOU 7EU7 8E99 8JIZ 8JJ0 8JJ1 8JJ2 8VUH 8VUJ 8VUL 8VUN 8VUQ 8VUR 8VUT
Enriched GO Terms of Interacting Partners?		Ionotropic Glutamate Receptor Binding Postsynaptic Density Regulation Of Metal Ion Transport Synapse Regulation Of Monoatomic Ion Transport Cytosol Cell Junction Modulation Of Chemical Synaptic Transmission Regulation Of Calcium Ion Transport Chemical Synaptic Transmission Glutamate Receptor Signaling Pathway Glutamatergic Synapse Regulation Of Transport NMDA Selective Glutamate Receptor Complex Calcium Ion Transport Trans-synaptic Signaling Postsynaptic Density Membrane Synaptic Signaling Ionotropic Glutamate Receptor Signaling Pathway Plasma Membrane Protein Kinase CK2 Complex Glycine-gated Cation Channel Activity Protein Kinase Activity Regulation Of Synaptic Plasticity Ligand-gated Ion Channel Signaling Pathway Regulation Of Membrane Potential Neuron Projection Metal Ion Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Kinase Activity Receptor Clustering Regulation Of Protein Localization To Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Phosphate-containing Compound Metabolic Process Regulation Of Cellular Localization Regulation Of Biological Quality Protein Localization To Synapse Protein Serine/threonine Kinase Activity Regulation Of Protein Localization To Plasma Membrane Regulation Of Synapse Organization NMDA Glutamate Receptor Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Monoatomic Cation Transport Transmembrane Transporter Binding Cell-cell Signaling GMP Kinase Activity Protein Phosphorylation Regulation Of Signaling Neuromuscular Junction Regulation Of Cell Communication	Identical Protein Binding Protein Binding Zinc Ion Binding Regulation Of RNA Metabolic Process DNA Binding Post-Golgi Vesicle-mediated Transport Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Domain Specific Binding Convergent Extension Involved In Neural Plate Elongation Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Trans-Golgi Network Membrane Regulation Of Transcription By RNA Polymerase II Clathrin-coated Endocytic Vesicle Cellular Localization Intracellular Transport Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Synaptic Plasticity Negative Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Protein Complex Involved In Cell Adhesion Microtubule Convergent Extension Involved In Organogenesis Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion FHF Complex Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Regulatory T Cell Differentiation Convergent Extension Involved In Gastrulation Dentate Gyrus Development Protein Localization To Membrane Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity NMDA Glutamate Receptor Activity Regulation Of RNA Biosynthetic Process
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