GRIN2A and DLGAP1

Number of citations of the paper that reports this interaction (PMID 9286858)
15

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GRIN2A	DLGAP1
Gene Name		glutamate receptor, ionotropic, N-methyl D-aspartate 2A	discs, large (Drosophila) homolog-associated protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Presynaptic Membrane Postsynaptic Membrane Neuronal Postsynaptic Density	Cellular_component Cell Junction Postsynaptic Membrane Neuronal Postsynaptic Density
	Molecular Function	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Protein Binding Zinc Ion Binding	Protein Binding
	Biological Process	Startle Response Response To Amphetamine Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Learning Or Memory Memory Protein Localization Visual Learning Response To Wounding Sensory Perception Of Pain Neurogenesis Sleep Directional Locomotion Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Negative Regulation Of Protein Catabolic Process Dopamine Metabolic Process Serotonin Metabolic Process Response To Drug Positive Regulation Of Apoptotic Process Response To Ethanol Regulation Of Synaptic Plasticity Regulation Of Sensory Perception Of Pain Regulation Of Excitatory Postsynaptic Membrane Potential Calcium Ion Transmembrane Transport	Synaptic Transmission
Pathways		Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Glycine Meperidine Felbamate Memantine Halothane Tenocyclidine
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Hepatitis B ( 22004137) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Cardiac Troponin-T levels ( 23247143) Eating disorders ( 22911880) Economic and political preferences (time) ( 22566634) Obesity-related traits ( 23251661)
Protein-Protein Interactions		27 interactors: ACTN1 AP1M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CASK CDK5 DLG1 DLG2 DLG3 DLG4 DLGAP1 FYN GRIN1 GRIN3A GRIN3B IL16 INADL NEDD4 PLCG1 PRKCA PTK2B PTPN4 RGS3 SPTAN1 SRC	21 interactors: APC DLG1 DLG2 DLG3 DLG4 DLGAP2 DLGAP3 DYNLL1 DYNLL2 GRB2 GRIN2A GRIN2C ITSN1 ITSN2 KCNA4 MYO5A SHANK1 SHANK2 SHANK3 SORBS2 TANC1
Entrez ID		2903	9229
HPRD ID		00698	09260
Ensembl ID		ENSG00000183454	ENSG00000170579
Uniprot IDs		B4DII7 F5GZ52 Q12879 Q547U9 Q59EW6	A8MXQ8 B7Z2J5 O14490
PDB IDs		3NFL
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Protein Localization To Synapse Chemotaxis Neuron Projection Development Receptor Localization To Synapse Neuron Development Locomotion Axon Guidance Regulation Of Ion Transport Neuron Differentiation Cell Projection Organization Response To External Stimulus Protein Autophosphorylation Receptor Clustering Generation Of Neurons Axonogenesis Nucleotide Phosphorylation Neurogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Membrane Organization Neuron Projection Morphogenesis Movement Of Cell Or Subcellular Component Regulation Of Synaptic Plasticity Nervous System Development Cell Morphogenesis Involved In Differentiation Regulation Of Calcium Ion Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-cell Junction Organization Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Cell Projection Morphogenesis Cell Development Peptidyl-serine Phosphorylation Cell Part Morphogenesis Phosphorylation Signaling Regulation Of Neuronal Synaptic Plasticity Regulation Of Membrane Potential Cell Communication Cell Activation Phosphate-containing Compound Metabolic Process Glutamate Receptor Signaling Pathway Cell Differentiation Response To Stimulus Immune Response Regulation Of Cell Projection Organization Regulation Of Synaptic Transmission Epidermal Growth Factor Receptor Signaling Pathway	Cell-cell Signaling Synaptic Transmission Protein Localization To Synapse Receptor Localization To Synapse Nervous System Development Vocalization Behavior Receptor Clustering Learning Dendritic Spine Organization Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Cell Morphogenesis Involved In Neuron Differentiation Locomotion Social Behavior Neuron Projection Morphogenesis Membrane Depolarization Neuron Development Signaling Cell Communication Learning Or Memory Cell Morphogenesis Involved In Differentiation Regulation Of Membrane Potential Dendritic Spine Morphogenesis Cognition Nucleotide Phosphorylation Neuron Differentiation Regulation Of Signaling Cell Projection Organization Neuron Projection Development Neurological System Process Cell Projection Morphogenesis Synapse Organization Cell Part Morphogenesis Dendritic Spine Development Neurogenesis Behavior Protein Localization To Membrane Anatomical Structure Development System Development Regulation Of Ion Transmembrane Transport Anatomical Structure Morphogenesis Cell Morphogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity Single-organism Behavior Generation Of Neurons Regulation Of Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Developmental Process Memory Multicellular Organismal Development
Tagcloud ?		6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta	18p11 aided blindness cataracts centimorgans chorioretinal clul1 compiled elastin emilin2 interfacer intronic lipin lpin2 microfibril mrcl3 mrlc2 myom1 myomesin myopia myosin myp2 pedigree positional prioritizing segregated tgifbeta underway zfp161
Tagcloud (Difference) ?		6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta	18p11 aided blindness cataracts centimorgans chorioretinal clul1 compiled elastin emilin2 interfacer intronic lipin lpin2 microfibril mrcl3 mrlc2 myom1 myomesin myopia myosin myp2 pedigree positional prioritizing segregated tgifbeta underway zfp161
Tagcloud (Intersection) ?