GRIN2A and GRIN3B

Number of citations of the paper that reports this interaction (PMID 12008020)
30

Data Source:
HPRD (in vivo, in vitro)

		GRIN2A	GRIN3B
Gene Name		glutamate receptor, ionotropic, N-methyl D-aspartate 2A	glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Presynaptic Membrane Postsynaptic Membrane Neuronal Postsynaptic Density	N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Neuronal Cell Body Postsynaptic Membrane
	Molecular Function	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Protein Binding Zinc Ion Binding	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Cation Channel Activity Calcium Channel Activity Glycine Binding Neurotransmitter Receptor Activity Neurotransmitter Binding
	Biological Process	Startle Response Response To Amphetamine Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Learning Or Memory Memory Protein Localization Visual Learning Response To Wounding Sensory Perception Of Pain Neurogenesis Sleep Directional Locomotion Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Negative Regulation Of Protein Catabolic Process Dopamine Metabolic Process Serotonin Metabolic Process Response To Drug Positive Regulation Of Apoptotic Process Response To Ethanol Regulation Of Synaptic Plasticity Regulation Of Sensory Perception Of Pain Regulation Of Excitatory Postsynaptic Membrane Potential Calcium Ion Transmembrane Transport	Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Protein Insertion Into Membrane Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport
Pathways		Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Glycine Meperidine Felbamate Memantine Halothane Tenocyclidine	L-Glutamic Acid Glycine Halothane Orphenadrine Tenocyclidine
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Hepatitis B ( 22004137) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Alzheimer's disease (late onset) ( 23571587)
Protein-Protein Interactions		27 interactors: ACTN1 AP1M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CASK CDK5 DLG1 DLG2 DLG3 DLG4 DLGAP1 FYN GRIN1 GRIN3A GRIN3B IL16 INADL NEDD4 PLCG1 PRKCA PTK2B PTPN4 RGS3 SPTAN1 SRC	2 interactors: DLG4 GRIN2A
Entrez ID		2903	116444
HPRD ID		00698	09444
Ensembl ID		ENSG00000183454	ENSG00000116032
Uniprot IDs		B4DII7 F5GZ52 Q12879 Q547U9 Q59EW6	O60391
PDB IDs		3NFL
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Protein Localization To Synapse Chemotaxis Neuron Projection Development Receptor Localization To Synapse Neuron Development Locomotion Axon Guidance Regulation Of Ion Transport Neuron Differentiation Cell Projection Organization Response To External Stimulus Protein Autophosphorylation Receptor Clustering Generation Of Neurons Axonogenesis Nucleotide Phosphorylation Neurogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Membrane Organization Neuron Projection Morphogenesis Movement Of Cell Or Subcellular Component Regulation Of Synaptic Plasticity Nervous System Development Cell Morphogenesis Involved In Differentiation Regulation Of Calcium Ion Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-cell Junction Organization Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Cell Projection Morphogenesis Cell Development Peptidyl-serine Phosphorylation Cell Part Morphogenesis Phosphorylation Signaling Regulation Of Neuronal Synaptic Plasticity Regulation Of Membrane Potential Cell Communication Cell Activation Phosphate-containing Compound Metabolic Process Glutamate Receptor Signaling Pathway Cell Differentiation Response To Stimulus Immune Response Regulation Of Cell Projection Organization Regulation Of Synaptic Transmission Epidermal Growth Factor Receptor Signaling Pathway	Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Membrane Depolarization Neuromuscular Process Learning Regulation Of Synaptic Plasticity Learning Or Memory Regulation Of Membrane Potential Cognition Regulation Of Synaptic Transmission Directional Locomotion Single-organism Behavior Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Maintenance Of Apical/basal Cell Polarity Receptor Localization To Synapse Synaptic Transmission Behavior Negative Regulation Of Receptor Internalization Locomotory Exploration Behavior Dendritic Spine Morphogenesis Maintenance Of Cell Polarity Synaptic Vesicle Maturation Vocalization Behavior Serotonin Metabolic Process Sleep Dendritic Spine Development Protein Localization To Synapse Cell-cell Signaling Negative Regulation Of Receptor-mediated Endocytosis Dendritic Spine Organization Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Cortical Actin Cytoskeleton Organization Exploration Behavior Postsynaptic Membrane Organization Regulation Of Sensory Perception Of Pain Establishment Or Maintenance Of Apical/basal Cell Polarity Startle Response Dopamine Metabolic Process Cortical Cytoskeleton Organization Neurological System Process Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Receptor Internalization Positive Regulation Of Excitatory Postsynaptic Membrane Potential Locomotion Golgi To Plasma Membrane Transport Response To Amphetamine Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Social Behavior
Tagcloud ?		6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta	asd autism compensation counteract de disability excitatory exploring grin1 grin2a grin2c grin2d hypofunction imbalance implicate instrumental intellectual neurodevelopment neurodevelopmental neurotransmission nmdars novo scz sequenced sporadic truncating
Tagcloud (Difference) ?		6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta	asd autism compensation counteract de disability excitatory exploring grin1 hypofunction imbalance implicate instrumental intellectual neurodevelopment neurodevelopmental neurotransmission nmdars novo scz sequenced sporadic truncating
Tagcloud (Intersection) ?		grin2a grin2c grin2d