GRIN2A and EML1

		GRIN2A	EML1
Description		glutamate ionotropic receptor NMDA type subunit 2A	EMAP like 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane Synaptic Membrane Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse	Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Mitotic Spindle Mitotic Spindle Pole Mitotic Spindle Midzone
	Molecular Function	Amyloid-beta Binding NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Zinc Ion Binding Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Metal Ion Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Calcium Ion Binding Protein Binding Microtubule Binding Tubulin Binding
	Biological Process	Startle Response Response To Amphetamine Monoatomic Ion Transport Calcium Ion Transport Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Brain Development Learning Or Memory Learning Memory Visual Learning Response To Xenobiotic Stimulus Response To Wounding Sensory Perception Of Pain Calcium-mediated Signaling Neurogenesis Protein Catabolic Process Sleep Directional Locomotion Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Sodium Ion Transmembrane Transport Locomotion Negative Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Dopamine Metabolic Process Serotonin Metabolic Process Positive Regulation Of Apoptotic Process Response To Ethanol Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Protein Localization To Postsynaptic Membrane Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Amyloid-beta Positive Regulation Of Excitatory Postsynaptic Potential	Microtubule Cytoskeleton Organization Hematopoietic Progenitor Cell Differentiation Mitotic Spindle Organization Neuroblast Proliferation Brain Development
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Neurexins and neuroligins Synaptic adhesion-like molecules MECP2 regulates neuronal receptors and channels Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Glutamic acid Glycine Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Dextropropoxyphene Acamprosate Donepezil Guaifenesin Felbamate Memantine Halothane Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bevacizumab-induced composite toxicity (either hypertension or proteinuria) ( 34616010) Bipolar disorder ( 33263727 31043756 34002096) Bipolar I disorder ( 31043756) Chronic kidney disease ( 26420894) Clostridioides difficle infection ( 33841421) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Copper levels ( 26025379) Daytime nap ( 33568662) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Hallux valgus ( 32131869) Hepatitis B ( 22004137) Laryngeal squamous cell carcinoma ( 25194280) Lung function (FVC) ( 30804560) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260 29483656 28991256 25056061) Tenofovir clearance in HIV infection ( 26148204) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist circumference adjusted for BMI (smoking interaction) ( 28443625)	Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Depression in smokers ( 30219690) Pulse pressure ( 27841878) Scalp hair shape ( 26926045) Visceral fat ( 30942860)
Interacting Genes		32 interacting genes: ACTN1 AKT1 AP1M1 AP2M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CASK CDK5 CSNK2A1 CSNK2A2 CSNK2B DLG1 DLG2 DLG3 DLG4 DLGAP1 FYN GRIN1 GRIN3A GRIN3B IL16 NEDD4 PATJ PLCG1 PRKCA PTK2B PTPN4 RGS3 SPTAN1 SRC	7 interacting genes: GRID1 GRID2 ISG20L2 MTDH PTEN TUBA1A UBE3A
Entrez ID		2903	2009
HPRD ID		00698	03613
Ensembl ID		ENSG00000183454	ENSG00000066629
Uniprot IDs		A0A890YTL4 Q12879 Q547U9 Q59EW6	O00423
PDB IDs		3NFL 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA 6IRA 6IRF 6IRG 6IRH 7EOQ 7EOR 7EOS 7EOT 7EOU 7EU7 8E99 8JIZ 8JJ0 8JJ1 8JJ2 8VUH 8VUJ 8VUL 8VUN 8VUQ 8VUR 8VUT	4CI8
Enriched GO Terms of Interacting Partners?		Ionotropic Glutamate Receptor Binding Postsynaptic Density Regulation Of Metal Ion Transport Synapse Regulation Of Monoatomic Ion Transport Cytosol Cell Junction Modulation Of Chemical Synaptic Transmission Regulation Of Calcium Ion Transport Chemical Synaptic Transmission Glutamate Receptor Signaling Pathway Glutamatergic Synapse Regulation Of Transport NMDA Selective Glutamate Receptor Complex Calcium Ion Transport Trans-synaptic Signaling Postsynaptic Density Membrane Synaptic Signaling Ionotropic Glutamate Receptor Signaling Pathway Plasma Membrane Protein Kinase CK2 Complex Glycine-gated Cation Channel Activity Protein Kinase Activity Regulation Of Synaptic Plasticity Ligand-gated Ion Channel Signaling Pathway Regulation Of Membrane Potential Neuron Projection Metal Ion Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Kinase Activity Receptor Clustering Regulation Of Protein Localization To Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Phosphate-containing Compound Metabolic Process Regulation Of Cellular Localization Regulation Of Biological Quality Protein Localization To Synapse Protein Serine/threonine Kinase Activity Regulation Of Protein Localization To Plasma Membrane Regulation Of Synapse Organization NMDA Glutamate Receptor Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Monoatomic Cation Transport Transmembrane Transporter Binding Cell-cell Signaling GMP Kinase Activity Protein Phosphorylation Regulation Of Signaling Neuromuscular Junction Regulation Of Cell Communication	Dendritic Spine Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Trans-synaptic Protein Complex AMPA Glutamate Receptor Activity Synaptic Signaling Via Neuropeptide Forebrain Morphogenesis Chemical Synaptic Transmission Trans-synaptic Signaling Regulation Of Postsynaptic Membrane Potential Postsynaptic Density Membrane Synaptic Signaling Prepulse Inhibition Startle Response Synapse Regulation Of Membrane Potential Monoatomic Ion Channel Activity Dentate Gyrus Development AMPA Glutamate Receptor Complex Glutamatergic Synapse Positive Regulation Of Excitatory Postsynaptic Potential Cell-cell Signaling Signaling Postsynaptic Membrane Cell Communication Synapse Organization Modulation Of Excitatory Postsynaptic Potential Signaling Receptor Activity Learning Or Memory Social Behavior Visual Learning Regulation Of Synapse Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Excitatory Postsynaptic Potential Visual Behavior Cognition Negative Regulation Of Synaptic Vesicle Clustering Sperm Entry Positive Regulation Of Golgi Lumen Acidification Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels PDZ Domain Binding Futile Creatine Cycle Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration
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