GRIN2A and CAMK2B

Number of citations of the paper that reports this interaction (PMID 12147342)
7

Data Source:
HPRD (in vivo, in vitro)

		GRIN2A	CAMK2B
Gene Name		glutamate receptor, ionotropic, N-methyl D-aspartate 2A	calcium/calmodulin-dependent protein kinase II beta
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Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Presynaptic Membrane Postsynaptic Membrane Neuronal Postsynaptic Density	Nucleoplasm Microtubule Organizing Center Cytosol Plasma Membrane Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Spindle Midzone
	Molecular Function	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Protein Binding Zinc Ion Binding	Actin Binding Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Protein Homodimerization Activity
	Biological Process	Startle Response Response To Amphetamine Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Learning Or Memory Memory Protein Localization Visual Learning Response To Wounding Sensory Perception Of Pain Neurogenesis Sleep Directional Locomotion Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Negative Regulation Of Protein Catabolic Process Dopamine Metabolic Process Serotonin Metabolic Process Response To Drug Positive Regulation Of Apoptotic Process Response To Ethanol Regulation Of Synaptic Plasticity Regulation Of Sensory Perception Of Pain Regulation Of Excitatory Postsynaptic Membrane Potential Calcium Ion Transmembrane Transport	G1/S Transition Of Mitotic Cell Cycle Inhibitory G-protein Coupled Receptor Phosphorylation Protein Phosphorylation Calcium Ion Transport Signal Transduction Synaptic Transmission Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Peptidyl-serine Phosphorylation Cytokine-mediated Signaling Pathway Regulation Of Synaptic Transmission, Cholinergic Cellular Response To Heat Response To Cadmium Ion Protein Autophosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Neuromuscular Process Controlling Balance Regulation Of Synapse Structural Plasticity Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Activation Of Meiosis Involved In Egg Activation Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Regulation Of Cellular Response To Heat Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses	Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors Interferon gamma signaling HSF1-dependent transactivation Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Glycine Meperidine Felbamate Memantine Halothane Tenocyclidine
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Hepatitis B ( 22004137) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Metabolic syndrome ( 22399527)
Protein-Protein Interactions		27 interactors: ACTN1 AP1M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CASK CDK5 DLG1 DLG2 DLG3 DLG4 DLGAP1 FYN GRIN1 GRIN3A GRIN3B IL16 INADL NEDD4 PLCG1 PRKCA PTK2B PTPN4 RGS3 SPTAN1 SRC	37 interactors: ACOT7 ACTN4 AP5B1 ATXN1 CAMK2D CAMK2N2 CCM2L COL4A3 ETS1 FAM171A2 GAPDH GRIN2A GRIN2B ITPKA KRTAP10-11 KRTAP19-5 KRTAP19-7 MAD2L2 MED18 MGAT5B MORF4L1 MRPL11 MVP PHKB PLCB3 POP5 RAP2B RBFOX2 RBPMS RPL11 RXRG SEMA4G SMYD3 SPRYD7 THRB TTC5 YWHAB
Entrez ID		2903	816
HPRD ID		00698	12127
Ensembl ID		ENSG00000183454	ENSG00000058404
Uniprot IDs		B4DII7 F5GZ52 Q12879 Q547U9 Q59EW6	A4D2J9 Q13554
PDB IDs		3NFL	3BHH
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Protein Localization To Synapse Chemotaxis Neuron Projection Development Receptor Localization To Synapse Neuron Development Locomotion Axon Guidance Regulation Of Ion Transport Neuron Differentiation Cell Projection Organization Response To External Stimulus Protein Autophosphorylation Receptor Clustering Generation Of Neurons Axonogenesis Nucleotide Phosphorylation Neurogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Membrane Organization Neuron Projection Morphogenesis Movement Of Cell Or Subcellular Component Regulation Of Synaptic Plasticity Nervous System Development Cell Morphogenesis Involved In Differentiation Regulation Of Calcium Ion Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-cell Junction Organization Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Cell Projection Morphogenesis Cell Development Peptidyl-serine Phosphorylation Cell Part Morphogenesis Phosphorylation Signaling Regulation Of Neuronal Synaptic Plasticity Regulation Of Membrane Potential Cell Communication Cell Activation Phosphate-containing Compound Metabolic Process Glutamate Receptor Signaling Pathway Cell Differentiation Response To Stimulus Immune Response Regulation Of Cell Projection Organization Regulation Of Synaptic Transmission Epidermal Growth Factor Receptor Signaling Pathway	Negative Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Excitatory Postsynaptic Membrane Potential Intracellular Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Postsynaptic Membrane Potential Regulation Of Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stimulus Regulation Of Protein Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Membrane Depolarization Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transferase Activity Startle Response Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Retinoic Acid Receptor Signaling Pathway Neuromuscular Process Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Protein Autophosphorylation Positive Regulation Of Phosphorylation Regulation Of RNA Metabolic Process Learning Positive Regulation Of Metabolic Process Response To Stress Gene Expression Synaptic Transmission Cardiac Muscle Tissue Growth Regulation Of Erythrocyte Differentiation Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Palmitic Acid Biosynthetic Process Peptidyl-cysteine S-trans-nitrosylation Medium-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty-acyl-CoA Catabolic Process System Development Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Cellular Response To Steroid Hormone Stimulus Sensory Perception Of Mechanical Stimulus Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation
Tagcloud ?		6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta	1alpha apoptosis apoptotic bcl2 calmodulin enos ep300 epo explore expressions hhcy hif homocysteine hyperhomocysteinemia involvement itraq lower methoxyestradiol mtt neurons overexpression percentage presumed protects suppressed technique transfection tried
Tagcloud (Difference) ?		6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta	1alpha apoptosis apoptotic bcl2 calmodulin enos ep300 epo explore expressions hhcy hif homocysteine hyperhomocysteinemia involvement itraq lower methoxyestradiol mtt neurons overexpression percentage presumed protects suppressed technique transfection tried
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