GRIN2A and CDK5

Number of citations of the paper that reports this interaction (PubMedID 11675505)
52

Data Source:
HPRD (in vitro)

		GRIN2A	CDK5
Description		glutamate ionotropic receptor NMDA type subunit 2A	cyclin dependent kinase 5
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane Synaptic Membrane Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Lamellipodium Cell Junction Filopodium Axon Dendrite Growth Cone Neuromuscular Junction Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Synapse Presynapse
	Molecular Function	Amyloid-beta Binding NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Zinc Ion Binding Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Metal Ion Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ErbB-2 Class Receptor Binding Protein Binding ATP Binding Microtubule Binding Kinase Activity Transferase Activity Signaling Receptor Inhibitor Activity Acetylcholine Receptor Activator Activity Ionotropic Glutamate Receptor Binding ErbB-3 Class Receptor Binding Tau Protein Binding Tau-protein Kinase Activity Hsp90 Protein Binding Protein Serine Kinase Activity
	Biological Process	Startle Response Response To Amphetamine Monoatomic Ion Transport Calcium Ion Transport Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Brain Development Learning Or Memory Learning Memory Visual Learning Response To Xenobiotic Stimulus Response To Wounding Sensory Perception Of Pain Calcium-mediated Signaling Neurogenesis Protein Catabolic Process Sleep Directional Locomotion Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Sodium Ion Transmembrane Transport Locomotion Negative Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Dopamine Metabolic Process Serotonin Metabolic Process Positive Regulation Of Apoptotic Process Response To Ethanol Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Protein Localization To Postsynaptic Membrane Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Amyloid-beta Positive Regulation Of Excitatory Postsynaptic Potential	Microtubule Cytoskeleton Organization Neuron Migration Synaptic Transmission, Dopaminergic Intracellular Protein Transport Apoptotic Process Cell-matrix Adhesion Chemical Synaptic Transmission Nervous System Development Axonogenesis Synapse Assembly Skeletal Muscle Tissue Development Motor Neuron Axon Guidance Associative Learning Visual Learning Schwann Cell Development Synaptic Vesicle Exocytosis Regulation Of Macroautophagy Cell Migration Sensory Perception Of Pain Telencephalon Development Cerebellum Development Cerebellar Cortex Development Cerebellar Cortex Formation Hippocampus Development Layer Formation In Cerebral Cortex Central Nervous System Neuron Development Cerebral Cortex Development Corpus Callosum Development Actin Cytoskeleton Organization Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Axon Extension Forebrain Development Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Synaptic Plasticity Receptor Catabolic Process Synaptic Transmission, Glutamatergic Protein Localization To Synapse Response To Cocaine Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Protein Export From Nucleus Behavioral Response To Cocaine Regulation Of Synaptic Plasticity Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Rhythmic Process Axon Extension Oligodendrocyte Differentiation Dendrite Morphogenesis Cell Division Neuron Apoptotic Process Establishment Of Localization In Cell Regulation Of Cell Cycle Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Regulation Of Dendritic Spine Morphogenesis Calcium Ion Import Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Regulation Of Cell Cycle Phase Transition Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Synaptic Vesicle Recycling Cellular Response To Amyloid-beta
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Neurexins and neuroligins Synaptic adhesion-like molecules MECP2 regulates neuronal receptors and channels Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	DARPP-32 events CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription Activated NTRK2 signals through CDK5 NPAS4 regulates expression of target genes Factors involved in megakaryocyte development and platelet production MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs		Glutamic acid Glycine Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Dextropropoxyphene Acamprosate Donepezil Guaifenesin Felbamate Memantine Halothane Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)	Indirubin-3'-monoxime Olomoucine Hymenialdisine SU9516 Alvocidib Alsterpaullone 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE Trilaciclib
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bevacizumab-induced composite toxicity (either hypertension or proteinuria) ( 34616010) Bipolar disorder ( 33263727 31043756 34002096) Bipolar I disorder ( 31043756) Chronic kidney disease ( 26420894) Clostridioides difficle infection ( 33841421) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Copper levels ( 26025379) Daytime nap ( 33568662) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Hallux valgus ( 32131869) Hepatitis B ( 22004137) Laryngeal squamous cell carcinoma ( 25194280) Lung function (FVC) ( 30804560) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260 29483656 28991256 25056061) Tenofovir clearance in HIV infection ( 26148204) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist circumference adjusted for BMI (smoking interaction) ( 28443625)	Age at first sexual intercourse ( 34211149) Eyebrow thickness ( 26926045) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		32 interacting genes: ACTN1 AKT1 AP1M1 AP2M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CASK CDK5 CSNK2A1 CSNK2A2 CSNK2B DLG1 DLG2 DLG3 DLG4 DLGAP1 FYN GRIN1 GRIN3A GRIN3B IL16 NEDD4 PATJ PLCG1 PRKCA PTK2B PTPN4 RGS3 SPTAN1 SRC	78 interacting genes: AATK ABL1 ACTN1 ALAS1 AMPH APP BAG6 CABLES1 CABLES2 CCND2 CCND3 CCNG1 CDC25A CDC25B CDC25C CDC37 CDK16 CDK5R1 CDK5R2 CDK5RAP1 CDK5RAP2 CDKN1B CHN1 CSNK1D DAB1 DCX DNM1 ERBB3 EZR FSD1 FYN FZR1 GAK GRIN2A GSK3B H1-0 H1-1 H1-5 HTRA2 KIF26B LMTK2 MAP2K1 MAPK10 MAPT MAST1 MBP MEF2A MEOX2 MIR9-1HG NDEL1 NEDD4 NEDD4L NES PAK1 PCNA PIKFYVE PIP5K1C PPARG PPP1R1B PPP1R2 PSEN1 PTPN2 PURA RB1 RNF32 RPL34 SET SPDYA SRC STX1A STXBP1 SYN1 SYNJ1 TLN1 TP53 TRIM59 WASF1 YBX3
Entrez ID		2903	1020
HPRD ID		00698	00449
Ensembl ID		ENSG00000183454	ENSG00000164885
Uniprot IDs		A0A890YTL4 Q12879 Q547U9 Q59EW6	A0A090N7W4 A0A0S2Z355 Q00535
PDB IDs		3NFL 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA 6IRA 6IRF 6IRG 6IRH 7EOQ 7EOR 7EOS 7EOT 7EOU 7EU7 8E99 8JIZ 8JJ0 8JJ1 8JJ2 8VUH 8VUJ 8VUL 8VUN 8VUQ 8VUR 8VUT	1H4L 1UNG 1UNH 1UNL 3O0G 4AU8 7VDP 7VDQ 7VDR 7VDS
Enriched GO Terms of Interacting Partners?		Ionotropic Glutamate Receptor Binding Postsynaptic Density Regulation Of Metal Ion Transport Synapse Regulation Of Monoatomic Ion Transport Cytosol Cell Junction Modulation Of Chemical Synaptic Transmission Regulation Of Calcium Ion Transport Chemical Synaptic Transmission Glutamate Receptor Signaling Pathway Glutamatergic Synapse Regulation Of Transport NMDA Selective Glutamate Receptor Complex Calcium Ion Transport Trans-synaptic Signaling Postsynaptic Density Membrane Synaptic Signaling Ionotropic Glutamate Receptor Signaling Pathway Plasma Membrane Protein Kinase CK2 Complex Glycine-gated Cation Channel Activity Protein Kinase Activity Regulation Of Synaptic Plasticity Ligand-gated Ion Channel Signaling Pathway Regulation Of Membrane Potential Neuron Projection Metal Ion Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Kinase Activity Receptor Clustering Regulation Of Protein Localization To Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Phosphate-containing Compound Metabolic Process Regulation Of Cellular Localization Regulation Of Biological Quality Protein Localization To Synapse Protein Serine/threonine Kinase Activity Regulation Of Protein Localization To Plasma Membrane Regulation Of Synapse Organization NMDA Glutamate Receptor Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Monoatomic Cation Transport Transmembrane Transporter Binding Cell-cell Signaling GMP Kinase Activity Protein Phosphorylation Regulation Of Signaling Neuromuscular Junction Regulation Of Cell Communication	Protein Kinase Binding Cytosol Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Developmental Process Regulation Of Protein Modification Process Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Regulation Of Cellular Component Organization Regulation Of Neuron Apoptotic Process Cell Cycle Phase Transition Regulation Of Protein Serine/threonine Kinase Activity Organelle Organization Perinuclear Region Of Cytoplasm Regulation Of Protein Kinase Activity Cytoplasm Cyclin-dependent Protein Kinase Holoenzyme Complex Neuron Apoptotic Process Regulation Of Organelle Organization Regulation Of Kinase Activity Kinase Activity Cell Projection Organization G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Phosphorus Metabolic Process Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Cellular Developmental Process Regulation Of Apoptotic Process Endocytosis Layer Formation In Cerebral Cortex Regulation Of Protein Phosphorylation Organelle Localization Positive Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Regulation Of Mitotic Cell Cycle Regulation Of Protein-containing Complex Assembly Positive Regulation Of Organelle Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Negative Regulation Of Programmed Cell Death
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