CAMK2G and STMN1

Number of citations of the paper that reports this interaction (PubMedID 28319085)
75

Data Source:
BioGRID (enzymatic study, genetic interference)

		CAMK2G	STMN1
Description		calcium/calmodulin dependent protein kinase II gamma	stathmin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection	Cytoplasm Cytosol Cytoskeleton Microtubule Membrane Neuron Projection Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity	Protein Binding Tubulin Binding
	Biological Process	Nervous System Development Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Insulin Secretion Cell Differentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Regulation Of Protein Localization To Plasma Membrane	Mitotic Cytokinesis Microtubule Depolymerization Mitotic Spindle Organization Signal Transduction Nervous System Development Axonogenesis Response To Virus Cell Differentiation Regulation Of Cell Migration Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Stress Fiber Assembly Establishment Of Skin Barrier Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity
Pathways		CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Nuclear signaling by ERBB4
Drugs		Bosutinib 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Fostamatinib
Diseases
GWAS		Body size at age 10 ( 32376654) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908) FEV1 ( 30804560) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560) Psoriasis ( 25939698) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458)
Interacting Genes		51 interacting genes: ACTN2 ACTN4 ADCY3 ATF1 CABP2 CALM1 CDC37 CEBPA CHAT CREM DUS1L EGFR ESRRG FLNA FXR1 FXR2 GRIA1 GRIA4 GRIN1 GRIN2B KANK2 KRTAP19-3 KRTAP6-1 KRTAP6-3 LRRC7 MAP3K7 MRPL11 MYLK NUTF2 NXF1 PEA15 PLCB3 PSMB1 PTEN RCHY1 RRAD RYR1 SMAD2 SMAD3 SMAD4 SPR STAT1 STMN1 STRBP SYN1 TH TIAM1 TNPO2 TNPO3 TTC5 UBE2I	21 interacting genes: CAMK2G CDK1 CDKN1B CEBPA CHEK2 CSNK2A1 ERBB2 FANCC GLP1R HSPA5 HSPA8 HUNK LINC00632 MAPK3 PRKACA PRKCA SEPTIN2 SESTD1 STAT3 UBQLN4 UHMK1
Entrez ID		818	3925
HPRD ID		03672	01047
Ensembl ID		ENSG00000148660	ENSG00000117632
Uniprot IDs		A0A2Q3DQE3 B3KY86 H0Y6G2 Q13280 Q13555 Q5SWX3	A0A140VJW2 P16949
PDB IDs		2UX0 2V7O
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Intracellular Signal Transduction Cytoplasm Synapse Cytosol Neuron Projection SMAD Protein Complex Identical Protein Binding Learning Or Memory Modulation Of Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Ionotropic Glutamate Receptor Signaling Pathway Heteromeric SMAD Protein Complex Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Monoatomic Ion Channel Activity Cognition Chemical Synaptic Transmission Regulation Of Membrane Potential Dendritic Spine Signal Transduction Trans-synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Calcium Ion Transmembrane Import Into Cytosol Synaptic Signaling Positive Regulation Of Signal Transduction Positive Regulation Of RNA Metabolic Process Kinase Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Modulation Of Excitatory Postsynaptic Potential I-SMAD Binding Postsynaptic Density Membrane Glutamate Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Monoatomic Ion Transmembrane Transport Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Calmodulin Binding Regulation Of Neuronal Synaptic Plasticity Nuclear Import Signal Receptor Activity Regulation Of Monoatomic Ion Transport Regulation Of Synaptic Plasticity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Communication Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Signaling Pathway Cell Development Positive Regulation Of Signaling Ameboidal-type Cell Migration	Protein Serine Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Phosphorylation Nucleotide Binding ATP Binding Nucleoplasm Protein Phosphorylation Regulation Of Protein Catabolic Process Intracellular Signal Transduction Response To Stress Regulation Of Protein Metabolic Process Cellular Response To Stress Signal Transduction In Response To DNA Damage Regulation Of Cellular Component Organization Phosphate-containing Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Macroautophagy Regulation Of Proteasomal Protein Catabolic Process Regulation Of Autophagy Intracellular Signaling Cassette Regulation Of Transport Regulation Of Protein Localization Transferase Activity Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Nutrient Levels Intracellular Protein Localization Ubiquitin Protein Ligase Binding Regulation Of Cellular Localization DNA Damage Response Regulation Of Establishment Of Protein Localization Regulation Of Cellular Response To Stress Post-translational Protein Targeting To Membrane, Translocation Intracellular Protein Transport Positive Regulation Of Catabolic Process ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Nucleic Acid Metabolic Process Mitotic Nuclear Membrane Disassembly Cellular Response To Glucagon Stimulus Positive Regulation Of Cell Population Proliferation Regulation Of Proteolysis Response To Hormone Protein Catabolic Process Negative Regulation Of Catabolic Process Interleukin-2-mediated Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?