CAMK2G and NUTF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CAMK2G	NUTF2
Description		calcium/calmodulin dependent protein kinase II gamma	nuclear transport factor 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection	Nucleus Nuclear Inner Membrane Nuclear Outer Membrane Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Membrane Nuclear Pore Central Transport Channel Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity	Protein Binding Structural Constituent Of Nuclear Pore Small GTPase Binding Identical Protein Binding Nuclear Import Signal Receptor Activity
	Biological Process	Nervous System Development Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Insulin Secretion Cell Differentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Regulation Of Protein Localization To Plasma Membrane	Protein Import Into Nucleus Protein Export From Nucleus Nucleocytoplasmic Transport Protein Transport MRNA Transport Protein Localization To Nuclear Pore
Pathways		CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		Bosutinib 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Fostamatinib
Diseases
GWAS		Body size at age 10 ( 32376654) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908) FEV1 ( 30804560) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560) Psoriasis ( 25939698) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458)	Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		51 interacting genes: ACTN2 ACTN4 ADCY3 ATF1 CABP2 CALM1 CDC37 CEBPA CHAT CREM DUS1L EGFR ESRRG FLNA FXR1 FXR2 GRIA1 GRIA4 GRIN1 GRIN2B KANK2 KRTAP19-3 KRTAP6-1 KRTAP6-3 LRRC7 MAP3K7 MRPL11 MYLK NUTF2 NXF1 PEA15 PLCB3 PSMB1 PTEN RCHY1 RRAD RYR1 SMAD2 SMAD3 SMAD4 SPR STAT1 STMN1 STRBP SYN1 TH TIAM1 TNPO2 TNPO3 TTC5 UBE2I	48 interacting genes: BEND7 BRWD1 CAMK2G CCDC106 CCDC150 CCDC158 CEBPA CHCHD3 CHMP4A CKMT1A CKMT1B CLPP FAM50B HMG20A HMG20B KHDC4 KRT86 KRTAP9-8 LASP1 LCE1C LCE5A LENG1 LUC7L2 MRNIP MYOZ3 NME1 NME4 NRIP3 NUP54 NUP62 PAX4 PBX4 PCNA PFKP PHF11 PPP1R16A PTMA RAN RPRD1B SPATC1L SPRY4 TEX35 THAP11 THAP3 TLE5 UBAP2 YAF2 ZMAT2
Entrez ID		818	10204
HPRD ID		03672	12050
Ensembl ID		ENSG00000148660	ENSG00000102898
Uniprot IDs		A0A2Q3DQE3 B3KY86 H0Y6G2 Q13280 Q13555 Q5SWX3	P61970
PDB IDs		2UX0 2V7O	1GY5
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Intracellular Signal Transduction Cytoplasm Synapse Cytosol Neuron Projection SMAD Protein Complex Identical Protein Binding Learning Or Memory Modulation Of Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Ionotropic Glutamate Receptor Signaling Pathway Heteromeric SMAD Protein Complex Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Monoatomic Ion Channel Activity Cognition Chemical Synaptic Transmission Regulation Of Membrane Potential Dendritic Spine Signal Transduction Trans-synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Calcium Ion Transmembrane Import Into Cytosol Synaptic Signaling Positive Regulation Of Signal Transduction Positive Regulation Of RNA Metabolic Process Kinase Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Modulation Of Excitatory Postsynaptic Potential I-SMAD Binding Postsynaptic Density Membrane Glutamate Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Monoatomic Ion Transmembrane Transport Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Calmodulin Binding Regulation Of Neuronal Synaptic Plasticity Nuclear Import Signal Receptor Activity Regulation Of Monoatomic Ion Transport Regulation Of Synaptic Plasticity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Communication Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Signaling Pathway Cell Development Positive Regulation Of Signaling Ameboidal-type Cell Migration	Protein Binding Protein-containing Complex Binding Phosphocreatine Biosynthetic Process Creatine Kinase Activity GTP Metabolic Process Nuclear Pore Nuclear Pore Central Transport Channel Nucleus UTP Biosynthetic Process GTP Biosynthetic Process UTP Metabolic Process Nucleoplasm Protein Hexamerization Negative Regulation Of Protein Sumoylation Male Germ Cell Nucleus CTP Biosynthetic Process CTP Metabolic Process
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