CAMK2G and CHAT

Number of citations of the paper that reports this interaction (PubMedID 12486117)
0

Data Source:
HPRD (in vivo, in vitro)

		CAMK2G	CHAT
Description		calcium/calmodulin dependent protein kinase II gamma	choline O-acetyltransferase
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection	Nucleus Cytoplasm Cytosol Neuron Projection Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity	Choline O-acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity
	Biological Process	Nervous System Development Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Insulin Secretion Cell Differentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Regulation Of Protein Localization To Plasma Membrane	Phosphatidylcholine Biosynthetic Process Neurotransmitter Transport Neuromuscular Synaptic Transmission Acetylcholine Biosynthetic Process
Pathways		CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Synthesis of PC Acetylcholine Neurotransmitter Release Cycle
Drugs		Bosutinib 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Fostamatinib	Nicotine
Diseases			Congenital myasthenic syndrome
GWAS		Body size at age 10 ( 32376654) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908) FEV1 ( 30804560) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560) Psoriasis ( 25939698) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458)	Glaucoma (primary angle closure) ( 27064256) Interleukin-1-receptor antagonist levels ( 22205395) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Type 2 diabetes nephropathy ( 30566433)
Interacting Genes		51 interacting genes: ACTN2 ACTN4 ADCY3 ATF1 CABP2 CALM1 CDC37 CEBPA CHAT CREM DUS1L EGFR ESRRG FLNA FXR1 FXR2 GRIA1 GRIA4 GRIN1 GRIN2B KANK2 KRTAP19-3 KRTAP6-1 KRTAP6-3 LRRC7 MAP3K7 MRPL11 MYLK NUTF2 NXF1 PEA15 PLCB3 PSMB1 PTEN RCHY1 RRAD RYR1 SMAD2 SMAD3 SMAD4 SPR STAT1 STMN1 STRBP SYN1 TH TIAM1 TNPO2 TNPO3 TTC5 UBE2I	9 interacting genes: CAMK2A CAMK2G NEDD9 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ
Entrez ID		818	1103
HPRD ID		03672	07510
Ensembl ID		ENSG00000148660	ENSG00000070748
Uniprot IDs		A0A2Q3DQE3 B3KY86 H0Y6G2 Q13280 Q13555 Q5SWX3	P28329 Q6LEN5 Q6LEN6
PDB IDs		2UX0 2V7O	2FY2 2FY3 2FY4 2FY5 7AMD
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Intracellular Signal Transduction Cytoplasm Synapse Cytosol Neuron Projection SMAD Protein Complex Identical Protein Binding Learning Or Memory Modulation Of Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Ionotropic Glutamate Receptor Signaling Pathway Heteromeric SMAD Protein Complex Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Monoatomic Ion Channel Activity Cognition Chemical Synaptic Transmission Regulation Of Membrane Potential Dendritic Spine Signal Transduction Trans-synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Calcium Ion Transmembrane Import Into Cytosol Synaptic Signaling Positive Regulation Of Signal Transduction Positive Regulation Of RNA Metabolic Process Kinase Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Modulation Of Excitatory Postsynaptic Potential I-SMAD Binding Postsynaptic Density Membrane Glutamate Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Monoatomic Ion Transmembrane Transport Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Calmodulin Binding Regulation Of Neuronal Synaptic Plasticity Nuclear Import Signal Receptor Activity Regulation Of Monoatomic Ion Transport Regulation Of Synaptic Plasticity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Communication Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Signaling Pathway Cell Development Positive Regulation Of Signaling Ameboidal-type Cell Migration	Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Protein Phosphorylation Long-term Synaptic Potentiation Phosphorylation Regulation Of Synaptic Plasticity ATP Binding Regulation Of Protein Localization Histone H3T6 Kinase Activity Nucleotide Binding Regulation Of Biological Quality Transferase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Positive Regulation Of Protein Localization Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Cell Communication Regulation Of Signaling Regulation Of Transport Positive Regulation Of Immune System Process Regulation Of Secretion By Cell Positive Regulation Of Protein Transport Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Regulation Of Secretion Response To Hormone Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Neurotransmitter Secretion Positive Regulation Of Insulin Secretion Mitotic Nuclear Membrane Disassembly Response To Peptide Hormone Positive Regulation Of Establishment Of Protein Localization Insulin Receptor Substrate Binding Positive Regulation Of Peptide Hormone Secretion Nuclear Membrane Disassembly Positive Regulation Of Peptide Secretion Membrane Disassembly Phosphate-containing Compound Metabolic Process Regulation Of Protein Localization To Plasma Membrane Response To Morphine
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?