EDNRA and KAT5

Number of citations of the paper that reports this interaction (PMID 11262386)
12

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		EDNRA	KAT5
Gene Name		endothelin receptor type A	K(lysine) acetyltransferase 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane T-tubule Nuclear Membrane Membrane Raft	Swr1 Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Piccolo NuA4 Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Endothelin Receptor Activity Protein Binding	Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Protein Complex Binding Metal Ion Binding Androgen Receptor Binding Repressing Transcription Factor Binding
	Biological Process	Patterning Of Blood Vessels Response To Hypoxia In Utero Embryonic Development Histamine Secretion Positive Regulation Of Protein Phosphorylation Glomerular Filtration Smooth Muscle Contraction Signal Transduction G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Heart Development Aging Respiratory Gaseous Exchange Metabolic Process Regulation Of Blood Pressure Cell Proliferation Positive Regulation Of Cell Proliferation Neural Crest Cell Development Artery Smooth Muscle Contraction Glucose Transport Sensory Perception Of Pain Negative Regulation Of CAMP Biosynthetic Process Response To Lipopolysaccharide Vasoconstriction Positive Regulation Of Odontogenesis Negative Regulation Of Apoptotic Process Penile Erection Response To Morphine Fibroblast Proliferation Enteric Nervous System Development Smooth Muscle Cell Proliferation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Maternal Process Involved In Parturition Head Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Endothelin Receptor Signaling Pathway Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Kidney Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Double-strand Break Repair Chromatin Organization Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Ionizing Radiation Viral Process Histone Acetylation Androgen Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Regulation Of Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Estradiol Stimulus Positive Regulation Of Protein Acetylation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Chromatin modifying enzymes Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer HATs acetylate histones
Drugs		Bosentan 2-HYDROXY-3,5-DIIODOBENZOIC ACID Sitaxentan
Diseases
GWAS		Carotid intima media thickness ( 21909108) Dental caries ( 23064961) Intracranial aneurysm ( 22286173) Obesity-related traits ( 23251661)	Chronic kidney disease ( 20383146)
Protein-Protein Interactions		7 interactors: EDN1 EDN3 GNA11 GNAI2 GRK6 HDAC7 KAT5	136 interactors: ALOX12 APBB1 APLP1 APLP2 APP AR ARIH2 ATM ATXN1 BARD1 BCL3 BMI1 BRCA1 C1orf174 CBX8 CCDC106 CCDC136 CCNB1 CCT7 CDC42 CDK1 CDK5RAP2 CDKN2A CREB1 CREBBP CRELD1 CSTF2 DLEU1 DUSP23 E2F1 EDNRA EFNA1 EP300 ESR1 ESR2 ETV6 FAM101B FAM135B FAM173A GADD45G GAPDH GEMIN7 GET4 GMCL1 GMCL1P1 GOLGA2 GSTO1 H2AFX H3F3B HABP4 HAP1 HDAC1 HDAC7 HIST1H3A HIST1H4A HIST2H2AC HIST2H3C HIST2H4A HIST3H3 HMBOX1 HNRNPH3 IK IKZF3 IL9R KIAA1377 KLF4 KRT40 KRTAP10-3 KRTAP10-9 LMNA LONRF1 LRIF1 LRP1 LZTS2 MAD2L1BP MAPRE1 MDFI MDM2 MEOX2 MTUS2 MYC MYOD1 NAP1L5 NDUFA4L2 NDUFV2 NFKB1 NINL NR3C1 ODC1 OGFOD2 PDCD5 PHC2 PIH1D3 PITX2 PLA2G4A PLEKHA4 PML POLE2 POLR3F PPARG PTPN4 PTPRS RB1 RCHY1 RELA RGL2 RRM1 RRM2 SAT1 SNAPIN SNRPD2 SOX5 SRF SSX2IP STAT3 STX11 SYN1 TBX5 TELO2 TMCC2 TNNT1 TP53 TRIB3 TRIM23 TRIM27 TRIM29 TRIM37 TUFT1 UHRF1 USP7 YWHAG ZBTB14 ZBTB8A ZEB1 ZNF24 ZNF513
Entrez ID		1909	10524
HPRD ID		00571	03245
Ensembl ID		ENSG00000151617	ENSG00000172977
Uniprot IDs		P25101	Q92993
PDB IDs			2EKO 2OU2
Enriched GO Terms of Interacting Partners?		Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Vascular Smooth Muscle Contraction Inositol Phosphate-mediated Signaling Negative Regulation Of Interleukin-2 Production Positive Regulation Of Heart Rate Regulation Of Developmental Pigmentation Cell Activation Signal Transduction Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Heart Contraction Cell Surface Receptor Signaling Pathway Negative Regulation Of CAMP Metabolic Process Vasoconstriction Signaling Cell Communication Negative Regulation Of Nucleotide Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Protein Modification Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Endothelial Cell Migration Regulation Of Vasoconstriction Smooth Muscle Contraction Cellular Response To Stimulus Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Developmental Pigmentation Peptide Hormone Secretion Neural Crest Cell Development Positive Regulation Of Leukocyte Chemotaxis Peptide Secretion Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Heart Rate Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Neural Crest Cell Differentiation Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Protein Kinase Activity Hormone Secretion Positive Regulation Of Leukocyte Migration Regulation Of CAMP Biosynthetic Process Positive Regulation Of Kinase Activity Phospholipase D-activating G-protein Coupled Receptor Signaling Pathway Protein Kinase C Deactivation Negative Regulation Of Biosynthetic Process Hormone Transport	Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Transcription, DNA-templated Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Organ Development Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Chromatin Organization Positive Regulation Of Metabolic Process Mitotic Cell Cycle Chromosome Organization Anatomical Structure Development Cellular Macromolecule Biosynthetic Process System Development Tissue Development Cell Cycle Macromolecule Biosynthetic Process Regulation Of Cell Proliferation Cell Death Apoptotic Process Death Organelle Organization Programmed Cell Death Biosynthetic Process
Tagcloud ?		aacr acquire arr1 arrb1 arrestin chemoresistance chemoresistant cisplatinum edn1 emt endothelin eoc et etar etbr impairing intravasation links macitentan overcome paucity pharmacologic potentiation rationale reorganization res sustain sustains vascularization	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Difference) ?		aacr acquire arr1 arrb1 arrestin chemoresistance chemoresistant cisplatinum edn1 emt endothelin eoc et etar etbr impairing intravasation links macitentan overcome paucity pharmacologic potentiation rationale reorganization res sustain sustains vascularization	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Intersection) ?