EDNRA and EDN3

Number of citations of the paper that reports this interaction (PMID 11982704)
0

Data Source:
HPRD (in vitro, in vivo)

		EDNRA	EDN3
Gene Name		endothelin receptor type A	endothelin 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane T-tubule Nuclear Membrane Membrane Raft	Extracellular Region Extracellular Space
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Endothelin Receptor Activity Protein Binding	Receptor Binding Hormone Activity
	Biological Process	Patterning Of Blood Vessels Response To Hypoxia In Utero Embryonic Development Histamine Secretion Positive Regulation Of Protein Phosphorylation Glomerular Filtration Smooth Muscle Contraction Signal Transduction G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Heart Development Aging Respiratory Gaseous Exchange Metabolic Process Regulation Of Blood Pressure Cell Proliferation Positive Regulation Of Cell Proliferation Neural Crest Cell Development Artery Smooth Muscle Contraction Glucose Transport Sensory Perception Of Pain Negative Regulation Of CAMP Biosynthetic Process Response To Lipopolysaccharide Vasoconstriction Positive Regulation Of Odontogenesis Negative Regulation Of Apoptotic Process Penile Erection Response To Morphine Fibroblast Proliferation Enteric Nervous System Development Smooth Muscle Cell Proliferation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Maternal Process Involved In Parturition Head Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Endothelin Receptor Signaling Pathway Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Kidney Development	Neural Crest Cell Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Endothelin Cellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Multicellular Organismal Development Blood Circulation Positive Regulation Of Cell Proliferation Positive Regulation Of Heart Rate Cellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Peptide Hormone Secretion Neuron Differentiation Melanocyte Differentiation Neutrophil Chemotaxis Vasoconstriction Positive Regulation Of MAP Kinase Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Hormone Secretion Inositol Phosphate-mediated Signaling Regulation Of Developmental Pigmentation Positive Regulation Of Potassium Ion Transmembrane Transport
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Bosentan 2-HYDROXY-3,5-DIIODOBENZOIC ACID Sitaxentan
Diseases
GWAS		Carotid intima media thickness ( 21909108) Dental caries ( 23064961) Intracranial aneurysm ( 22286173) Obesity-related traits ( 23251661)	Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) Hypertension ( 19430479 21909115) Response to diuretic therapy in hypertension ( 23753411) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		7 interactors: EDN1 EDN3 GNA11 GNAI2 GRK6 HDAC7 KAT5	5 interactors: CMA1 CTSE EDNRA EDNRB KEL
Entrez ID		1909	1908
HPRD ID		00571	00570
Ensembl ID		ENSG00000151617	ENSG00000124205
Uniprot IDs		P25101	P14138 Q4FAT2
PDB IDs
Enriched GO Terms of Interacting Partners?		Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Vascular Smooth Muscle Contraction Inositol Phosphate-mediated Signaling Negative Regulation Of Interleukin-2 Production Positive Regulation Of Heart Rate Regulation Of Developmental Pigmentation Cell Activation Signal Transduction Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Heart Contraction Cell Surface Receptor Signaling Pathway Negative Regulation Of CAMP Metabolic Process Vasoconstriction Signaling Cell Communication Negative Regulation Of Nucleotide Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Protein Modification Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Endothelial Cell Migration Regulation Of Vasoconstriction Smooth Muscle Contraction Cellular Response To Stimulus Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Developmental Pigmentation Peptide Hormone Secretion Neural Crest Cell Development Positive Regulation Of Leukocyte Chemotaxis Peptide Secretion Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Heart Rate Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Neural Crest Cell Differentiation Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Protein Kinase Activity Hormone Secretion Positive Regulation Of Leukocyte Migration Regulation Of CAMP Biosynthetic Process Positive Regulation Of Kinase Activity Phospholipase D-activating G-protein Coupled Receptor Signaling Pathway Protein Kinase C Deactivation Negative Regulation Of Biosynthetic Process Hormone Transport	Vasoconstriction Endothelin Receptor Signaling Pathway Blood Circulation Regulation Of Blood Vessel Size Regulation Of Tube Size Cellular Chemical Homeostasis Enteric Nervous System Development Vascular Smooth Muscle Contraction Cellular Homeostasis Regulation Of Blood Pressure Chemical Homeostasis Negative Regulation Of CAMP Biosynthetic Process Regulation Of Inflammatory Response Negative Regulation Of CAMP Metabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Nucleotide Metabolic Process Autonomic Nervous System Development Cellular Metal Ion Homeostasis Homeostatic Process Regulation Of Adenylate Cyclase Activity Cellular Cation Homeostasis Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Cellular Ion Homeostasis Regulation Of Cyclase Activity Metal Ion Homeostasis Neural Crest Cell Development Neural Crest Cell Differentiation Ion Homeostasis Regulation Of CAMP Biosynthetic Process Sensory Perception Of Pain Renal System Process Regulation Of CAMP Metabolic Process Enteric Smooth Muscle Cell Differentiation Interleukin-1 Beta Biosynthetic Process Mesenchymal Cell Development Mesenchymal Cell Differentiation Posterior Midgut Development Nervous System Development Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Cytosolic Calcium Ion Homeostasis Smooth Muscle Cell Proliferation Negative Regulation Of Neuron Maturation Mesenchyme Development Vein Smooth Muscle Contraction Fibroblast Proliferation Penile Erection Muscle Contraction
Tagcloud ?		aacr acquire arr1 arrb1 arrestin chemoresistance chemoresistant cisplatinum edn1 emt endothelin eoc et etar etbr impairing intravasation links macitentan overcome paucity pharmacologic potentiation rationale reorganization res sustain sustains vascularization	agouti albinism asip atf1 delta25 dopachrome edn1 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		aacr acquire arr1 arrb1 arrestin chemoresistance chemoresistant cisplatinum emt endothelin eoc et etar etbr impairing intravasation links macitentan overcome paucity pharmacologic potentiation rationale reorganization res sustain sustains vascularization	agouti albinism asip atf1 delta25 dopachrome ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?		edn1