EDNRA and HDAC7

Number of citations of the paper that reports this interaction (PubMedID 11262386)
0

Data Source:
BioGRID (affinity chromatography technology, pull down, two hybrid)

		EDNRA	HDAC7
Description		endothelin receptor type A	histone deacetylase 7
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Endothelin Receptor Activity Protein Binding	Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Hydrolase Activity SUMO Transferase Activity Protein Kinase Binding Protein Lysine Deacetylase Activity Metal Ion Binding 14-3-3 Protein Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism
	Biological Process	Mitotic Cell Cycle Angiogenesis Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia In Utero Embryonic Development Blood Vessel Remodeling Response To Amphetamine Regulation Of Heart Rate Heart Process Glomerular Filtration Cardiac Chamber Formation Left Ventricular Cardiac Muscle Tissue Morphogenesis Atrial Cardiac Muscle Tissue Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Noradrenergic Neuron Differentiation Intracellular Calcium Ion Homeostasis Smooth Muscle Contraction Mitochondrion Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Heart Development Respiratory Gaseous Exchange By Respiratory System Regulation Of Blood Pressure Cell Population Proliferation Response To Wounding Gene Expression Regulation Of D-glucose Transmembrane Transport Neural Crest Cell Development Neural Crest Cell Differentiation Neural Crest Cell Fate Commitment Artery Smooth Muscle Contraction Vascular Associated Smooth Muscle Contraction Neuron Remodeling Heparin Proteoglycan Metabolic Process Thyroid Gland Development Neuron Projection Development Glomerulus Development Cellular Response To Oxidative Stress Embryonic Heart Tube Development Aorta Development Vasoconstriction Norepinephrine Metabolic Process Middle Ear Morphogenesis Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Human Chorionic Gonadotropin Stimulus Developmental Pigmentation Enteric Nervous System Development Sympathetic Nervous System Development Axon Extension Embryonic Skeletal System Development Neuromuscular Process Sodium Ion Homeostasis Canonical Wnt Signaling Pathway Head Development Face Development Axonogenesis Involved In Innervation Establishment Of Endothelial Barrier Pharyngeal Arch Artery Morphogenesis Renal Sodium Ion Absorption Calcium Ion Transmembrane Transport Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Luteinizing Hormone Stimulus Protein Transmembrane Transport Glomerular Endothelium Development Podocyte Differentiation Endothelin Receptor Signaling Pathway Endothelin Receptor Signaling Pathway Involved In Heart Process Renal Albumin Absorption Vascular Associated Smooth Muscle Cell Development Mesenchymal Cell Apoptotic Process Cellular Response To Toxic Substance Sympathetic Neuron Axon Guidance CAMP/PKA Signal Transduction Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Podocyte Apoptotic Process Meiotic Cell Cycle Process Involved In Oocyte Maturation Cranial Skeletal System Development Response To Acetylcholine Regulation Of Protein Localization To Cell Leading Edge Positive Regulation Of Cation Channel Activity	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Chromatin Organization Protein Deacetylation Cell-cell Junction Assembly Negative Regulation Of Macromolecule Biosynthetic Process Protein Sumoylation Negative Regulation Of Interleukin-2 Production Epigenetic Regulation Of Gene Expression Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of MRNA Processing Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Membraneless Organelle Assembly Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SUMOylation of DNA damage response and repair proteins Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs		Bosentan Acetylsalicylic acid 2-HYDROXY-3,5-DIIODOBENZOIC ACID Darusentan SPP 301 Actelion-1 Atrasentan Sitaxentan Ambrisentan Enrasentan Tezosentan Clazosentan Macitentan Sparsentan	Valproic acid Decitabine Vorinostat Trichostatin A Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide
Diseases
GWAS		Carotid intima media thickness ( 21909108) Carotid plaque ( 30510157) Coronary artery disease ( 33020668 24262325 32469254 26343387 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Dental caries ( 23064961) Intracranial aneurysm ( 22286173) Lead levels ( 26025379) Myocardial infarction ( 33532862 26343387) Obesity-related traits ( 23251661) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Peripheral artery disease ( 26488411 31285632) Plasma clusterin levels ( 26545630) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Resting heart rate ( 27798624) Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome ( 30621171) Smoking initiation ( 33082346) Systolic blood pressure ( 27841878)	A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059 31361310 30929738) Asthma (adult onset) ( 31036433 30929738) Bipolar disorder ( 31043756) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Diastolic blood pressure ( 27841878) Fasting insulin ( 34059833) Haemorrhoidal disease ( 33888516) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Primary sclerosing cholangitis ( 23603763) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908) Urate levels ( 23263486) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: EDN1 EDN3 GNA11 GNAI2 GRK6 HDAC7 KAT5	59 interacting genes: ACOT11 ACTN4 ANTKMT ARID5A BCL6 BRWD1 C3orf36 CALCOCO2 CASP8 CDC42 CENPQ DDIT4L EDNRA EGFR ESM1 GNG12 GNMT GOLGA6L9 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 KAT5 KLF16 KRABD2 LDB2 MARK2 MARK3 MEF2A MEF2C MEOX2 MIEN1 MTCL2 NCOR2 NME4 NRIP2 PATJ PHC2 PPARD PPP1R16A PRKD1 PRKD2 RAC1 RAC2 RAC3 REL RIPPLY1 RRAS2 RUNX2 SIN3A SLC16A3 UBC UBE2I UBL3 YPEL3 YWHAG YWHAQ ZBTB16
Entrez ID		1909	51564
HPRD ID		00571	09133
Ensembl ID		ENSG00000151617	ENSG00000061273
Uniprot IDs		P25101	Q8WUI4
PDB IDs		8HCQ 8XVI 8XVJ 8XVK 8XVL	3C0Y 3C0Z 3C10 3ZNR 3ZNS 8Q9Q
Enriched GO Terms of Interacting Partners?		Vein Smooth Muscle Contraction Endothelin B Receptor Binding Regulation Of Systemic Arterial Blood Pressure By Endothelin Artery Smooth Muscle Contraction Tonic Smooth Muscle Contraction Positive Regulation Of Urine Volume Endothelin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Vascular Associated Smooth Muscle Contraction Guanyl Nucleotide Binding Regulation Of Urine Volume Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Blood Pressure Regulation Of Secretion By Cell G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Negative Regulation Of Interleukin-2 Production Positive Regulation Of Heart Rate Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Secretion Positive Regulation Of Smooth Muscle Contraction Vasoconstriction Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Heart Contraction Regulation Of Cell Differentiation Regulation Of Hormone Secretion Positive Regulation Of Cell Cycle Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Mitotic Nuclear Division Axon Extension Positive Regulation Of Secretion By Cell Positive Regulation Of Muscle Contraction Postsynaptic Signal Transduction Neural Crest Cell Migration Neutrophil Chemotaxis Positive Regulation Of Secretion Mesenchymal Cell Migration Smooth Muscle Contraction Positive Regulation Of Cell Cycle Regulation Of Smooth Muscle Contraction Regulation Of Interleukin-2 Production Regulation Of Vasoconstriction Neutrophil Migration	Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cell Migration Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Protein Lysine Deacetylase Activity Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Chromatin Binding Histone Deacetylase Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone Deacetylase Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Protein Lysine Delactylase Activity Negative Regulation Of Macromolecule Metabolic Process Transcription Repressor Complex Regulation Of RNA Metabolic Process Intracellular Signaling Cassette Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Cell Motility Regulation Of Striated Muscle Cell Differentiation Transcription Corepressor Binding Positive Regulation Of Locomotion Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cell Migration Regulation Of Cell Differentiation Regulation Of Gene Expression Neuron Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding NF-kappaB Binding Signal Transduction
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