EDNRA and GNA11

Number of citations of the paper that reports this interaction (PMID 10789830)
3

Data Source:
HPRD (in vitro)

		EDNRA	GNA11
Gene Name		endothelin receptor type A	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane T-tubule Nuclear Membrane Membrane Raft	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Endothelin Receptor Activity Protein Binding	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Patterning Of Blood Vessels Response To Hypoxia In Utero Embryonic Development Histamine Secretion Positive Regulation Of Protein Phosphorylation Glomerular Filtration Smooth Muscle Contraction Signal Transduction G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Heart Development Aging Respiratory Gaseous Exchange Metabolic Process Regulation Of Blood Pressure Cell Proliferation Positive Regulation Of Cell Proliferation Neural Crest Cell Development Artery Smooth Muscle Contraction Glucose Transport Sensory Perception Of Pain Negative Regulation Of CAMP Biosynthetic Process Response To Lipopolysaccharide Vasoconstriction Positive Regulation Of Odontogenesis Negative Regulation Of Apoptotic Process Penile Erection Response To Morphine Fibroblast Proliferation Enteric Nervous System Development Smooth Muscle Cell Proliferation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Maternal Process Involved In Parturition Head Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Endothelin Receptor Signaling Pathway Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Kidney Development	Skeletal System Development Action Potential Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Heart Development Blood Coagulation Platelet Activation Regulation Of Melanocyte Differentiation Developmental Pigmentation Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To PH
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion
Drugs		Bosentan 2-HYDROXY-3,5-DIIODOBENZOIC ACID Sitaxentan
Diseases
GWAS		Carotid intima media thickness ( 21909108) Dental caries ( 23064961) Intracranial aneurysm ( 22286173) Obesity-related traits ( 23251661)
Protein-Protein Interactions		7 interactors: EDN1 EDN3 GNA11 GNAI2 GRK6 HDAC7 KAT5	17 interactors: ADRA1B ADRB2 BDKRB2 CHRM2 EDNRA EDNRB HTR2A HTR2B KDR MTNR1A PTGIR RGS14 RGS3 SLC9A3R1 TBXA2R TRPC3 TSHR
Entrez ID		1909	2767
HPRD ID		00571	00759
Ensembl ID		ENSG00000151617
Uniprot IDs		P25101	P29992
PDB IDs
Enriched GO Terms of Interacting Partners?		Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Vascular Smooth Muscle Contraction Inositol Phosphate-mediated Signaling Negative Regulation Of Interleukin-2 Production Positive Regulation Of Heart Rate Regulation Of Developmental Pigmentation Cell Activation Signal Transduction Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Heart Contraction Cell Surface Receptor Signaling Pathway Negative Regulation Of CAMP Metabolic Process Vasoconstriction Signaling Cell Communication Negative Regulation Of Nucleotide Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Protein Modification Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Endothelial Cell Migration Regulation Of Vasoconstriction Smooth Muscle Contraction Cellular Response To Stimulus Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Developmental Pigmentation Peptide Hormone Secretion Neural Crest Cell Development Positive Regulation Of Leukocyte Chemotaxis Peptide Secretion Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Heart Rate Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Neural Crest Cell Differentiation Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Protein Kinase Activity Hormone Secretion Positive Regulation Of Leukocyte Migration Regulation Of CAMP Biosynthetic Process Positive Regulation Of Kinase Activity Phospholipase D-activating G-protein Coupled Receptor Signaling Pathway Protein Kinase C Deactivation Negative Regulation Of Biosynthetic Process Hormone Transport	G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Tube Size Vasoconstriction Regulation Of Phosphorus Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Homeostasis Blood Circulation Cytosolic Calcium Ion Homeostasis Ion Homeostasis Chemical Homeostasis Regulation Of MAPK Cascade Regulation Of Phosphorylation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Homeostatic Process Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Protein Phosphorylation Signal Transduction Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Cellular Chemical Homeostasis Signaling Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Cellular Metal Ion Homeostasis Cellular Homeostasis Cellular Cation Homeostasis Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Vasoconstriction Regulation Of Ion Homeostasis Vascular Smooth Muscle Contraction Regulation Of Blood Pressure Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Response To Abiotic Stimulus Regulation Of Signal Transduction Muscle Contraction Regulation Of CAMP Biosynthetic Process Positive Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Response To Stimulus Endothelin Receptor Signaling Pathway
Tagcloud ?		aacr acquire arr1 arrb1 arrestin chemoresistance chemoresistant cisplatinum edn1 emt endothelin eoc et etar etbr impairing intravasation links macitentan overcome paucity pharmacologic potentiation rationale reorganization res sustain sustains vascularization	amplifications backgroundendometrial cervix coexistent compatible conclusionsmolecular concurrently cul definite diagnose encourage endometrial extending fraumeni germline helps inversion jak3 massively mesothelioma ovaries peritoneal pik3ca pmm preoperatively presentationa sac urged vagina
Tagcloud (Difference) ?		aacr acquire arr1 arrb1 arrestin chemoresistance chemoresistant cisplatinum edn1 emt endothelin eoc et etar etbr impairing intravasation links macitentan overcome paucity pharmacologic potentiation rationale reorganization res sustain sustains vascularization	amplifications backgroundendometrial cervix coexistent compatible conclusionsmolecular concurrently cul definite diagnose encourage endometrial extending fraumeni germline helps inversion jak3 massively mesothelioma ovaries peritoneal pik3ca pmm preoperatively presentationa sac urged vagina
Tagcloud (Intersection) ?