KANSL1 and NINL

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KANSL1	NINL
Gene Name		KAT8 regulatory NSL complex subunit 1	ninein-like
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Condensed Chromosome Kinetochore Nucleus Nucleoplasm MLL1 Complex	Microtubule Organizing Center Cytosol Microtubule
	Molecular Function	Protein Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific)	Calcium Ion Binding
	Biological Process	Chromatin Organization Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		32 interactors: CALCOCO2 CCDC136 CCDC85B CDC5L CDR2 CEP70 DISC1 DTNBP1 EXOC1 FSD2 GOLGA2 HOOK2 KAT8 KDM1A KIFC3 KRT15 MAGEA12 NECAB2 NINL NUP62 NUTM1 PLEKHA5 PNMA1 PSME3 SMAD3 SPAG5 TFIP11 TP53 TRAF2 TRAF4 TRIM27 USHBP1	45 interactors: AKAP17A APEX2 CCDC130 CCDC146 CCDC33 CCHCR1 CLEC1B DCTN5 EWSR1 EZH2 FAM107A FAM161A GCC1 GPKOW HAUS1 JUNB KANSL1 KAT5 KAT7 L3MBTL4 LRSAM1 LZTS2 MAD1L1 MBIP MCM10 PLK1 RBM41 RCOR3 RGS2 RIBC2 SH2D4A SH3BP5L SPERT SYT17 TCEANC TCEB3 TNNT1 TSPYL4 UTP14A ZFC3H1 ZFHX3 ZNF250 ZNF417 ZNF426 ZNF646
Entrez ID		284058	22981
HPRD ID		11254	11120
Ensembl ID		ENSG00000120071	ENSG00000101004
Uniprot IDs		I3L4J3 Q7Z3B3	Q9Y2I6
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Cell Cycle Regulation Of Binding Cell Cycle Process Mitotic Cell Cycle Regulation Of Protein Binding Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Protein Homodimerization Activity Mitotic Cell Cycle Process Regulation Of Apoptotic Process Regulation Of Cellular Protein Metabolic Process Signal Transduction In Response To DNA Damage Regulation Of Cell Death Regulation Of Protein Homodimerization Activity Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Neural Precursor Cell Proliferation Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Stem Cell Proliferation Positive Regulation Of Proteolysis Viral Process Positive Regulation Of Signal Transduction Immune System Process Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Programmed Cell Death Positive Regulation Of Endopeptidase Activity Negative Regulation Of Cell Death Positive Regulation Of Peptidase Activity NIK/NF-kappaB Signaling DNA Damage Checkpoint Protein K63-linked Ubiquitination Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Cell Growth Positive Regulation Of Wnt Signaling Pathway Regulation Of Cellular Localization Protein Trimerization Cell Death Death Regulation Of Protein Phosphorylation Protein Polyubiquitination Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Protein Metabolic Process Programmed Necrotic Cell Death Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Necrotic Cell Death Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of RNA Biosynthetic Process	RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Gene Expression Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Peptidyl-lysine Modification Protein Acetylation Cellular Nitrogen Compound Metabolic Process Chromatin Organization Protein Localization To Chromatin Chromosome Organization Cell Cycle Histone H4-K5 Acetylation Histone H4-K8 Acetylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Chromatin Modification Histone Modification Regulation Of Transcription, DNA-templated Negative Regulation Of Muscle Contraction Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Organelle Organization Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Protein Localization To Chromosome Cell Cycle Process Mitotic Spindle Checkpoint Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Chromosome Segregation Mitotic Nuclear Division Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Ubiquitin-dependent Endocytosis Regulation Of Metaphase Plate Congression Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Muscle Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		acquisition amkl clone cohesin constitutive ctcf ds evolve evolves existing exome gata1 jak limiting lnk megakaryoblastic mostly mpl mutational myelopoiesis perinatal profiling remission resembling sh2b3 spontaneous tam trisomy whole
Tagcloud (Difference) ?		acquisition amkl clone cohesin constitutive ctcf ds evolve evolves existing exome gata1 jak limiting lnk megakaryoblastic mostly mpl mutational myelopoiesis perinatal profiling remission resembling sh2b3 spontaneous tam trisomy whole
Tagcloud (Intersection) ?