CCDC57 and IKZF3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCDC57	IKZF3
Description		coiled-coil domain containing 57	IKAROS family zinc finger 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Spindle Cytoskeleton Spindle Microtubule Centriolar Satellite	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity Promoter-specific Chromatin Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Centriole Replication Positive Regulation Of Mitotic Cell Cycle Cilium Assembly	Regulation Of Transcription By RNA Polymerase II Mesoderm Development Response To Bacterium B Cell Differentiation T Cell Differentiation Regulation Of B Cell Proliferation B Cell Activation Regulation Of Apoptotic Process Regulation Of B Cell Differentiation Regulation Of Lymphocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Proteinuria and chronic kidney disease ( 26420894) Refractive error ( 32231278)	Acute lymphoblastic leukemia (childhood) ( 29348612) Asthma ( 28461288 31959851 31619474) Asthma (moderate or severe) ( 30552067) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Asthma with severe exacerbations ( 32841424) Atopic march ( 26542096) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 21102463 28067908) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 23128233 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte count ( 29403010 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Marginal zone lymphoma or systemic lupus erythematosus ( 31407831) Multiple sclerosis ( 24076602 31604244) Neutrophil percentage of granulocytes ( 27863252) Pediatric autoimmune diseases ( 26301688) Polycystic ovary syndrome ( 30343302) Primary biliary cholangitis ( 20639880 23000144 30643196 28062665 19458352 26394269) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 24390342 23143596 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Systemic lupus erythematosus ( 27399966 26502338) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Type 1 diabetes ( 30659077 25751624) Ulcerative colitis ( 28067908 21297633 20228799)
Interacting Genes		148 interacting genes: ABI1 ABI2 ABLIM1 AMOTL2 ANKRD23 AQP1 ARID5A ARL4A AXIN1 BCAR3 BEX2 C19orf44 CATSPERT CBX8 CBY2 CCDC120 CCDC33 CDC20B CEP57L1 CFAP53 COIL CRTC2 CWF19L2 DCLK2 DISC1 DTX2 ECPAS EFHC2 EIF3D EIF4G1 ELOA EMILIN3 ESS2 FAM107A FAM161A FAM161B FAM228A FAM50B FAM90A1 FH FOXD4L1 FTO GFAP GIGYF1 GPBP1 GPKOW GRPEL1 HAUS1 HBA2 HDX IHO1 IKZF3 INCA1 INTS2 JRK KANK2 KIAA0408 KLF1 KLF15 KPRP KRT4 KRT76 KRTAP13-2 KRTAP13-3 LENG1 LINC00526 LZTS1 MAD1L1 MDM1 MFAP1 MT1E MYOZ3 NAB2 NAPRT NCOA5 NELFE NME4 NUMA1 PAK5 PER1 POM121 PPHLN1 PPP1R18 PRAM1 PRDM6 PROSER3 PRPF18 PRPF31 PRR3 PSMB4 PTCHD3 PTPN7 RAB3IL1 RASD1 RBM48 RDM1 RINT1 RNF6 ROBO3 RUSC1 RXRB SAXO4 SFI1 SH3KBP1 SHISA6 SIRPA SLC25A48 SMG9 SNRNP35 SORBS3 SPMIP2 SPMIP6 SPRY1 SYT6 TBC1D22B TCP10L TFIP11 TFPT TIMM44 TLE5 TMEM100 TNNI1 TP53BP2 TRIM14 TRIM29 TSEN54 TSGA10IP TSHZ2 TXLNA USP15 USP2 UTP14C VPS52 YJU2 ZBTB4 ZC2HC1C ZFC3H1 ZGPAT ZMAT2 ZNF417 ZNF436 ZNF474 ZNF552 ZNF648 ZNF655 ZNF688 ZNF835 ZSWIM3	157 interacting genes: ABLIM3 AIRIM AKAP10 AKAP9 ANKS1A AQP1 ARMC7 ARNT2 ATP6V0D1 ATP6V0D2 ATPAF2 ATXN7L2 BCAS2 BCL2L1 BLK BLZF1 BYSL CABP4 CABP5 CARD9 CATSPER1 CATSPERT CCDC102B CCDC187 CCDC24 CCDC57 CCHCR1 CDC37 CDC7 CDK4 CDKN1A CDKN2D CFAP206 CHCHD2 CHD3 CKS1B CLCNKA CRBN CRK CRYBA4 DGCR6 DTX2 EFHC1 EGLN3 EMC2 ENKD1 EXOC8 EXOSC5 FAM124B FANCG FANCL FARS2 FBF1 FHL3 FRS3 GEM GOLGA2 GOLGA6A GRAP2 GRB2 HNRNPF HNRNPLL HOXC8 HRAS IKZF1 IKZF4 IKZF5 ING5 KANK2 KAT5 KIF9 KIFC3 KLHL38 KRT19 LDOC1 LENG1 LGALS14 LMO1 LMO2 LMO4 LNX1 LONRF1 MAD2L2 MAGOHB MCM7 MCRS1 MID2 MISP MKRN3 MORN3 MRPL28 MRPL53 MYO15B NATD1 NEK6 NFKBID NME7 NOS3 NTAQ1 NUDT16L1 NXT2 OAZ3 OSGIN1 PCID2 PDZD4 PFDN5 PIK3R1 PIK3R2 PIN1 POLM POLR1C PPP1R16B PPP1R18 PRDM1 PRKAA1 PRKAA2 PRKAB2 PSMA1 PSMF1 RAD51D RBBP8 RCOR3 RHOA RNF6 RUNX1 SCNM1 SMARCB1 SMARCD1 SPG21 STAMBPL1 STK16 STK26 STX11 SUMO1 TBC1D22B TCAF1 TCAP TCEANC TCHP TEKT3 TEKT4 TFAP2D TLE5 TRAPPC6A TRIM42 TSEN15 TSGA10IP TSSK3 TSTD2 UBE2I USP2 VBP1 YES1 ZGPAT ZMYM2 ZNF587 ZNF76
Entrez ID		284001	22806
HPRD ID		14150	05869
Ensembl ID		ENSG00000176155	ENSG00000161405
Uniprot IDs		A0A590UJT6 Q2TAC2	Q9UKT9
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Spliceosomal Complex Nucleus Cytoskeleton MRNA Splicing, Via Spliceosome RNA Splicing Axonemal A Tubule Inner Sheath RNA Splicing, Via Transesterification Reactions	Protein Binding Nucleus Centrosome Microtubule-based Process Organelle Organization Cytoplasm Nucleoplasm Phosphotyrosine Residue Binding Cis-Golgi Network AMP-activated Protein Kinase Activity Microtubule Cytoskeleton Organization Lipid Droplet Disassembly Sperm Flagellum Microtubule Cytoskeleton Organization Involved In Mitosis Cytoskeleton Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Plasma Membrane Proton-transporting V-type ATPase Complex Axonemal A Tubule Inner Sheath Phosphatidylethanolamine Biosynthetic Process Protein K6-linked Ubiquitination Positive Regulation Of Lymphocyte Activation Regulation Of Mitotic Cell Cycle Nucleotide-activated Protein Kinase Complex Ephrin Receptor Binding Spindle Organization Microtubule Nucleation Cytoskeleton Organization Motile Cilium Regulation Of Autophagy Cyclin D2-CDK4 Complex Axonemal Microtubule Mitotic Spindle Organization Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Activation Regulation Of Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Cell Activation Regulation Of Lymphocyte Activation Hepatocyte Apoptotic Process Protein Localization To Lipid Droplet Organelle Assembly Regulation Of Cell Cycle
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