CCDC57 and ROBO3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		CCDC57	ROBO3
Description		coiled-coil domain containing 57	roundabout guidance receptor 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Spindle Cytoskeleton Spindle Microtubule Centriolar Satellite	Plasma Membrane Membrane Axon
	Molecular Function	Protein Binding	Protein Binding Cell-cell Adhesion Mediator Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Centriole Replication Positive Regulation Of Mitotic Cell Cycle Cilium Assembly	Neuron Migration Chemotaxis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Brain Development Axon Midline Choice Point Recognition Cell Differentiation Tube Development Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Dendrite Self-avoidance Commissural Neuron Axon Guidance Positive Regulation Of Axon Guidance
Pathways
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Proteinuria and chronic kidney disease ( 26420894) Refractive error ( 32231278)	Macular thickness ( 30535121)
Interacting Genes		148 interacting genes: ABI1 ABI2 ABLIM1 AMOTL2 ANKRD23 AQP1 ARID5A ARL4A AXIN1 BCAR3 BEX2 C19orf44 CATSPERT CBX8 CBY2 CCDC120 CCDC33 CDC20B CEP57L1 CFAP53 COIL CRTC2 CWF19L2 DCLK2 DISC1 DTX2 ECPAS EFHC2 EIF3D EIF4G1 ELOA EMILIN3 ESS2 FAM107A FAM161A FAM161B FAM228A FAM50B FAM90A1 FH FOXD4L1 FTO GFAP GIGYF1 GPBP1 GPKOW GRPEL1 HAUS1 HBA2 HDX IHO1 IKZF3 INCA1 INTS2 JRK KANK2 KIAA0408 KLF1 KLF15 KPRP KRT4 KRT76 KRTAP13-2 KRTAP13-3 LENG1 LINC00526 LZTS1 MAD1L1 MDM1 MFAP1 MT1E MYOZ3 NAB2 NAPRT NCOA5 NELFE NME4 NUMA1 PAK5 PER1 POM121 PPHLN1 PPP1R18 PRAM1 PRDM6 PROSER3 PRPF18 PRPF31 PRR3 PSMB4 PTCHD3 PTPN7 RAB3IL1 RASD1 RBM48 RDM1 RINT1 RNF6 ROBO3 RUSC1 RXRB SAXO4 SFI1 SH3KBP1 SHISA6 SIRPA SLC25A48 SMG9 SNRNP35 SORBS3 SPMIP2 SPMIP6 SPRY1 SYT6 TBC1D22B TCP10L TFIP11 TFPT TIMM44 TLE5 TMEM100 TNNI1 TP53BP2 TRIM14 TRIM29 TSEN54 TSGA10IP TSHZ2 TXLNA USP15 USP2 UTP14C VPS52 YJU2 ZBTB4 ZC2HC1C ZFC3H1 ZGPAT ZMAT2 ZNF417 ZNF436 ZNF474 ZNF552 ZNF648 ZNF655 ZNF688 ZNF835 ZSWIM3	9 interacting genes: APP CCDC57 CXCL14 HSF2BP LNX1 MTUS2 NEDD4L PICK1 RBMX
Entrez ID		284001	64221
HPRD ID		14150	10554
Ensembl ID		ENSG00000176155	ENSG00000154134
Uniprot IDs		A0A590UJT6 Q2TAC2	Q96MS0
PDB IDs			6POG 6POK 6POL
Enriched GO Terms of Interacting Partners?		Protein Binding Spliceosomal Complex Nucleus Cytoskeleton MRNA Splicing, Via Spliceosome RNA Splicing Axonemal A Tubule Inner Sheath RNA Splicing, Via Transesterification Reactions	Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor Internalization Glial Cell Development Synapse Organization Regulation Of Endocytosis Plasma Membrane Bounded Cell Projection Organization G Protein-coupled Receptor Binding Regulation Of Receptor Internalization Acetylcholine Receptor Activator Activity PTB Domain Binding Response To Interleukin-1 Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Cell Junction Organization Cell Projection Organization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Membrane Curvature Sensor Activity Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Caveolin-mediated Endocytosis Supraspliceosomal Complex Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Regulation Of Vesicle-mediated Transport Main Axon Regulation Of Spontaneous Synaptic Transmission
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