CCDC57 and PRAM1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		CCDC57	PRAM1
Description		coiled-coil domain containing 57	PML-RARA regulated adaptor molecule 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Spindle Cytoskeleton Spindle Microtubule Centriolar Satellite	Plasma Membrane Protein-containing Complex
	Molecular Function	Protein Binding	Protein Binding Lipid Binding Protein Kinase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Centriole Replication Positive Regulation Of Mitotic Cell Cycle Cilium Assembly	Integrin-mediated Signaling Pathway Regulation Of Neutrophil Degranulation T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Proteinuria and chronic kidney disease ( 26420894) Refractive error ( 32231278)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Coronary artery disease ( 29212778) Height ( 18391951)
Interacting Genes		148 interacting genes: ABI1 ABI2 ABLIM1 AMOTL2 ANKRD23 AQP1 ARID5A ARL4A AXIN1 BCAR3 BEX2 C19orf44 CATSPERT CBX8 CBY2 CCDC120 CCDC33 CDC20B CEP57L1 CFAP53 COIL CRTC2 CWF19L2 DCLK2 DISC1 DTX2 ECPAS EFHC2 EIF3D EIF4G1 ELOA EMILIN3 ESS2 FAM107A FAM161A FAM161B FAM228A FAM50B FAM90A1 FH FOXD4L1 FTO GFAP GIGYF1 GPBP1 GPKOW GRPEL1 HAUS1 HBA2 HDX IHO1 IKZF3 INCA1 INTS2 JRK KANK2 KIAA0408 KLF1 KLF15 KPRP KRT4 KRT76 KRTAP13-2 KRTAP13-3 LENG1 LINC00526 LZTS1 MAD1L1 MDM1 MFAP1 MT1E MYOZ3 NAB2 NAPRT NCOA5 NELFE NME4 NUMA1 PAK5 PER1 POM121 PPHLN1 PPP1R18 PRAM1 PRDM6 PROSER3 PRPF18 PRPF31 PRR3 PSMB4 PTCHD3 PTPN7 RAB3IL1 RASD1 RBM48 RDM1 RINT1 RNF6 ROBO3 RUSC1 RXRB SAXO4 SFI1 SH3KBP1 SHISA6 SIRPA SLC25A48 SMG9 SNRNP35 SORBS3 SPMIP2 SPMIP6 SPRY1 SYT6 TBC1D22B TCP10L TFIP11 TFPT TIMM44 TLE5 TMEM100 TNNI1 TP53BP2 TRIM14 TRIM29 TSEN54 TSGA10IP TSHZ2 TXLNA USP15 USP2 UTP14C VPS52 YJU2 ZBTB4 ZC2HC1C ZFC3H1 ZGPAT ZMAT2 ZNF417 ZNF436 ZNF474 ZNF552 ZNF648 ZNF655 ZNF688 ZNF835 ZSWIM3	26 interacting genes: A2M ABI2 APOE APP BCAR1 CCDC57 CDC37 CEBPA FXR1 FXR2 GOLGA2 KRT40 LCP2 LYN MAST1 MXD1 NEDD9 NEK6 PSEN1 RNF32 SH3RF1 SKAP1 SKAP2 TP53BP2 TRIM27 UBE2E2
Entrez ID		284001	84106
HPRD ID		14150	05926
Ensembl ID		ENSG00000176155	ENSG00000133246
Uniprot IDs		A0A590UJT6 Q2TAC2	Q96QH2
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Spliceosomal Complex Nucleus Cytoskeleton MRNA Splicing, Via Spliceosome RNA Splicing Axonemal A Tubule Inner Sheath RNA Splicing, Via Transesterification Reactions	Positive Regulation Of Protein Metabolic Process Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Long-term Synaptic Potentiation SH3 Domain Binding Regulation Of Dendritic Spine Maintenance Regulation Of Immune System Process Regulation Of Neuronal Synaptic Plasticity Regulation Of Postsynapse Organization Lipoprotein Particle Regulation Of Amyloid Fibril Formation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Regulation Of Immune Response Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Proteolysis Regulation Of Synaptic Plasticity Astrocyte Activation Involved In Immune Response Positive Regulation Of Protein Catabolic Process Intermediate-density Lipoprotein Particle Positive Regulation Of Dendritic Spine Maintenance Growth Factor Receptor Binding T Cell Receptor Signaling Pathway Memory Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Long-term Synaptic Potentiation Cytoplasm Learning Or Memory Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Amyloid-beta Signaling Receptor Activator Activity Regulation Of Amyloid Precursor Protein Catabolic Process Cytoskeleton Organization Regulation Of Synapse Organization Cytosol Supramolecular Fiber Organization Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Immune System Process Cognition Positive Regulation Of Phosphate Metabolic Process Response To Amyloid-beta Neuron Projection Positive Regulation Of Metabolic Process Regulation Of Defense Response Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Neuron Projection Maintenance
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