CCDC57 and RNF6

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		CCDC57	RNF6
Description		coiled-coil domain containing 57	ring finger protein 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Spindle Cytoskeleton Spindle Microtubule Centriolar Satellite	Nucleus Cytoplasm PML Body Axon Nuclear Membrane Cell Projection
	Molecular Function	Protein Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Nuclear Androgen Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Centriole Replication Positive Regulation Of Mitotic Cell Cycle Cilium Assembly	Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Axon Extension Protein K27-linked Ubiquitination Positive Regulation Of DNA-templated Transcription Axon Extension Regulation Of Androgen Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Proteinuria and chronic kidney disease ( 26420894) Refractive error ( 32231278)	Sporadic pituitary adenoma ( 26029870) Type 2 diabetes ( 24509480 28869590 30297969 30718926 32499647) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		148 interacting genes: ABI1 ABI2 ABLIM1 AMOTL2 ANKRD23 AQP1 ARID5A ARL4A AXIN1 BCAR3 BEX2 C19orf44 CATSPERT CBX8 CBY2 CCDC120 CCDC33 CDC20B CEP57L1 CFAP53 COIL CRTC2 CWF19L2 DCLK2 DISC1 DTX2 ECPAS EFHC2 EIF3D EIF4G1 ELOA EMILIN3 ESS2 FAM107A FAM161A FAM161B FAM228A FAM50B FAM90A1 FH FOXD4L1 FTO GFAP GIGYF1 GPBP1 GPKOW GRPEL1 HAUS1 HBA2 HDX IHO1 IKZF3 INCA1 INTS2 JRK KANK2 KIAA0408 KLF1 KLF15 KPRP KRT4 KRT76 KRTAP13-2 KRTAP13-3 LENG1 LINC00526 LZTS1 MAD1L1 MDM1 MFAP1 MT1E MYOZ3 NAB2 NAPRT NCOA5 NELFE NME4 NUMA1 PAK5 PER1 POM121 PPHLN1 PPP1R18 PRAM1 PRDM6 PROSER3 PRPF18 PRPF31 PRR3 PSMB4 PTCHD3 PTPN7 RAB3IL1 RASD1 RBM48 RDM1 RINT1 RNF6 ROBO3 RUSC1 RXRB SAXO4 SFI1 SH3KBP1 SHISA6 SIRPA SLC25A48 SMG9 SNRNP35 SORBS3 SPMIP2 SPMIP6 SPRY1 SYT6 TBC1D22B TCP10L TFIP11 TFPT TIMM44 TLE5 TMEM100 TNNI1 TP53BP2 TRIM14 TRIM29 TSEN54 TSGA10IP TSHZ2 TXLNA USP15 USP2 UTP14C VPS52 YJU2 ZBTB4 ZC2HC1C ZFC3H1 ZGPAT ZMAT2 ZNF417 ZNF436 ZNF474 ZNF552 ZNF648 ZNF655 ZNF688 ZNF835 ZSWIM3	39 interacting genes: AHCYL1 AR CBY2 CCDC33 CCDC57 CDKN1B CEP70 GOLGA2 HOOK2 IKZF1 IKZF3 KIAA0753 KRT15 KRT40 LDOC1 MAGED1 MDFI MEOX2 MID2 MIPOL1 MTUS2 PNMA2 REL RINT1 RPGRIP1 SSX2IP STK4 STX11 TADA2A TFIP11 TNS2 TP53 TRIM23 TRIM27 TRIM37 TSGA10 UBE2C UBE2D1 UBE2H
Entrez ID		284001	6049
HPRD ID		14150	05027
Ensembl ID		ENSG00000176155	ENSG00000127870
Uniprot IDs		A0A590UJT6 Q2TAC2	A0A024RDP2 A0A0S2Z4G9 Q9Y252
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Spliceosomal Complex Nucleus Cytoskeleton MRNA Splicing, Via Spliceosome RNA Splicing Axonemal A Tubule Inner Sheath RNA Splicing, Via Transesterification Reactions	Identical Protein Binding Intracellular Transport Cytoskeleton Ubiquitin-protein Transferase Activity Microtubule Organizing Center Organization Cytoplasm Protein Binding Cellular Localization Establishment Of Localization In Cell Centrosome Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Activity Cell Projection Assembly Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Antibiotic Cilium Assembly Negative Regulation Of Epithelial Cell Proliferation Intracellular Protein Localization Protein Ubiquitination Transcription Coactivator Activity Cilium Organization Protein Transport Negative Regulation Of Viral Transcription Regulation Of Exit From Mitosis Suppression Of Viral Release By Host Protein Modification By Small Protein Conjugation Organelle Organization Regulation Of Viral Transcription Organelle Assembly Negative Regulation Of Cell Population Proliferation Intracellular Protein Transport Protein Tetramerization Cell Differentiation Involved In Embryonic Placenta Development Plasma Membrane Bounded Cell Projection Assembly
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