GNAO1 and PTPRU

Number of citations of the paper that reports this interaction (PubMedID 10196137)
0

Data Source:
HPRD (in vitro, in vivo)

		GNAO1	PTPRU
Description		G protein subunit alpha o1	protein tyrosine phosphatase receptor type U
Image
GO Annotations	Cellular Component	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Presynaptic Membrane Cell Body Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Glutamatergic Synapse GABA-ergic Synapse	Plasma Membrane Cell-cell Junction Membrane Anchoring Junction
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Adenylate Cyclase Regulator Activity Hydrolase Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Hydrolase Activity
	Biological Process	Vesicle Docking Involved In Exocytosis Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Locomotory Behavior Regulation Of Heart Contraction Negative Regulation Of Insulin Secretion Postsynaptic Modulation Of Chemical Synaptic Transmission	Protein Dephosphorylation Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Negative Regulation Of Cell Population Proliferation Cell Differentiation Negative Regulation Of Cell Migration Animal Organ Regeneration Neuron Projection Development Homotypic Cell-cell Adhesion Protein Localization To Cell Surface Response To Glucocorticoid Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Ca2+ pathway Ca2+ pathway	Signaling by SCF-KIT
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cardioembolic stroke (CCSp classification) ( 32047268) Chronotype ( 30696823) Daytime nap ( 33568662) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) HDL cholesterol levels ( 32203549) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)	Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Bipolar disorder and schizophrenia ( 20889312) Blood protein levels ( 30072576) Carotid plaque maximum area ( 32469969) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol levels ( 32203549) Mean area of carotid plaque ( 32469969) Mean corpuscular volume ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Schizophrenia ( 28991256) Tourette syndrome ( 30818990)
Interacting Genes		36 interacting genes: ADORA1 ADRA2A ADRA2C APLP2 CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR ZBTB16	12 interacting genes: CTNNB1 EGFR ERBB2 GNAI1 GNAI2 GNAI3 GNAO1 IRS1 KIT OMG OSTN PPFIA3
Entrez ID		2775	10076
HPRD ID		00757	03908
Ensembl ID		ENSG00000087258	ENSG00000060656
Uniprot IDs		B3KP89 P09471 Q8N6I9	Q92729
PDB IDs		6FUF 6G79 6K41 6OIK 6WWZ 7D76 7D77 7EJ0 7EJ8 7EJA 7EJK 7QVM 7T8X 7T90 7T94 7T96 7W2Z 7W6P 7W7E 7XJJ 7Y24 8DZQ 8E9X 8FN1 8HPT 8HQC 8I95 8I97 8I9L 8I9S 8IA2 8IEC 8IED 8IY9 8IYH 8IYW 8J6D 8JER 8JHN 8JZP 8JZZ 8TZQ 8U02 8XWV 8XX3 8XX6 8XX7 8XXH 8XXR 8XXX 8XXZ 8XYK 8Y0N 8YN7 8YN8 9F33 9F34	6SUB 6SUC
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G-protein Alpha-subunit Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Plasma Membrane Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway GTPase Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Secretion By Cell Regulation Of Signaling GTPase Activator Activity Negative Regulation Of Secretion Negative Regulation Of Epinephrine Secretion Negative Regulation Of Transport Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion Regulation Of Amine Transport Regulation Of Hormone Secretion G Protein-coupled Peptide Receptor Activity Negative Regulation Of Insulin Secretion Negative Regulation Of Catecholamine Secretion Membrane Regulation Of Secretion By Cell Negative Regulation Of Peptide Secretion Negative Regulation Of Amino Acid Transport GDP-dissociation Inhibitor Activity Regulation Of Secretion G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Protein Transport Negative Regulation Of Establishment Of Protein Localization G Protein-coupled Acetylcholine Receptor Signaling Pathway Alpha2-adrenergic Receptor Activity Response To Alcohol Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Regulation Of Biological Quality Positive Regulation Of GTPase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signaling Positive Regulation Of ERBB Signaling Pathway Dendrite Regulation Of Signal Transduction Cell Communication Regulation Of MAPK Cascade Regulation Of Peptide Hormone Secretion Negative Regulation Of Norepinephrine Secretion	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Ciliary Basal Body Negative Regulation Of Insulin Secretion Negative Regulation Of Secretion By Cell Adenylate Cyclase Regulator Activity Negative Regulation Of Peptide Secretion Negative Regulation Of Secretion Transmembrane Receptor Protein Tyrosine Kinase Activity Midbody Negative Regulation Of Transport Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB2-EGFR Signaling Pathway ERBB Signaling Pathway Plasma Membrane Basolateral Plasma Membrane Cell Surface Receptor Signaling Pathway Negative Regulation Of Hormone Secretion G Protein-coupled Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Protein Secretion Negative Regulation Of Adenylate Cyclase Activity Regulation Of Protein Localization Positive Regulation Of Cell Population Proliferation Presynaptic Active Zone Cytoplasmic Component Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Binding GTPase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Transport Nucleotide Binding Protein Tyrosine Kinase Activity G Protein-coupled Serotonin Receptor Signaling Pathway Signal Transduction GTP Binding Cell Population Proliferation Presynaptic Membrane ERBB2 Signaling Pathway Negative Regulation Of Establishment Of Protein Localization Signaling Receptor Binding Regulation Of Cell Communication
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?