GNAO1 and RGS10

Number of citations of the paper that reports this interaction (PMID 15215290)
17

Data Source:
HPRD (two hybrid)

		GNAO1	RGS10
Gene Name		guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	regulator of G-protein signaling 10
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Neuron Projection	Nucleus Cytoplasm Plasma Membrane Neuronal Cell Body Dendritic Spine Axon Terminus
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	GTPase Activator Activity
	Biological Process	Muscle Contraction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport	Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		Signaling by GPCR Ca2+ pathway PLC beta mediated events G-protein activation Opioid Signalling Signaling by Wnt G-protein mediated events beta-catenin independent WNT signaling	Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	9 interactors: ADRB2 APP CALM1 GNAI1 GNAI3 GNAO1 GNAZ GNRHR PRKACA
Entrez ID		2775	6001
HPRD ID		00757	04172
Ensembl ID		ENSG00000087258	ENSG00000148908
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	O43665
PDB IDs			2DLR 2I59 2IHB
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Positive Regulation Of ERBB Signaling Pathway Signaling Cell Communication Signal Transduction Cell-cell Signaling Neurological System Process Regulation Of Signal Transduction Locomotory Behavior Positive Regulation Of GTPase Activity Negative Regulation Of Epinephrine Secretion Regulation Of Sensory Perception Of Pain Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Behavior Regulation Of ERBB Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Cellular Response To Stimulus Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Sensory Perception Regulation Of Neurological System Process Regulation Of Adenylate Cyclase Activity Negative Regulation Of Smooth Muscle Contraction Regulation Of Ion Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Cyclase Activity Single-organism Behavior Regulation Of MAP Kinase Activity Negative Regulation Of Secretion By Cell	G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Adenylate Cyclase Activity Platelet Activation Regulation Of Cyclase Activity Cell Surface Receptor Signaling Pathway Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Activation Of Adenylate Cyclase Activity Blood Coagulation Hemostasis Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Regulation Of Body Fluid Levels Wound Healing Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Signal Transduction Positive Regulation Of CAMP Metabolic Process Cell Activation Response To Wounding Signaling Cell Communication Positive Regulation Of Cyclic Nucleotide Metabolic Process Response To Organonitrogen Compound Cellular Response To Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Protein Binding Regulation Of Muscle Contraction Regulation Of Heart Contraction Negative Regulation Of Adenylate Cyclase Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Lyase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Stress Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Calcium Ion Transport Synaptic Transmission Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of CAMP Biosynthetic Process Regulation Of Ion Transport Rhodopsin Mediated Signaling Pathway Negative Regulation Of CAMP Metabolic Process Regulation Of Catalytic Activity Response To Stimulus Vesicle-mediated Transport Regulation Of Phosphorus Metabolic Process Negative Regulation Of Nucleotide Metabolic Process
Tagcloud ?		aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	alveolar avenues bones combat craniofacial destruction forearm isoflavone menopausal microbe mkp multipotent nfatc1 oscillation oscillations osteoclast osteoclastogenesis periodontal periodontitis periosteum relate resorption rgs12 soy sscs supplementation supplements tolerability unsatisfactory
Tagcloud (Difference) ?		aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	alveolar avenues bones combat craniofacial destruction forearm isoflavone menopausal microbe mkp multipotent nfatc1 oscillation oscillations osteoclast osteoclastogenesis periodontal periodontitis periosteum relate resorption rgs12 soy sscs supplementation supplements tolerability unsatisfactory
Tagcloud (Intersection) ?