GNAO1 and NUCB1

Number of citations of the paper that reports this interaction (PMID 9647645)
28

Data Source:
HPRD (in vitro, two hybrid)

		GNAO1	NUCB1
Gene Name		guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	nucleobindin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Neuron Projection	Extracellular Space Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Microtubule Cytoskeleton Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	DNA Binding Calcium Ion Binding Protein Binding
	Biological Process	Muscle Contraction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport
Pathways		Signaling by GPCR Ca2+ pathway PLC beta mediated events G-protein activation Opioid Signalling Signaling by Wnt G-protein mediated events beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	15 interactors: GNAI1 GNAI2 GNAI3 GNAO1 GNAS GNAZ HIVEP1 MYC NDN PTGS1 PTGS2 RBL1 REL SET XPO1
Entrez ID		2775	4924
HPRD ID		00757	03205
Ensembl ID		ENSG00000087258	ENSG00000104805
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	A8K7Q1 Q02818
PDB IDs			1SNL
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Positive Regulation Of ERBB Signaling Pathway Signaling Cell Communication Signal Transduction Cell-cell Signaling Neurological System Process Regulation Of Signal Transduction Locomotory Behavior Positive Regulation Of GTPase Activity Negative Regulation Of Epinephrine Secretion Regulation Of Sensory Perception Of Pain Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Behavior Regulation Of ERBB Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Cellular Response To Stimulus Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Sensory Perception Regulation Of Neurological System Process Regulation Of Adenylate Cyclase Activity Negative Regulation Of Smooth Muscle Contraction Regulation Of Ion Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Cyclase Activity Single-organism Behavior Regulation Of MAP Kinase Activity Negative Regulation Of Secretion By Cell	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Response To Organic Substance Platelet Activation Regulation Of Adenylate Cyclase Activity Cell Cycle Regulation Of Cyclase Activity Response To Drug Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of CAMP Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Signal Transduction Regulation Of CAMP Metabolic Process Regulation Of Cellular Process Cyclooxygenase Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process G-protein Coupled Receptor Signaling Pathway Response To Stimulus Response To Stress Signaling Prostaglandin Biosynthetic Process Cell Communication Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Gene Expression Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Lyase Activity Blood Coagulation Hemostasis Prostaglandin Metabolic Process Negative Regulation Of CAMP Biosynthetic Process Regulation Of Metabolic Process Dopamine Receptor Signaling Pathway Negative Regulation Of CAMP Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Genetic Imprinting Regulation Of Calcium Ion Transport Response To Transforming Growth Factor Beta Negative Regulation Of Nucleotide Metabolic Process Metabolic Process Negative Regulation Of Calcium Ion Transport Regulation Of Catalytic Activity Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus
Tagcloud ?		aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Difference) ?		aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Intersection) ?