GNAO1 and RGS4

Number of citations of the paper that reports this interaction (PMID 9660808)
11

Data Source:
HPRD (in vitro)

		GNAO1	RGS4
Gene Name		guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	regulator of G-protein signaling 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Neuron Projection	Cytoplasm Cytosol Plasma Membrane Protein Complex
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	G-protein Alpha-subunit Binding GTPase Activator Activity Calmodulin Binding
	Biological Process	Muscle Contraction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport	Inactivation Of MAPK Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		Signaling by GPCR Ca2+ pathway PLC beta mediated events G-protein activation Opioid Signalling Signaling by Wnt G-protein mediated events beta-catenin independent WNT signaling	Signaling by GPCR GPCR downstream signaling G alpha (z) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	12 interactors: CALM1 COPB1 COPB2 ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KRIT1 PLCB1 PTAFR
Entrez ID		2775	5999
HPRD ID		00757	03947
Ensembl ID		ENSG00000087258	ENSG00000117152
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	P49798
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Positive Regulation Of ERBB Signaling Pathway Signaling Cell Communication Signal Transduction Cell-cell Signaling Neurological System Process Regulation Of Signal Transduction Locomotory Behavior Positive Regulation Of GTPase Activity Negative Regulation Of Epinephrine Secretion Regulation Of Sensory Perception Of Pain Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Behavior Regulation Of ERBB Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Cellular Response To Stimulus Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Sensory Perception Regulation Of Neurological System Process Regulation Of Adenylate Cyclase Activity Negative Regulation Of Smooth Muscle Contraction Regulation Of Ion Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Cyclase Activity Single-organism Behavior Regulation Of MAP Kinase Activity Negative Regulation Of Secretion By Cell	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Inositol Phosphate Metabolic Process Platelet Activation Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Cyclase Activity Synaptic Transmission Wound Healing Regulation Of CAMP Biosynthetic Process Signal Transduction Cell Activation Response To Wounding COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Regulation Of CAMP Metabolic Process G-protein Coupled Acetylcholine Receptor Signaling Pathway Golgi Vesicle Budding Signaling Cell Communication Regulation Of Phosphorus Metabolic Process Blood Coagulation Hemostasis Positive Regulation Of Catalytic Activity Cell-cell Signaling Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Cellular Response To Stimulus Vesicle Targeting, To, From Or Within Golgi Regulation Of Calcium Ion Transport Negative Regulation Of CAMP Metabolic Process Dopamine Receptor Signaling Pathway Intracellular Signal Transduction Vesicle Organization Regulation Of Body Fluid Levels Retrograde Vesicle-mediated Transport, Golgi To ER Negative Regulation Of Nucleotide Metabolic Process Negative Regulation Of Calcium Ion Transport Vesicle Targeting Localization Within Membrane Regulation Of Phosphorylation Activation Of Phospholipase C Activity Intra-Golgi Vesicle-mediated Transport Regulation Of Protein Kinase Activity Positive Regulation Of Phospholipase C Activity
Tagcloud ?		aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	102kspsklsp109 adenylyl anandamide anticipated arrestin1 beta3 cb1 conform contraction endowed engage erk1 galphai galphaq gbetagamma gi grk5 k215r minigene mlc myosin mypt1 ptx rhoa rip ser103 ser108 signaled uncoupling
Tagcloud (Difference) ?		aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	102kspsklsp109 adenylyl anandamide anticipated arrestin1 beta3 cb1 conform contraction endowed engage erk1 galphai galphaq gbetagamma gi grk5 k215r minigene mlc myosin mypt1 ptx rhoa rip ser103 ser108 signaled uncoupling
Tagcloud (Intersection) ?