GNAO1 and ADORA1

Number of citations of the paper that reports this interaction (PubMedID 10521440)
0

Data Source:
HPRD (in vivo)

		GNAO1	ADORA1
Description		G protein subunit alpha o1	adenosine A1 receptor
Image
GO Annotations	Cellular Component	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Presynaptic Membrane Cell Body Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Glutamatergic Synapse GABA-ergic Synapse	Plasma Membrane Cilium Membrane Basolateral Plasma Membrane Dendrite Axolemma Asymmetric Synapse Presynaptic Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine Cell Body Calyx Of Held Synapse Postsynaptic Membrane Presynaptic Active Zone
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Adenylate Cyclase Regulator Activity Hydrolase Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Receptor Binding Purine Nucleoside Binding G Protein-coupled Receptor Activity Protein Binding Heat Shock Protein Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity
	Biological Process	Vesicle Docking Involved In Exocytosis Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Locomotory Behavior Regulation Of Heart Contraction Negative Regulation Of Insulin Secretion Postsynaptic Modulation Of Chemical Synaptic Transmission	Temperature Homeostasis Response To Hypoxia G Protein-coupled Adenosine Receptor Signaling Pathway Regulation Of Respiratory Gaseous Exchange By Nervous System Process Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Leukocyte Migration Positive Regulation Of Peptide Secretion Positive Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Glomerular Filtration Protein Targeting To Membrane Phagocytosis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Glutamate Secretion Response To Purine-containing Compound Lipid Catabolic Process Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Nucleoside Transport Negative Regulation Of Neurotrophin Production Positive Regulation Of Dephosphorylation G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Vasodilation Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Apoptotic Process Positive Regulation Of Potassium Ion Transport Positive Regulation Of MAPK Cascade Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Negative Regulation Of Hormone Secretion Negative Regulation Of Inflammatory Response Cognition Leukocyte Migration Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Sensory Perception Of Pain Negative Regulation Of Synaptic Transmission, Glutamatergic Fatty Acid Homeostasis Regulation Of Cardiac Muscle Contraction Excitatory Postsynaptic Potential Long-term Synaptic Depression Mucus Secretion Negative Regulation Of Mucus Secretion Triglyceride Homeostasis Regulation Of Cardiac Muscle Cell Contraction Apoptotic Signaling Pathway Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Depression
Pathways		Ca2+ pathway Ca2+ pathway	Adenosine P1 receptors G alpha (i) signalling events
Drugs			Tramadol Caffeine Theophylline Lamotrigine Adenosine Dyphylline Pentoxifylline Enprofylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide Tecadenoson Naxifylline Cannabidiol Istradefylline Tonapofylline Rolofylline
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cardioembolic stroke (CCSp classification) ( 32047268) Chronotype ( 30696823) Daytime nap ( 33568662) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) HDL cholesterol levels ( 32203549) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)	Asthma ( 27182965 30929738 31361310 31619474 31959851 32296059) Asthma (childhood onset) ( 30929738 31036433) Clozapine-induced agranulocytosis ( 25187353) Systolic blood pressure ( 30224653) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		36 interacting genes: ADORA1 ADRA2A ADRA2C APLP2 CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR ZBTB16	12 interacting genes: ADA ATXN1L DRD1 EPB41L2 GNAI2 GNAO1 GNAS GNAZ GRM1 P2RY1 SNF8 TSHR
Entrez ID		2775	134
HPRD ID		00757	00042
Ensembl ID		ENSG00000087258	ENSG00000163485
Uniprot IDs		B3KP89 P09471 Q8N6I9	B7Z1L9 B7Z379 P30542
PDB IDs		6FUF 6G79 6K41 6OIK 6WWZ 7D76 7D77 7EJ0 7EJ8 7EJA 7EJK 7QVM 7T8X 7T90 7T94 7T96 7W2Z 7W6P 7W7E 7XJJ 7Y24 8DZQ 8E9X 8FN1 8HPT 8HQC 8I95 8I97 8I9L 8I9S 8IA2 8IEC 8IED 8IY9 8IYH 8IYW 8J6D 8JER 8JHN 8JZP 8JZZ 8TZQ 8U02 8XWV 8XX3 8XX6 8XX7 8XXH 8XXR 8XXX 8XXZ 8XYK 8Y0N 8YN7 8YN8 9F33 9F34	5N2S 5UEN 6D9H 7LD3 7LD4
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G-protein Alpha-subunit Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Plasma Membrane Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway GTPase Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Secretion By Cell Regulation Of Signaling GTPase Activator Activity Negative Regulation Of Secretion Negative Regulation Of Epinephrine Secretion Negative Regulation Of Transport Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion Regulation Of Amine Transport Regulation Of Hormone Secretion G Protein-coupled Peptide Receptor Activity Negative Regulation Of Insulin Secretion Negative Regulation Of Catecholamine Secretion Membrane Regulation Of Secretion By Cell Negative Regulation Of Peptide Secretion Negative Regulation Of Amino Acid Transport GDP-dissociation Inhibitor Activity Regulation Of Secretion G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Protein Transport Negative Regulation Of Establishment Of Protein Localization G Protein-coupled Acetylcholine Receptor Signaling Pathway Alpha2-adrenergic Receptor Activity Response To Alcohol Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Regulation Of Biological Quality Positive Regulation Of GTPase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signaling Positive Regulation Of ERBB Signaling Pathway Dendrite Regulation Of Signal Transduction Cell Communication Regulation Of MAPK Cascade Regulation Of Peptide Hormone Secretion Negative Regulation Of Norepinephrine Secretion	Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex Dendrite G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Secretion Regulation Of Secretion Cell Body G Protein-coupled Dopamine Receptor Signaling Pathway Mu-type Opioid Receptor Binding Plasma Membrane G Protein-coupled Serotonin Receptor Binding Regulation Of Secretion By Cell System Process Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Negative Regulation Of Secretion By Cell Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transport Regulation Of Biological Quality Modulation Of Chemical Synaptic Transmission Postsynaptic Membrane G Protein-coupled Adenosine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Muscle System Process Regulation Of Hormone Secretion Regulation Of Body Fluid Levels Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway GTPase Activity Cellular Response To Catecholamine Stimulus Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Response To Catecholamine G Protein-coupled Serotonin Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Purinergic Nucleotide Receptor Signaling Pathway GTP Binding G Protein-coupled Receptor Activity Regulation Of Insulin Secretion Positive Regulation Of MAPK Cascade Regulation Of Exocytosis Locomotory Behavior Negative Regulation Of Synaptic Transmission Regulation Of Peptide Hormone Secretion Muscle Contraction Negative Regulation Of Insulin Secretion Regulation Of Hormone Levels Negative Regulation Of Peptide Secretion
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