GNAO1 and RGS5

Number of citations of the paper that reports this interaction (PMID 9079700)
22

Data Source:
HPRD (in vitro, in vivo)

		GNAO1	RGS5
Gene Name		guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	regulator of G-protein signaling 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Neuron Projection	Cytoplasm Plasma Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	GTPase Activator Activity
	Biological Process	Muscle Contraction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport	Signal Transduction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		Signaling by GPCR Ca2+ pathway PLC beta mediated events G-protein activation Opioid Signalling Signaling by Wnt G-protein mediated events beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	6 interactors: ADRB2 APP GNAI2 GNAI3 GNAO1 GNAQ
Entrez ID		2775	8490
HPRD ID		00757	04471
Ensembl ID		ENSG00000087258	ENSG00000143248
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	O15539
PDB IDs			2CRP
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Positive Regulation Of ERBB Signaling Pathway Signaling Cell Communication Signal Transduction Cell-cell Signaling Neurological System Process Regulation Of Signal Transduction Locomotory Behavior Positive Regulation Of GTPase Activity Negative Regulation Of Epinephrine Secretion Regulation Of Sensory Perception Of Pain Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Behavior Regulation Of ERBB Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Cellular Response To Stimulus Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Sensory Perception Regulation Of Neurological System Process Regulation Of Adenylate Cyclase Activity Negative Regulation Of Smooth Muscle Contraction Regulation Of Ion Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Cyclase Activity Single-organism Behavior Regulation Of MAP Kinase Activity Negative Regulation Of Secretion By Cell	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Regulation Of Catalytic Activity Regulation Of CAMP Metabolic Process Blood Coagulation Hemostasis G-protein Coupled Receptor Signaling Pathway Neuron Remodeling Regulation Of Body Fluid Levels Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Wound Healing Positive Regulation Of Catalytic Activity Cell Activation Response To Stress Response To Wounding Negative Regulation Of Adenylate Cyclase Activity Regulation Of Protein Kinase Activity Negative Regulation Of Lyase Activity Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of CAMP Biosynthetic Process Neuron Maturation Negative Regulation Of CAMP Metabolic Process Dopamine Receptor Signaling Pathway Negative Regulation Of Nucleotide Metabolic Process Regulation Of Protein Phosphorylation Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Signal Transduction Forebrain Development Regulation Of Phosphorylation Signaling Cell Communication Regulation Of Multicellular Organism Growth Behavior Positive Regulation Of Metabolic Process Regulation Of Ion Transport Cellular Response To Stimulus Synaptic Growth At Neuromuscular Junction Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Protein Binding Cell Maturation Regulation Of Cellular Protein Metabolic Process Brain Development
Tagcloud ?		aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	allergen asm asthma asthmatic attributable bronchial bundles carbachol challenged contractile contraction copious gpcr gpcrs histamine hyperplastic hypertrophic mobilization mucus myocyte nonrespiratory obstruction paradoxically postmortem postreceptor procontractile shortening slices thrombin
Tagcloud (Difference) ?		aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	allergen asm asthma asthmatic attributable bronchial bundles carbachol challenged contractile contraction copious gpcr gpcrs histamine hyperplastic hypertrophic mobilization mucus myocyte nonrespiratory obstruction paradoxically postmortem postreceptor procontractile shortening slices thrombin
Tagcloud (Intersection) ?