GNAO1 and RGS5

Number of citations of the paper that reports this interaction (PubMedID 9079700)
0

Data Source:
HPRD (in vivo, in vitro)

		GNAO1	RGS5
Description		G protein subunit alpha o1	regulator of G protein signaling 5
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GO Annotations	Cellular Component	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Presynaptic Membrane Cell Body Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Adenylate Cyclase Regulator Activity Hydrolase Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	Vesicle Docking Involved In Exocytosis Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Locomotory Behavior Regulation Of Heart Contraction Negative Regulation Of Insulin Secretion Postsynaptic Modulation Of Chemical Synaptic Transmission	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Ca2+ pathway Ca2+ pathway	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cardioembolic stroke (CCSp classification) ( 32047268) Chronotype ( 30696823) Daytime nap ( 33568662) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) HDL cholesterol levels ( 32203549) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)	Height ( 28552196) Hypoalbuminemia ( 34050200) Lead levels in blood ( 25820613) Liver enzyme levels (alanine transaminase) ( 24124411) Motion sickness ( 25628336) Response to mTOR inhibitor (rapamycin) ( 24009623)
Interacting Genes		36 interacting genes: ADORA1 ADRA2A ADRA2C APLP2 CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR ZBTB16	7 interacting genes: ADRB2 APP GNAI2 GNAI3 GNAO1 GNAQ MEOX2
Entrez ID		2775	8490
HPRD ID		00757	04471
Ensembl ID		ENSG00000087258	ENSG00000143248
Uniprot IDs		B3KP89 P09471 Q8N6I9	O15539
PDB IDs		6FUF 6G79 6K41 6OIK 6WWZ 7D76 7D77 7EJ0 7EJ8 7EJA 7EJK 7QVM 7T8X 7T90 7T94 7T96 7W2Z 7W6P 7W7E 7XJJ 7Y24 8DZQ 8E9X 8FN1 8HPT 8HQC 8I95 8I97 8I9L 8I9S 8IA2 8IEC 8IED 8IY9 8IYH 8IYW 8J6D 8JER 8JHN 8JZP 8JZZ 8TZQ 8U02 8XWV 8XX3 8XX6 8XX7 8XXH 8XXR 8XXX 8XXZ 8XYK 8Y0N 8YN7 8YN8 9F33 9F34	2CRP
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G-protein Alpha-subunit Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Plasma Membrane Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway GTPase Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Secretion By Cell Regulation Of Signaling GTPase Activator Activity Negative Regulation Of Secretion Negative Regulation Of Epinephrine Secretion Negative Regulation Of Transport Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion Regulation Of Amine Transport Regulation Of Hormone Secretion G Protein-coupled Peptide Receptor Activity Negative Regulation Of Insulin Secretion Negative Regulation Of Catecholamine Secretion Membrane Regulation Of Secretion By Cell Negative Regulation Of Peptide Secretion Negative Regulation Of Amino Acid Transport GDP-dissociation Inhibitor Activity Regulation Of Secretion G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Protein Transport Negative Regulation Of Establishment Of Protein Localization G Protein-coupled Acetylcholine Receptor Signaling Pathway Alpha2-adrenergic Receptor Activity Response To Alcohol Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Regulation Of Biological Quality Positive Regulation Of GTPase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signaling Positive Regulation Of ERBB Signaling Pathway Dendrite Regulation Of Signal Transduction Cell Communication Regulation Of MAPK Cascade Regulation Of Peptide Hormone Secretion Negative Regulation Of Norepinephrine Secretion	Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Neuronal Dense Core Vesicle Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Cell Body GTPase Activity GTP Binding Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of CAMP/PKA Signal Transduction Modulation Of Chemical Synaptic Transmission Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Superoxide Metabolic Process Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Ion Channel Signaling Pathway Acetylcholine Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Modulation Of Excitatory Postsynaptic Potential Postsynaptic Signal Transduction Cellular Response To Amyloid-beta Ciliary Basal Body Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Amyloid-beta Regulation Of Metal Ion Transport Regulation Of Multicellular Organism Growth Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway G Protein Activity Regulation Of Monoatomic Ion Transport Positive Regulation Of MAPK Cascade Dendrite Positive Regulation Of Macroautophagy Beta2-adrenergic Receptor Activity Acetylcholine Receptor Activator Activity
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