GNAO1 and RGS19

Number of citations of the paper that reports this interaction (PubMedID 8986788)
56

Data Source:
HPRD (in vitro, two hybrid)

		GNAO1	RGS19
Description		G protein subunit alpha o1	regulator of G protein signaling 19
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GO Annotations	Cellular Component	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Presynaptic Membrane Cell Body Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Glutamatergic Synapse GABA-ergic Synapse	Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Adenylate Cyclase Regulator Activity Hydrolase Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	GTPase Activity Protein Binding
	Biological Process	Vesicle Docking Involved In Exocytosis Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Locomotory Behavior Regulation Of Heart Contraction Negative Regulation Of Insulin Secretion Postsynaptic Modulation Of Chemical Synaptic Transmission	Autophagy G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Negative Regulation Of Signal Transduction
Pathways		Ca2+ pathway Ca2+ pathway	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cardioembolic stroke (CCSp classification) ( 32047268) Chronotype ( 30696823) Daytime nap ( 33568662) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) HDL cholesterol levels ( 32203549) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Chronic kidney disease ( 31152163) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Systolic blood pressure ( 30578418)
Interacting Genes		36 interacting genes: ADORA1 ADRA2A ADRA2C APLP2 CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR ZBTB16	26 interacting genes: ALPP CATSPER1 CSNK2A1 CSNK2A2 GDE1 GIPC1 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ HINT1 HOXA1 KRTAP5-6 LCE4A MAPK1 MAPK6 NUFIP2 OPRL1 OSTM1 OTX1 POU4F2 PRKCA PSMA1 TGFBR1 VASN
Entrez ID		2775	10287
HPRD ID		00757	05461
Ensembl ID		ENSG00000087258	ENSG00000171700
Uniprot IDs		B3KP89 P09471 Q8N6I9	B4DP94 P49795
PDB IDs		6FUF 6G79 6K41 6OIK 6WWZ 7D76 7D77 7EJ0 7EJ8 7EJA 7EJK 7QVM 7T8X 7T90 7T94 7T96 7W2Z 7W6P 7W7E 7XJJ 7Y24 8DZQ 8E9X 8FN1 8HPT 8HQC 8I95 8I97 8I9L 8I9S 8IA2 8IEC 8IED 8IY9 8IYH 8IYW 8J6D 8JER 8JHN 8JZP 8JZZ 8TZQ 8U02 8XWV 8XX3 8XX6 8XX7 8XXH 8XXR 8XXX 8XXZ 8XYK 8Y0N 8YN7 8YN8 9F33 9F34	1CMZ
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G-protein Alpha-subunit Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Plasma Membrane Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway GTPase Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Secretion By Cell Regulation Of Signaling GTPase Activator Activity Negative Regulation Of Secretion Negative Regulation Of Epinephrine Secretion Negative Regulation Of Transport Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion Regulation Of Amine Transport Regulation Of Hormone Secretion G Protein-coupled Peptide Receptor Activity Negative Regulation Of Insulin Secretion Negative Regulation Of Catecholamine Secretion Membrane Regulation Of Secretion By Cell Negative Regulation Of Peptide Secretion Negative Regulation Of Amino Acid Transport GDP-dissociation Inhibitor Activity Regulation Of Secretion G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Protein Transport Negative Regulation Of Establishment Of Protein Localization G Protein-coupled Acetylcholine Receptor Signaling Pathway Alpha2-adrenergic Receptor Activity Response To Alcohol Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Regulation Of Biological Quality Positive Regulation Of GTPase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signaling Positive Regulation Of ERBB Signaling Pathway Dendrite Regulation Of Signal Transduction Cell Communication Regulation Of MAPK Cascade Regulation Of Peptide Hormone Secretion Negative Regulation Of Norepinephrine Secretion	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Nucleotide Binding G Protein-coupled Receptor Binding G Protein-coupled Serotonin Receptor Signaling Pathway Protein Kinase CK2 Complex G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Protein Serine/threonine Kinase Activity Negative Regulation Of Insulin Secretion Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Peptide Secretion Negative Regulation Of Secretion By Cell Outer Ear Morphogenesis Protein Kinase Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Ciliary Basal Body Negative Regulation Of Adenylate Cyclase Activity GTPase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Insulin Secretion Negative Regulation Of Secretion Negative Regulation Of Hormone Secretion Protein Serine Kinase Activity GTP Binding Negative Regulation Of Protein Secretion Regulation Of Peptide Hormone Secretion Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Cell Body Kinase Activity MAP Kinase Activity Apoptotic Process Cell Death Signal Transduction Programmed Cell Death Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Transforming Growth Factor Beta Binding Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Hormone Secretion Regulation Of Protein Secretion Plasma Membrane PcG Protein Complex Negative Regulation Of Protein Catabolic Process
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