AREL1 and SEPTIN4

Number of citations of the paper that reports this interaction (PubMedID 23479728)
30

Data Source:
BioGRID (enzymatic study)

		AREL1	SEPTIN4
Description		apoptosis resistant E3 ubiquitin protein ligase 1	septin 4
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cilium Septin Ring Synaptic Vesicle Microtubule Cytoskeleton Transport Vesicle Axon Dendrite Septin Complex Cytoplasmic Vesicle Motile Cilium Cell Division Site Cell Projection Perikaryon Synapse Sperm Annulus Dopaminergic Synapse Presynapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity	Nucleotide Binding Magnesium Ion Binding GTPase Activity Structural Molecule Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Negative Regulation Of Apoptotic Process Regulation Of Inflammatory Response Protein K11-linked Ubiquitination Protein K33-linked Ubiquitination	Neuron Migration Apoptotic Process Spermatogenesis Intracellular Protein Localization Regulation Of Exocytosis Cell Differentiation Flagellated Sperm Motility Positive Regulation Of Protein Ubiquitination Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Spermatid Differentiation Cell Division Hematopoietic Stem Cell Homeostasis Cytoskeleton-dependent Cytokinesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 33627673) Mood instability ( 29187730)
Interacting Genes		10 interacting genes: CRKL DIABLO HTRA2 PIAS4 SEPTIN4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3	10 interacting genes: AREL1 BCL2 PRKN SEPTIN5 SEPTIN8 SNCA SNCAIP SNCB TSC2 XIAP
Entrez ID		9870	5414
HPRD ID		13794	04738
Ensembl ID		ENSG00000119682	ENSG00000108387
Uniprot IDs		A0A7P0T811 O15033	J3KSZ7 O43236
PDB IDs		6JX5 6LOH	6WB3
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Modification By Small Protein Conjugation Regulation Of Protein Targeting To Mitochondrion Post-translational Protein Modification Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process CD40 Receptor Complex Macromolecule Catabolic Process Protein Polyubiquitination Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Proteolysis Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Apoptotic Process Cell Death Negative Regulation Of Cell Communication Regulation Of Protein Localization Programmed Cell Death Negative Regulation Of Signaling Regulation Of Intrinsic Apoptotic Signaling Pathway Cytosol Regulation Of Protein Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Apoptotic Process Protein Modification Process Positive Regulation Of Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Pentacyclic Triterpenoid Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of BMP Signaling Pathway Catabolic Process Ubiquitin Protein Ligase Binding Protein Autoubiquitination Positive Regulation Of Establishment Of Protein Localization Helper T Cell Diapedesis Mitochondrial Intermembrane Space Negative Regulation Of Type 2 Mitophagy Limb Epidermis Development	Phenol-containing Compound Metabolic Process Dopamine Metabolic Process Catecholamine Metabolic Process Biogenic Amine Metabolic Process Amine Metabolic Process Regulation Of Neurotransmitter Secretion Cell Death Positive Regulation Of Protein Linear Polyubiquitination Neuron Apoptotic Process Synaptic Vesicle Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Process Molecular Adaptor Activity Apoptotic Process Negative Regulation Of Programmed Cell Death Programmed Cell Death Dopamine Uptake Involved In Synaptic Transmission Regulation Of Transport Regulation Of Neuron Apoptotic Process Cuprous Ion Binding Protein Polyubiquitination Catecholamine Uptake Dopamine Uptake Septin Ring Septin Complex Negative Regulation Of Autophagy Cell Division Site Synaptic Transmission, Dopaminergic Regulation Of SNARE Complex Assembly Neuronal Cell Body Regulation Of Protein Stability Regulation Of Autophagy Positive Regulation Of Protein Polyubiquitination Regulation Of Apoptotic Process Dopamine Transport Neurotransmitter Reuptake Synaptic Vesicle Membrane Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Metabolic Process Inclusion Body Regulation Of Programmed Cell Death Phospholipase Binding Adult Behavior Regulation Of Dopamine Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Synapse Regulation Of Protein Polyubiquitination Modulation Of Chemical Synaptic Transmission Monoamine Transport Amyloid Fibril Formation
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