AREL1

Description		apoptosis resistant E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Negative Regulation Of Apoptotic Process Regulation Of Inflammatory Response Protein K11-linked Ubiquitination Protein K33-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 33627673) Mood instability ( 29187730)
Novel Interacting Genes		2 novel interacting genes: NPC2 RGS6
Interacting Genes		10 interacting genes: CRKL DIABLO HTRA2 PIAS4 SEPTIN4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3
Entrez ID		9870
HPRD ID		13794
Ensembl ID		ENSG00000119682
Uniprot IDs		A0A7P0T811 O15033
PDB IDs		6JX5 6LOH
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Modification By Small Protein Conjugation Regulation Of Protein Targeting To Mitochondrion Post-translational Protein Modification Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process CD40 Receptor Complex Macromolecule Catabolic Process Protein Polyubiquitination Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Proteolysis Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Apoptotic Process Cell Death Negative Regulation Of Cell Communication Regulation Of Protein Localization Programmed Cell Death Negative Regulation Of Signaling Regulation Of Intrinsic Apoptotic Signaling Pathway Cytosol Regulation Of Protein Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Apoptotic Process Protein Modification Process Positive Regulation Of Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Pentacyclic Triterpenoid Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of BMP Signaling Pathway Catabolic Process Ubiquitin Protein Ligase Binding Protein Autoubiquitination Positive Regulation Of Establishment Of Protein Localization Helper T Cell Diapedesis Mitochondrial Intermembrane Space Negative Regulation Of Type 2 Mitophagy Limb Epidermis Development
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