AREL1 and CRKL

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		AREL1	CRKL
Description		apoptosis resistant E3 ubiquitin protein ligase 1	CRK like proto-oncogene, adaptor protein
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleoplasm Cytoplasm Cytosol Neuromuscular Junction Protein-containing Complex Synapse Extrinsic Component Of Postsynaptic Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity	Phosphotyrosine Residue Binding RNA Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Adaptor Activity Identical Protein Binding Cadherin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Negative Regulation Of Apoptotic Process Regulation Of Inflammatory Response Protein K11-linked Ubiquitination Protein K33-linked Ubiquitination	Regulation Of Cell Growth Blood Vessel Development Urogenital System Development Neuron Migration B Cell Apoptotic Process Regulation Of Leukocyte Migration Outflow Tract Morphogenesis Lipid Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway JNK Cascade Ras Protein Signal Transduction Spermatogenesis Single Fertilization Pattern Specification Process Heart Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Animal Organ Morphogenesis Anterior/posterior Pattern Specification Regulation Of Gene Expression Negative Regulation Of Gene Expression Dendrite Development Cell Migration Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Regulation Of Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Rac Protein Signal Transduction Intracellular Signal Transduction Helper T Cell Diapedesis Reelin-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Retinoic Acid Receptor Signaling Pathway Thymus Development Regulation Of Dendrite Development T Cell Receptor Signaling Pathway Parathyroid Gland Development Cell Chemotaxis Negative Regulation Of SMAD Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Fibroblast Growth Factor Endothelin Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway Postsynaptic Specialization Assembly Cerebellar Neuron Development Cellular Response To Interleukin-7 Chordate Pharynx Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Glial Cell Migration Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cranial Skeletal System Development Regulation Of T Cell Migration
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
Drugs
Diseases
GWAS		General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 33627673) Mood instability ( 29187730)	Mean platelet volume ( 32888494) Platelet distribution width ( 27863252 32888494)
Interacting Genes		10 interacting genes: CRKL DIABLO HTRA2 PIAS4 SEPTIN4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3	78 interacting genes: ABL1 AOX1 AREL1 ARHGAP32 BCAR1 BCR BIK BLK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 DOK2 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM1 GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PSMC6 PTPDC1 PTPN11 PXN RAPGEF1 RPL31 SASH1 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TMEM168 TYK2 USP53 WAC WAS WIPF1 YES1 YY1
Entrez ID		9870	1399
HPRD ID		13794	03596
Ensembl ID		ENSG00000119682	ENSG00000099942
Uniprot IDs		A0A7P0T811 O15033	P46109
PDB IDs		6JX5 6LOH	2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Modification By Small Protein Conjugation Regulation Of Protein Targeting To Mitochondrion Post-translational Protein Modification Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process CD40 Receptor Complex Macromolecule Catabolic Process Protein Polyubiquitination Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Proteolysis Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Apoptotic Process Cell Death Negative Regulation Of Cell Communication Regulation Of Protein Localization Programmed Cell Death Negative Regulation Of Signaling Regulation Of Intrinsic Apoptotic Signaling Pathway Cytosol Regulation Of Protein Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Apoptotic Process Protein Modification Process Positive Regulation Of Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Pentacyclic Triterpenoid Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of BMP Signaling Pathway Catabolic Process Ubiquitin Protein Ligase Binding Protein Autoubiquitination Positive Regulation Of Establishment Of Protein Localization Helper T Cell Diapedesis Mitochondrial Intermembrane Space Negative Regulation Of Type 2 Mitophagy Limb Epidermis Development	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction SH3 Domain Binding Phosphotyrosine Residue Binding Intracellular Signal Transduction Protein Tyrosine Kinase Activity Immune System Process Insulin Receptor Signaling Pathway Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Leukocyte Activation Immune Effector Process ERBB Signaling Pathway B Cell Receptor Signaling Pathway Lymphocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Cytosol Regulation Of Immune System Process B Cell Differentiation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity B Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of MAPK Cascade Cell Migration Cellular Response To Growth Factor Stimulus Plasma Membrane Regulation Of Cell Activation Immune Response-regulating Signaling Pathway Protein Tyrosine Kinase Binding Positive Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Protein Kinase Activity Positive Regulation Of Immune Response Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway T Cell Activation Regulation Of Signaling Regulation Of Cell Communication Response To Growth Factor Regulation Of Multicellular Organismal Development Ephrin Receptor Binding Regulation Of Leukocyte Proliferation
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