AREL1 and DIABLO

Number of citations of the paper that reports this interaction (PMID 23479728)
0

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		AREL1	DIABLO
Gene Name		apoptosis resistant E3 ubiquitin protein ligase 1	diablo, IAP-binding mitochondrial protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Mitochondrion Mitochondrial Intermembrane Space Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Ligase Activity	Protein Binding
	Biological Process	Apoptotic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway
Pathways			Release of apoptotic factors from the mitochondria Apoptotic factor-mediated response SMAC binds to IAPs Programmed Cell Death SMAC-mediated dissociation of IAP:caspase complexes SMAC-mediated apoptotic response Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: DIABLO HTRA2 SEPT4 UBE2D1	20 interactors: AREL1 ARL6IP1 ARNT BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP9 EEF1A1 HTRA2 LTBR MAML2 NGFRAP1 NR4A1 SLC25A47 UBE2K UFM1 XIAP ZNF746
Entrez ID		9870	56616
HPRD ID		13794	05560
Ensembl ID		ENSG00000119682	ENSG00000184047
Uniprot IDs		O15033	K7X1S0 Q502X2 Q9NR28
PDB IDs			1FEW 1G3F 1G73 1TW6 1XB0 1XB1 3D9U 3UIH 3UIJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Pentacyclic Triterpenoid Metabolic Process Positive Regulation Of Endopeptidase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Peptidase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Sperm Mitochondrion Organization Cell Death Death Intrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Oxidative Stress Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Ubiquitination Positive Regulation Of Metabolic Process Protein Processing Regulation Of Apoptotic Process Cellular Response To Stress Positive Regulation Of Catalytic Activity Regulation Of Cell Death Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Response To Herbicide Regulation Of Endopeptidase Activity Mitochondrion Organization Protein Autoprocessing Regulation Of Mitochondrion Degradation Regulation Of Peptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Response To Oxidative Stress Negative Regulation Of Cell Cycle Cellular Response To Interferon-beta Sperm Capacitation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Interferon-beta Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress	Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Regulation Of Cell Death Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Protein Ubiquitination Negative Regulation Of Protein Processing Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Negative Regulation Of Cell Death Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cell Death Apoptotic Signaling Pathway Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Necroptotic Process Positive Regulation Of Signal Transduction Negative Regulation Of Necrotic Cell Death Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Regulation Of Signaling Intracellular Signal Transduction Protein Metabolic Process Regulation Of Neuron Death
Tagcloud ?			angiogen angioprevention argeting attributes b2g2 ccm cdc2 cdc25c cdks conditioned esis gallate grape hallmarks hile howed hpmecs huvecs invasiveness ngioprevention normoxic o2 pc3 phytochemicals procyanidin smac tube vegfr2 warrants
Tagcloud (Difference) ?			angiogen angioprevention argeting attributes b2g2 ccm cdc2 cdc25c cdks conditioned esis gallate grape hallmarks hile howed hpmecs huvecs invasiveness ngioprevention normoxic o2 pc3 phytochemicals procyanidin smac tube vegfr2 warrants
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