GLP1R and GPR37

Number of citations of the paper that reports this interaction (PMID 23864651)
0

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		GLP1R	GPR37
Gene Name		glucagon-like peptide 1 receptor	G protein-coupled receptor 37 (endothelin receptor type B-like)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Ubiquitin Ligase Complex Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Glucagon Receptor Activity	G-protein Coupled Receptor Activity Protein Binding G-protein Coupled Peptide Receptor Activity Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Peptide Binding
	Biological Process	Energy Reserve Metabolic Process Response To Stress G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction CAMP-mediated Signaling Small Molecule Metabolic Process Regulation Of Insulin Secretion Cellular Response To Glucagon Stimulus	G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Locomotion Involved In Locomotory Behavior Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism G alpha (s) signalling events Regulation of insulin secretion Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Glucagon recombinant Exenatide Liraglutide
Diseases
GWAS			Reading and spelling ( 23738518)
Protein-Protein Interactions		41 interactors: ACSF3 APH1A ARFRP1 ATP13A1 C14orf166 C18orf32 CALM1 CAND2 CEND1 CFI CYSTM1 ELOVL1 ERP29 GABBR2 GCG GPR37 GPRASP1 HPN IFITM3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 MFSD5 MRPL22 MYL6 NOTCH2NL NRGN NUCKS1 P4HTM PAQR6 PIGG SLC15A4 STMN1 STMN3 STOML2 SUMO1 SVOP SYNGR3 TMEM147 TSPAN13	8 interactors: ADRB2 GLP1R GRIP1 HSPA1A PARK2 SDCBP STUB1 SYVN1
Entrez ID		2740	2861
HPRD ID		00677	03992
Ensembl ID		ENSG00000112164
Uniprot IDs		P43220	O15354
PDB IDs		3C59 3C5T 3IOL
Enriched GO Terms of Interacting Partners?		Microtubule Depolymerization Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Substantia Nigra Development Microtubule Polymerization Or Depolymerization Cerebellar Granular Layer Maturation Positive Regulation Of Cardiolipin Metabolic Process Protein Unfolding Positive Regulation Of Mitochondrial DNA Replication Stress-induced Mitochondrial Fusion Malonate Catabolic Process Molybdate Ion Transport	Response To Unfolded Protein Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Metabolic Process Cellular Response To Unfolded Protein Regulation Of Signaling Cellular Response To Topologically Incorrect Protein Positive Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Response To Endoplasmic Reticulum Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Stimulus Activation Of Adenylate Cyclase Activity Regulation Of Phosphorus Metabolic Process Protein K63-linked Ubiquitination Regulation Of Signal Transduction Positive Regulation Of Adenylate Cyclase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Signaling Pathway Proteasomal Protein Catabolic Process Regulation Of Binding Protein Autoubiquitination Regulation Of Metabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Lyase Activity Positive Regulation Of Protein Modification Process Negative Regulation Of Protein Binding Regulation Of Adenylate Cyclase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of CAMP Biosynthetic Process Response To Stress Response To Stimulus Regulation Of Cyclase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Communication Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Protein Stabilization Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity
Tagcloud ?		2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable	biosynthetic cd47 cycs dataset dj e2f6 eif2s1 eif2s2 encyclopedia extra fmr1 fxr2 logical mapt nrf1 paelr park2 park6 park7 parkin pen2 perturbation pink1 psenen retrieved seq stringent tomm34 unrecognized
Tagcloud (Difference) ?		2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable	biosynthetic cd47 cycs dataset dj e2f6 eif2s1 eif2s2 encyclopedia extra fmr1 fxr2 logical mapt nrf1 paelr park2 park6 park7 parkin pen2 perturbation pink1 psenen retrieved seq stringent tomm34 unrecognized
Tagcloud (Intersection) ?