GPR37 and GHITM

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		GPR37	GHITM
Description		G protein-coupled receptor 37	growth hormone inducible transmembrane protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Membrane Dendrite Cell Projection Receptor Complex Synapse	Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding	Calcium Channel Activity Protein Binding Calcium:proton Antiporter Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Dendrite Development Locomotion Involved In Locomotory Behavior Cellular Response To Reactive Oxygen Species Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process	Calcium Ion Transport Mitochondrial Calcium Ion Transmembrane Transport Apoptotic Process Inner Mitochondrial Membrane Organization Negative Regulation Of Release Of Cytochrome C From Mitochondria Calcium Export From The Mitochondrion Mitochondrial Potassium Ion Transmembrane Transport Proton Transmembrane Transport Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Cutaneous malignant melanoma ( 26237428 32341527) Nevus count or cutaneous melanoma ( 32341527) Reading and spelling ( 23738518) Refractive error ( 32231278)	Abstraction and mental flexibility ( 31596458) Influenza A (H1N1) infection ( 26379185) Metabolite levels ( 23823483) Mild influenza (H1N1) infection ( 26379185) Refractive error ( 32231278)
Interacting Genes		51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11	13 interacting genes: AGTR1 CCR4 DRD2 FAM209A FXYD3 GPR35 GPR37 HTR2C HTR4 JSRP1 PGRMC2 SLC22A1 TMEM242
Entrez ID		2861	27069
HPRD ID		03992	17038
Ensembl ID		ENSG00000170775	ENSG00000165678
Uniprot IDs		O15354	Q9H3K2
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway COPII-coated ER To Golgi Transport Vesicle Regulation Of Catecholamine Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dendrite ERAD Pathway Synaptic Transmission, Dopaminergic Regulation Of Autophagy Of Mitochondrion Cell Communication Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Chemical Synaptic Transmission Regulation Of Membrane Potential Regulation Of Dopamine Secretion Cell-cell Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signal Transduction Trans-synaptic Signaling Signaling Regulation Of Amine Transport Synaptic Signaling Modulation Of Chemical Synaptic Transmission Neuron-glial Cell Signaling Response To Psychosocial Stress Cellular Localization Synapse Positive Regulation Of Autophagy Of Mitochondrion Golgi Membrane Negative Regulation Of Dopamine Secretion Transmembrane Transport Response To Endoplasmic Reticulum Stress G Protein-coupled Receptor Binding Cellular Response To Topologically Incorrect Protein Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Glucose-6-phosphate Transport Volume-sensitive Chloride Channel Activity Establishment Of Localization In Cell Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Neurotransmitter Uptake Volume-sensitive Anion Channel Activity Regulation Of Synaptic Transmission, GABAergic Intracellular Transport Plasma Membrane Calcium Ion Transmembrane Import Into Cytosol Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Mitochondrial Fusion	G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Renal Sodium Excretion Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Catecholamine Uptake Dopamine Uptake Serotonin Binding Serotonin Receptor Signaling Pathway Serotonin Receptor Activity Monoatomic Cation Transport G Protein-coupled Serotonin Receptor Activity Interneuron Migration Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Calcium Ion Transmembrane Import Into Cytosol Set1C/COMPASS Complex Neurotransmitter Receptor Activity Dopamine Transport Neurotransmitter Reuptake Monoatomic Ion Transport G Protein-coupled Serotonin Receptor Signaling Pathway Chemokine Receptor Activity Metal Ion Transport Regulation Of Appetite Regulation Of Sequestering Of Calcium Ion Monoamine Transport Neurotransmitter Uptake Dopamine Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Angiotensin Type I Receptor Activity Calcium Ion Transmembrane Transport Catecholamine Metabolic Process Large Intestinal Transit Dendrite Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Intracellular Signaling Cassette Bradykinin Receptor Binding G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Calcium Ion Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Prosaposin Receptor Activity 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding (R)-carnitine Transmembrane Transport Pyrimidine Nucleoside Transmembrane Transporter Activity (R)-carnitine Transmembrane Transporter Activity
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