GLP1R and CLPS

Number of citations of the paper that reports this interaction (PubMedID 26272612)
67

Data Source:
BioGRID (protein complementation assay)

		GLP1R	CLPS
Description		glucagon like peptide 1 receptor	colipase
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Glucagon Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Signaling Receptor Activity Glucagon-like Peptide 1 Receptor Activity	Enzyme Activator Activity Lipase Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction Post-translational Protein Targeting To Membrane, Translocation Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Hormone Secretion Regulation Of Biological Quality Cellular Response To Glucagon Stimulus Response To Psychosocial Stress	Retinoid Metabolic Process Lipid Metabolic Process Digestion Response To Bacterium Lipid Catabolic Process Response To Food
Pathways		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events Glucagon-type ligand receptors	Digestion of dietary lipid Retinoid metabolism and transport
Drugs		Glucagon Exenatide Liraglutide Albiglutide Dulaglutide Lixisenatide Semaglutide Taspoglutide Tirzepatide Efpeglenatide Glutazumab	B-nonylglucoside (Hydroxyethyloxy)Tri(Ethyloxy)Octane METHOXYUNDECYLPHOSPHINIC ACID
Diseases
GWAS		Blood sugar levels ( 29403010) Fasting blood glucose ( 25631608) Fasting blood glucose adjusted for BMI ( 25625282) Fasting glucose ( 34059833) Type 2 diabetes ( 32499647)	Blood protein levels ( 30072576)
Interacting Genes		112 interacting genes: ACSF3 AGXT AIG1 APH1A ARFRP1 ARLN ASGR2 ATP13A1 ATP5MC3 ATP6AP2 C18orf32 CALM1 CAND2 CAV1 CCDC167 CD63 CD81 CELA3B CEND1 CFI CLDN7 CLIP4 CLPS CNIH4 COMT CYSRT1 CYSTM1 DAD1 DHRS7 EBP ELOVL1 EMC7 EMP2 ERP29 FGL1 FTL GABBR2 GCG GJB1 GNAS GP2 GPR108 GPR37 GPRASP1 GRINA HAMP HPN IER3 IFITM3 KHK KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP5-9 LAPTM4A LINC00269 MRPL22 MT-ATP6 MT-ND4L MTCH2 MYL6 NBPF19 NOTCH2NLA NRGN NUCKS1 OCIAD2 OST4 P4HTM PAM PAQR6 PGRMC1 PIGG POMT2 PPIB PRSS2 PSMD8 RAB5B RAB5C RNF5 RTN3 RTN4 RTRAF SAA1 SCGB2A1 SEC11C SELENOK SERPINA1 SLC15A4 SLC37A4 SLC61A1 SLC9D1 SPTSSA STMN1 STMN3 STOML2 SVOP SYNGR3 SYNGR4 SYS1 TM4SF4 TMBIM6 TMEM147 TMEM176B TOMM6 TSPAN13 UGT1A9 VAPB ZNF99	4 interacting genes: GLP1R LIPF PNLIP PNLIPRP2
Entrez ID		2740	1208
HPRD ID		00677	00356
Ensembl ID		ENSG00000112164	ENSG00000137392
Uniprot IDs		A0A142FHB8 P43220	A0A087WZW1 A0A087X0Q7 P04118
PDB IDs		3C59 3C5T 3IOL 4ZGM 5E94 5NX2 5OTT 5OTU 5OTV 5OTW 5OTX 5VEW 5VEX 6B3J 6GB1 6ORV 6VCB 6X18 6X19 6X1A 6XOX 7C2E 7DUQ 7DUR 7E14 7EVM 7FIM 7KI0 7KI1 7LCI 7LCJ 7LCK 7LLL 7LLY 7RG9 7RGP 7RTB 7S15 7S1M 7S3I 7VBH 7VBI 7X8R 7X8S 8JIP 8JIR 8JIS 8WG7 8YW3 9IVG 9IVM 9J1P
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Intermediate Filament Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Keratin Filament Neutrophil Migration Host-mediated Activation Of Viral Process Endoplasmic Reticulum Membrane Organization Chemical Homeostasis Intracellular Chemical Homeostasis Synaptic Vesicle Membrane Intracellular Calcium Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Granulocyte Migration	Triacylglycerol Lipase Activity Lipase Activity Carboxylic Ester Hydrolase Activity Triglyceride Metabolic Process Acylglycerol Metabolic Process Neutral Lipid Metabolic Process Lipoprotein Lipase Activity Triglyceride Catabolic Process Phospholipase A1 Activity High-density Lipoprotein Particle Remodeling Acylglycerol Catabolic Process Lipid Catabolic Process Glycerolipid Metabolic Process Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Sterol Homeostasis Cholesterol Homeostasis Glucagon-like Peptide 1 Receptor Activity Positive Regulation Of Triglyceride Lipase Activity Galactolipase Activity Fatty Acid Biosynthetic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Galactolipid Catabolic Process Lipid Homeostasis Glucagon Receptor Activity All-trans-retinyl-palmitate Hydrolase, All-trans-retinol Forming Activity Malate Dehydrogenase Activity Lipid Metabolic Process Lipid Digestion Response To Psychosocial Stress Carboxylic Acid Biosynthetic Process Retinyl-palmitate Esterase Activity Post-translational Protein Targeting To Membrane, Translocation Fatty Acid Metabolic Process Positive Regulation Of Lipase Activity Malate Metabolic Process Positive Regulation Of Catalytic Activity Small Molecule Metabolic Process Intestinal Cholesterol Absorption Cellular Response To Glucagon Stimulus Monoacylglycerol Lipase Activity Phosphatidylcholine Catabolic Process Activation Of Adenylate Cyclase Activity Intestinal Lipid Absorption Hydrolase Activity Small Molecule Biosynthetic Process Zymogen Granule Membrane Positive Regulation Of Adenylate Cyclase Activity Monocarboxylic Acid Metabolic Process
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