GPR37 and TTYH2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		GPR37	TTYH2
Description		G protein-coupled receptor 37	tweety family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Membrane Dendrite Cell Projection Receptor Complex Synapse	Plasma Membrane Membrane Chloride Channel Complex
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding	Volume-sensitive Anion Channel Activity Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Calcium Ion Binding Protein Binding Metal Ion Binding Volume-sensitive Chloride Channel Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Dendrite Development Locomotion Involved In Locomotory Behavior Cellular Response To Reactive Oxygen Species Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process	Monoatomic Ion Transport Chloride Transport L-glutamate Transmembrane Transport Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Stimuli-sensing channels
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Cutaneous malignant melanoma ( 26237428 32341527) Nevus count or cutaneous melanoma ( 32341527) Reading and spelling ( 23738518) Refractive error ( 32231278)	Systolic blood pressure (cigarette smoking interaction) ( 26752167)
Interacting Genes		51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11	15 interacting genes: CCND2 CDKN2B COPB1 ERBB2 FGFR4 GPR37 GRM1 IGF1R IKBKG KAT2A KDELR2 NEDD4 NF2 PDGFRA TRARG1
Entrez ID		2861	94015
HPRD ID		03992	16394
Ensembl ID		ENSG00000170775	ENSG00000141540
Uniprot IDs		O15354	B4DKD1 Q9BSA4
PDB IDs			7P54 7P5M
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway COPII-coated ER To Golgi Transport Vesicle Regulation Of Catecholamine Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dendrite ERAD Pathway Synaptic Transmission, Dopaminergic Regulation Of Autophagy Of Mitochondrion Cell Communication Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Chemical Synaptic Transmission Regulation Of Membrane Potential Regulation Of Dopamine Secretion Cell-cell Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signal Transduction Trans-synaptic Signaling Signaling Regulation Of Amine Transport Synaptic Signaling Modulation Of Chemical Synaptic Transmission Neuron-glial Cell Signaling Response To Psychosocial Stress Cellular Localization Synapse Positive Regulation Of Autophagy Of Mitochondrion Golgi Membrane Negative Regulation Of Dopamine Secretion Transmembrane Transport Response To Endoplasmic Reticulum Stress G Protein-coupled Receptor Binding Cellular Response To Topologically Incorrect Protein Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Glucose-6-phosphate Transport Volume-sensitive Chloride Channel Activity Establishment Of Localization In Cell Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Neurotransmitter Uptake Volume-sensitive Anion Channel Activity Regulation Of Synaptic Transmission, GABAergic Intracellular Transport Plasma Membrane Calcium Ion Transmembrane Import Into Cytosol Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Mitochondrial Fusion	Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Receptor Complex Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Tyrosine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction COPI-coated Vesicle Membrane Transport Vesicle Ubiquitin Ligase Complex Protein Autophosphorylation Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Regulation Of Cell Population Proliferation Phosphorylation Long-term Memory Neuromuscular Junction Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Signal Transduction Protein Kinase Activity Peptidyl-lysine Glutarylation Histone Glutaryltransferase Activity Histone Succinyltransferase Activity Peptide Glutaryltransferase Activity G Protein-coupled Receptor Homodimeric Complex G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Formation Of Structure Involved In A Symbiotic Process Platelet-derived Growth Factor Alpha-receptor Activity Plasma Membrane Protein Modification Process ERBB3:ERBB2 Complex Kinase Activity Histone H3K9 Acetyltransferase Activity Prosaposin Receptor Activity Dendriole Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Dimeric Complex Channel Inhibitor Activity Odontogenesis Of Dentin-containing Tooth Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
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