GPR37 and SLC8A2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		GPR37	SLC8A2
Description		G protein-coupled receptor 37	solute carrier family 8 member A2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Membrane Dendrite Cell Projection Receptor Complex Synapse	Plasma Membrane Postsynaptic Density Membrane Basolateral Plasma Membrane Axon Dendrite Sarcolemma Cell Projection Neuronal Cell Body Dendritic Spine Perikaryon Axon Terminus Synapse Presynapse Postsynapse
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding	Calcium:sodium Antiporter Activity Calmodulin Binding Sodium Ion Transmembrane Transporter Activity Calcium Ion Transmembrane Transporter Activity Antiporter Activity Metal Ion Binding Calcium:monoatomic Cation Antiporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Dendrite Development Locomotion Involved In Locomotory Behavior Cellular Response To Reactive Oxygen Species Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process	Response To Ischemia Monoatomic Ion Transport Sodium Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Cell Communication Learning Or Memory Learning Memory Regulation Of Gene Expression Sodium Ion Transmembrane Transport Regulation Of Short-term Neuronal Synaptic Plasticity Synapse Organization Cognition Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Long-term Synaptic Potentiation Neuron Cellular Homeostasis Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Modulation Of Excitatory Postsynaptic Potential Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Action Potential Firing Pattern Regulation Of Calcineurin-mediated Signaling Transport Across Blood-brain Barrier Positive Regulation Of Intracellular Signal Transduction Regulation Of Cardiac Conduction Calcium Ion Export Across Plasma Membrane
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Cutaneous malignant melanoma ( 26237428 32341527) Nevus count or cutaneous melanoma ( 32341527) Reading and spelling ( 23738518) Refractive error ( 32231278)	Resting-state electroencephalogram vigilance ( 29703947)
Interacting Genes		51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11	7 interacting genes: GPR35 GPR37 PPP3CB YWHAB YWHAE YWHAQ YWHAZ
Entrez ID		2861	6543
HPRD ID		03992	15990
Ensembl ID		ENSG00000170775	ENSG00000118160
Uniprot IDs		O15354	Q9UPR5
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway COPII-coated ER To Golgi Transport Vesicle Regulation Of Catecholamine Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dendrite ERAD Pathway Synaptic Transmission, Dopaminergic Regulation Of Autophagy Of Mitochondrion Cell Communication Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Chemical Synaptic Transmission Regulation Of Membrane Potential Regulation Of Dopamine Secretion Cell-cell Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signal Transduction Trans-synaptic Signaling Signaling Regulation Of Amine Transport Synaptic Signaling Modulation Of Chemical Synaptic Transmission Neuron-glial Cell Signaling Response To Psychosocial Stress Cellular Localization Synapse Positive Regulation Of Autophagy Of Mitochondrion Golgi Membrane Negative Regulation Of Dopamine Secretion Transmembrane Transport Response To Endoplasmic Reticulum Stress G Protein-coupled Receptor Binding Cellular Response To Topologically Incorrect Protein Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Glucose-6-phosphate Transport Volume-sensitive Chloride Channel Activity Establishment Of Localization In Cell Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Neurotransmitter Uptake Volume-sensitive Anion Channel Activity Regulation Of Synaptic Transmission, GABAergic Intracellular Transport Plasma Membrane Calcium Ion Transmembrane Import Into Cytosol Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Mitochondrial Fusion	Phosphoserine Residue Binding Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Negative Regulation Of Transport Negative Regulation Of Calcium Ion Transmembrane Transport Protein Sequestering Activity Negative Regulation Of Protein Localization To Nucleus Protein Targeting Negative Regulation Of Calcium Ion Transport Protein Domain Specific Binding Negative Regulation Of Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Locomotion Involved In Locomotory Behavior Melanosome Regulation Of Monoatomic Ion Transport Focal Adhesion Regulation Of Lysosome Organization Antibacterial Innate Immune Response Transmembrane Transporter Binding Regulation Of Calcium Ion Transmembrane Transport Regulation Of Protein Localization To Nucleus Signal Transduction Negative Regulation Of Protein Localization Regulation Of Calcium Ion Transport Phosphoprotein Binding Regulation Of Transport Regulation Of Monoatomic Cation Transmembrane Transport Protein Phosphatase Inhibitor Activity Substantia Nigra Development Ubiquitin Protein Ligase Binding Intracellular Signaling Cassette Cadherin Binding Regulation Of Protein Localization Regulation Of Metal Ion Transport Lysosome Organization Regulation Of Vacuole Organization Neural Nucleus Development Enzyme Binding Regulation Of Protein Transport Regulation Of Innate Immune Response Protein Phosphatase Binding Negative Regulation Of Innate Immune Response Prosaposin Receptor Activity Regulation Of Heart Rate By Hormone Synaptic Target Recognition Regulation Of Cellular Localization Establishment Of Protein Localization Regulation Of Establishment Of Protein Localization Negative Regulation Of Immune System Process
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