GPR37 and ZDHHC11

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		GPR37	ZDHHC11
Description		G protein-coupled receptor 37	zDHHC palmitoyltransferase 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Membrane Dendrite Cell Projection Receptor Complex Synapse	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Endosome Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Signaling Adaptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Dendrite Development Locomotion Involved In Locomotory Behavior Cellular Response To Reactive Oxygen Species Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process	Positive Regulation Of Defense Response To Virus By Host Protein Targeting To Membrane Peptidyl-L-cysteine S-palmitoylation Antiviral Innate Immune Response
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Maturation of spike protein
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Cutaneous malignant melanoma ( 26237428 32341527) Nevus count or cutaneous melanoma ( 32341527) Reading and spelling ( 23738518) Refractive error ( 32231278)	Lung cancer in ever smokers ( 28604730) Pancreatic cancer ( 25086665) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11	4 interacting genes: CREB3 GPR37 TMEM14B TRAF6
Entrez ID		2861	79844
HPRD ID		03992	15708
Ensembl ID		ENSG00000170775	ENSG00000188818
Uniprot IDs		O15354	Q9H8X9
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway COPII-coated ER To Golgi Transport Vesicle Regulation Of Catecholamine Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dendrite ERAD Pathway Synaptic Transmission, Dopaminergic Regulation Of Autophagy Of Mitochondrion Cell Communication Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Chemical Synaptic Transmission Regulation Of Membrane Potential Regulation Of Dopamine Secretion Cell-cell Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signal Transduction Trans-synaptic Signaling Signaling Regulation Of Amine Transport Synaptic Signaling Modulation Of Chemical Synaptic Transmission Neuron-glial Cell Signaling Response To Psychosocial Stress Cellular Localization Synapse Positive Regulation Of Autophagy Of Mitochondrion Golgi Membrane Negative Regulation Of Dopamine Secretion Transmembrane Transport Response To Endoplasmic Reticulum Stress G Protein-coupled Receptor Binding Cellular Response To Topologically Incorrect Protein Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Glucose-6-phosphate Transport Volume-sensitive Chloride Channel Activity Establishment Of Localization In Cell Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Neurotransmitter Uptake Volume-sensitive Anion Channel Activity Regulation Of Synaptic Transmission, GABAergic Intracellular Transport Plasma Membrane Calcium Ion Transmembrane Import Into Cytosol Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Mitochondrial Fusion	Regulation Of Dopamine Metabolic Process Prosaposin Receptor Activity Neuropeptide Binding Locomotion Catecholamine Biosynthetic Process Peptide Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Stress Neuropeptide Receptor Activity Dopamine Biosynthetic Process Locomotion Involved In Locomotory Behavior Bone Resorption DNA-templated Transcription Positive Regulation Of T Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Ubiquitin-ubiquitin Ligase Activity CD40 Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Receptor Localization To Synapse Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Catalytic Activity Bone Remodeling Myeloid Dendritic Cell Differentiation Interleukin-1-mediated Signaling Pathway Positive Regulation Of Osteoclast Differentiation CD40 Receptor Complex Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Protein Localization To Synapse Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Endolysosomal Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Interleukin-17A-mediated Signaling Pathway Protein Branched Polyubiquitination Protein Kinase B Binding Interleukin-33-mediated Signaling Pathway Myeloid Dendritic Cell Activation Toll-like Receptor 3 Signaling Pathway Cellular Response To Lectin Regulation Of Lipopolysaccharide-mediated Signaling Pathway T-helper 1 Type Immune Response Fc-epsilon Receptor Signaling Pathway Interleukin-17-mediated Signaling Pathway Identical Protein Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Monocyte Chemotaxis
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