GPR37 and GPR17

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		GPR37	GPR17
Description		G protein-coupled receptor 37	G protein-coupled receptor 17
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Membrane Dendrite Cell Projection Receptor Complex Synapse	Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Receptor Serine/threonine Kinase Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Dendrite Development Locomotion Involved In Locomotory Behavior Cellular Response To Reactive Oxygen Species Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Signal Transduction G Protein-coupled Receptor Signaling Pathway Oligodendrocyte Differentiation Chemokine-mediated Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Leukotriene receptors G alpha (q) signalling events P2Y receptors G alpha (i) signalling events
Drugs			Uridine diphosphate glucose Uridine-5'-Diphosphate Galactose-uridine-5'-diphosphate
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Cutaneous malignant melanoma ( 26237428 32341527) Nevus count or cutaneous melanoma ( 32341527) Reading and spelling ( 23738518) Refractive error ( 32231278)	Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11	2 interacting genes: GNA13 GPR37
Entrez ID		2861	2840
HPRD ID		03992	04351
Ensembl ID		ENSG00000170775	ENSG00000144230
Uniprot IDs		O15354	G4XH68 Q13304
PDB IDs			7Y89
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway COPII-coated ER To Golgi Transport Vesicle Regulation Of Catecholamine Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dendrite ERAD Pathway Synaptic Transmission, Dopaminergic Regulation Of Autophagy Of Mitochondrion Cell Communication Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Chemical Synaptic Transmission Regulation Of Membrane Potential Regulation Of Dopamine Secretion Cell-cell Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signal Transduction Trans-synaptic Signaling Signaling Regulation Of Amine Transport Synaptic Signaling Modulation Of Chemical Synaptic Transmission Neuron-glial Cell Signaling Response To Psychosocial Stress Cellular Localization Synapse Positive Regulation Of Autophagy Of Mitochondrion Golgi Membrane Negative Regulation Of Dopamine Secretion Transmembrane Transport Response To Endoplasmic Reticulum Stress G Protein-coupled Receptor Binding Cellular Response To Topologically Incorrect Protein Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Glucose-6-phosphate Transport Volume-sensitive Chloride Channel Activity Establishment Of Localization In Cell Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Neurotransmitter Uptake Volume-sensitive Anion Channel Activity Regulation Of Synaptic Transmission, GABAergic Intracellular Transport Plasma Membrane Calcium Ion Transmembrane Import Into Cytosol Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Mitochondrial Fusion	Negative Regulation Of Nitric-oxide Synthase Activity Alpha-galactosidase Activity Prosaposin Receptor Activity D5 Dopamine Receptor Binding Glycosylceramide Catabolic Process Regulation Of Nitric-oxide Synthase Activity Glycoside Catabolic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Dopamine Metabolic Process Locomotion Involved In Locomotory Behavior Rho-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Oxidoreductase Activity Dopamine Biosynthetic Process Glycosylceramide Metabolic Process Glycosphingolipid Catabolic Process Glycolipid Catabolic Process Ceramide Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Oxidoreductase Activity Regulation Of Dopamine Metabolic Process Catecholamine Biosynthetic Process Neuropeptide Receptor Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Neuropeptide Binding Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Peptide Binding G Protein-coupled Receptor Signaling Pathway Amine Biosynthetic Process Biogenic Amine Biosynthetic Process Dopamine Metabolic Process Branching Involved In Blood Vessel Morphogenesis Heterotrimeric G-protein Complex Sphingolipid Catabolic Process G Protein-coupled Peptide Receptor Activity Membrane Lipid Catabolic Process Dendrite Development Catecholamine Metabolic Process Regulation Of Fibroblast Migration Regulation Of Postsynapse Assembly Hsp70 Protein Binding Glycosphingolipid Metabolic Process Brush Border Membrane Oligosaccharide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Biogenic Amine Metabolic Process Heat Shock Protein Binding Rho Protein Signal Transduction Platelet Activation
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