GLP1R and ATP6AP2

Number of citations of the paper that reports this interaction (PubMedID 26272612)
67

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		GLP1R	ATP6AP2
Description		glucagon like peptide 1 receptor	ATPase H+ transporting accessory protein 2
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Autophagosome Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane Vacuolar Proton-transporting V-type ATPase Complex Axon Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Dendritic Spine Membrane Proton-transporting V-type ATPase Complex Cell Projection Synapse Postsynaptic Membrane Extracellular Exosome Tertiary Granule Membrane Bounding Membrane Of Organelle Ficolin-1-rich Granule Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Glucagon Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Signaling Receptor Activity Glucagon-like Peptide 1 Receptor Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction Post-translational Protein Targeting To Membrane, Translocation Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Hormone Secretion Regulation Of Biological Quality Cellular Response To Glucagon Stimulus Response To Psychosocial Stress	Angiotensin Maturation Vacuolar Acidification Lysosomal Lumen Acidification Central Nervous System Maturation Rostrocaudal Neural Tube Patterning Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta1 Production Regulation Of MAPK Cascade Eye Pigmentation Endosomal Lumen Acidification Intracellular PH Reduction Head Morphogenesis Golgi Lumen Acidification Positive Regulation Of Canonical Wnt Signaling Pathway Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events Glucagon-type ligand receptors	Metabolism of Angiotensinogen to Angiotensins Neutrophil degranulation
Drugs		Glucagon Exenatide Liraglutide Albiglutide Dulaglutide Lixisenatide Semaglutide Taspoglutide Tirzepatide Efpeglenatide Glutazumab
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Blood sugar levels ( 29403010) Fasting blood glucose ( 25631608) Fasting blood glucose adjusted for BMI ( 25625282) Fasting glucose ( 34059833) Type 2 diabetes ( 32499647)	Metabolite levels ( 23823483)
Interacting Genes		112 interacting genes: ACSF3 AGXT AIG1 APH1A ARFRP1 ARLN ASGR2 ATP13A1 ATP5MC3 ATP6AP2 C18orf32 CALM1 CAND2 CAV1 CCDC167 CD63 CD81 CELA3B CEND1 CFI CLDN7 CLIP4 CLPS CNIH4 COMT CYSRT1 CYSTM1 DAD1 DHRS7 EBP ELOVL1 EMC7 EMP2 ERP29 FGL1 FTL GABBR2 GCG GJB1 GNAS GP2 GPR108 GPR37 GPRASP1 GRINA HAMP HPN IER3 IFITM3 KHK KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP5-9 LAPTM4A LINC00269 MRPL22 MT-ATP6 MT-ND4L MTCH2 MYL6 NBPF19 NOTCH2NLA NRGN NUCKS1 OCIAD2 OST4 P4HTM PAM PAQR6 PGRMC1 PIGG POMT2 PPIB PRSS2 PSMD8 RAB5B RAB5C RNF5 RTN3 RTN4 RTRAF SAA1 SCGB2A1 SEC11C SELENOK SERPINA1 SLC15A4 SLC37A4 SLC61A1 SLC9D1 SPTSSA STMN1 STMN3 STOML2 SVOP SYNGR3 SYNGR4 SYS1 TM4SF4 TMBIM6 TMEM147 TMEM176B TOMM6 TSPAN13 UGT1A9 VAPB ZNF99	20 interacting genes: ADRA1A AGT CD72 CREB3 GLP1R HTR2C NINJ1 NKG7 NSG1 PMP22 PTTG1IP REN SEC22A TIMMDC1 TMEM203 TMEM97 UPK2 VAMP5 VKORC1 ZBTB16
Entrez ID		2740	10159
HPRD ID		00677	06454
Ensembl ID		ENSG00000112164	ENSG00000182220
Uniprot IDs		A0A142FHB8 P43220	O75787
PDB IDs		3C59 3C5T 3IOL 4ZGM 5E94 5NX2 5OTT 5OTU 5OTV 5OTW 5OTX 5VEW 5VEX 6B3J 6GB1 6ORV 6VCB 6X18 6X19 6X1A 6XOX 7C2E 7DUQ 7DUR 7E14 7EVM 7FIM 7KI0 7KI1 7LCI 7LCJ 7LCK 7LLL 7LLY 7RG9 7RGP 7RTB 7S15 7S1M 7S3I 7VBH 7VBI 7X8R 7X8S 8JIP 8JIR 8JIS 8WG7 8YW3 9IVG 9IVM 9J1P	3LBS 3LC8 6WLW 6WM2 6WM3 6WM4 7U4T
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Intermediate Filament Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Keratin Filament Neutrophil Migration Host-mediated Activation Of Viral Process Endoplasmic Reticulum Membrane Organization Chemical Homeostasis Intracellular Chemical Homeostasis Synaptic Vesicle Membrane Intracellular Calcium Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Granulocyte Migration	Type 2 Angiotensin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Membrane Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Blood Volume By Renin-angiotensin Establishment Of Protein Localization To Plasma Membrane Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Mesonephros Development Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Protein Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Hormone Levels Cell-cell Signaling Blood Vessel Diameter Maintenance Vasoconstriction Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Cell Communication Regulation Of Tube Size Regulation Of System Process Signaling CGMP-mediated Signaling Kidney Development Regulation Of Lipid Transport Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Golgi To Plasma Membrane Protein Transport Vesicle-mediated Transport To The Plasma Membrane Intracellular Protein Localization Establishment Of Protein Localization Glucagon-like Peptide 1 Receptor Activity Regulation Of Monocyte Chemotaxis Ferroptosis Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Deacetylase Activity Postsynaptic Neurotransmitter Receptor Cycle Neurotransmitter Receptor Cycle Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Positive Regulation Of Inflammatory Response Animal Organ Development Regulation Of Systemic Arterial Blood Pressure Signaling Receptor Binding Protein Localization To Plasma Membrane Regulation Of Heart Contraction Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Phospholipase C-activating Adrenergic Receptor Signaling Pathway Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
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